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  • Author: Wilmar M. Wiersinga x
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Wilmar M. Wiersinga
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Article Type:
Editorial
DOI:
https://doi.org/10.1159/000359914
Volume/Issue:
Volume 3: Issue 1
Free access
Wilmar M. Wiersinga
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Article Type:
Editorial
DOI:
https://doi.org/10.1159/000377722
Volume/Issue:
Volume 4: Issue 1
Free access
Wilmar M. Wiersinga Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Article Type:
Editorial
DOI:
https://doi.org/10.1159/000438909
Volume/Issue:
Volume 4: Issue 3
Free access
Wilmar M. Wiersinga
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Article Type:
Editorial
DOI:
https://doi.org/10.1159/000348243
Volume/Issue:
Volume 2: Issue 1
Free access
Wilmar M. Wiersinga
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Article Type:
Editorial
DOI:
https://doi.org/10.1159/000457813
Volume/Issue:
Volume 6: Issue 1
Open access
Wilmar M. Wiersinga
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Article Type:
Editorial
DOI:
https://doi.org/10.1159/000444424
Volume/Issue:
Volume 5: Issue 1
Open access
Luigi Bartalena Department of Medicine and Surgery, University of Insubria, Varese, Italy

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Wilmar M. Wiersinga Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Standardization of treatment outcomes in randomized clinical trials (RCTs) for active, moderate-to-severe Graves’ orbitopathy (GO) is needed to make results of different RCTs comparable and to draw sound conclusions on the efficacy of a given treatment. Both subjective patient-reported outcome (PRO) and objective clinician-reported outcome (CRO) are important in this regard. In this paper, it is proposed that primary PRO should be the evaluation of treatment-related changes in the quality of life by the use of a validated and disease-specific questionnaire (GO-QoL). The proposed primary CRO is a revised composite index, which includes only objective items and provides an overall assessment of the effects of treatment. Secondary outcomes should also be provided in RCTs to show the effects of treatment on individual features of GO, as well on persistence of activity (by the 7-item Clinical Activity Score), safety, relapses of GO, need for subsequent medical and/or surgical treatments, and other indicators (orbital volume, cytokines, TSH receptor antibody levels). Assessment of the overall response to treatment by primary and secondary outcomes should be made 3 months after treatment completion.

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000510700
Volume/Issue:
Volume 9: Issue 1_Suppl
Free access
Wilmar M. Wiersinga
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Simon H. Pearce
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Article Type:
Editorial
DOI:
https://doi.org/10.1159/000501853
Volume/Issue:
Volume 8: Issue 4
Free access
Simon H. Pearce
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Wilmar M. Wiersinga
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Article Type:
Other
DOI:
https://doi.org/10.1159/000520114
Volume/Issue:
Volume 10: Issue 6
Free access
Wilmar M. Wiersinga Institutes of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck

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Theo J. Visser Institutes of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck

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Article Type:
Editorial
DOI:
https://doi.org/10.1159/000337020
Volume/Issue:
Volume 1: Issue 1
Free access