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Saleha Babli Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada
Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia

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Richard J.  Payne Department of Otolaryngology, Royal Victoria Hospital, McGill University, Montreal, Québec, Canada

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Elliot Mitmaker Department of Surgery, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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Juan Rivera Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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Patients Total thyroidectomy was performed in all patients with malignancy or suspicious for malignancy confirmed by preoperative fine-needle aspiration biopsy. Patients in whom the initial surgical procedure was lobectomy underwent completion

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Helmi Khadra Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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Ahmed Deniwar Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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Khuzema Mohsin Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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Dominique Monlezun Tulane University School of Medicine, New Orleans, Louisiana, USA

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Emad Kandil Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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benign nodules, which can be managed conservatively. Suspicious US features described to select nodules with malignancy potential to undergo fine needle aspiration (FNA) included hypoechogenicity, microcalcifications, irregular margins, non

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Vittoria Guarda Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany

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Anja Pickhard Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany

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Melanie Boxberg Institute of Pathology, Technical University of Munich, Munich, Germany

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Katja Specht Institute of Pathology, Technical University of Munich, Munich, Germany

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Anna Maria Stefanie Buchberger Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany

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performed in 4 cases (30.77%), with consistent findings of a cold area with no iodine uptake. A CT scan was obtained in 9 cases (69.23%), and MRI in just 1 case (7.69%). As an initial diagnostic test, 7 patients underwent fine needle aspiration cytology

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Omar Abdul Hameed Ali Department of Surgery, University Charity and Teaching Hospital and Khartoum Breast Care Center

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Abdul Fatah Abdul Gadir Department of Pathology, University of Medical Sciences and Technology, Khartoum, Sudan

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nodular – regardless of their volumes – or to show the mildest degrees of enlargement as compared to reference volumes were considered to have bilateral disease. For more accurate assessment of the contralateral lobe, intraoperative fine-needle aspiration

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Mario Monaco Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale', IRCCS, Italy

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Gennaro Chiappetta Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale', IRCCS, Italy

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Concetta Aiello Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale', IRCCS, Italy

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Antonella Federico Istituto per l'Endocrinologia e l'Oncologia Sperimentale (IEOS), Consiglio Nazionale delle Ricerche (CNR), c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), Università degli Studi di Napoli ‘Federico II', Naples, Italy

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Romina Sepe Istituto per l'Endocrinologia e l'Oncologia Sperimentale (IEOS), Consiglio Nazionale delle Ricerche (CNR), c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), Università degli Studi di Napoli ‘Federico II', Naples, Italy

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Daniela Russo Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale', IRCCS, Italy

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Alfredo Fusco Istituto per l'Endocrinologia e l'Oncologia Sperimentale (IEOS), Consiglio Nazionale delle Ricerche (CNR), c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), Università degli Studi di Napoli ‘Federico II', Naples, Italy
Instituto Nacional de Câncer - INCA, Rio de Janeiro, Brazil

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Pierlorenzo Pallante Istituto per l'Endocrinologia e l'Oncologia Sperimentale (IEOS), Consiglio Nazionale delle Ricerche (CNR), c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), Università degli Studi di Napoli ‘Federico II', Naples, Italy

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carcinoma, oxyphilic type. Distinguishing a benign neoplasm from a malignant neoplasm based on cytologic analysis of fine-needle aspiration biopsy is not possible. Features such as pleomorphism, anaplasia, hyperchromatism, and atypia are also observed in

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Rima Bėrontienė Clinics of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Edita Jašinskienė Clinics of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Rosita Kiudelienė Clinics of Pediatrics, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Gintaras Kuprionis Clinics of Radiology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Jurgita Makštienė Clinics of Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Raminta Macaitytė Clinics of Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Dalia Marčiulionytė Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Lina Poškienė Clinics of Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Agnė Šemetaitė Clinics of Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Vygantas Šidlauskas Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Raimondas Valickas Clinics of Radiology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Rimantas Žalinkevičius Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Rasa Verkauskienė Clinics of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania
Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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left lobe (47.37%), p = 0.73]. Nodule microcalcification was seen in 14 cases (24.56%), irregular margins in 47 cases (82.46%), active blood flow in 38 cases (66.67%), and reactive regional lymph nodes in 4 cases (7.02%). Fine-Needle Aspiration

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Kaoru Kobayashi Kuma Hospital, Kobe, Japan

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Hisashi Ota Kuma Hospital, Kobe, Japan

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Mitsuyoshi Hirokawa Kuma Hospital, Kobe, Japan

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Tomonori Yabuta Kuma Hospital, Kobe, Japan

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Mitsuhiro Fukushima Kuma Hospital, Kobe, Japan

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Hiroo Masuoka Kuma Hospital, Kobe, Japan

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Takuya Higashiyama Kuma Hospital, Kobe, Japan

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Minoru Kihara Kuma Hospital, Kobe, Japan

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Yasuhiro Ito Kuma Hospital, Kobe, Japan

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Akihiro Miya Kuma Hospital, Kobe, Japan

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Akira Miyauchi Kuma Hospital, Kobe, Japan

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existed within each nodule separately or individually on Doppler ultrasonography (Fig. 1 a). Fine-needle aspiration cytology revealed a “follicular neoplasm.” A right lobectomy of the thyroid was performed, and the whole nodule was diagnosed as a

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Yulia P. Sych Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation

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Valentin V. Fadeev Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation

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Elena P. Fisenko Laboratory of Ultrasound Diagnostics, Federal State Research Institution “B.V. Petrovsky National Research Centre of Surgery”, Moscow, Russian Federation

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Marina Kalashnikova Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation

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images in B-mode and Doppler regimen were recorded and stored at first visualization before the application of fine-needle aspiration biopsy (FNAB) using different ultrasound machines: Aixplorer (France), Voluson E8 (GE, USA), Hitachi (Japan), or Aloka

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Luigino Dal Maso Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Daniela Pierannunzio National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy

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Silvia Francisci National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy

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Angela De Paoli Epidemiological Department, Azienda Zero, Padova, Italy

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Federica Toffolutti Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Salvatore Vaccarella Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France

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Silvia Franceschi Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Ugo Fedeli Epidemiological Department, Azienda Zero, Padova, Italy

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of the DEPTH Working Group
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of the DEPTH Working Group

diagnostic pressure, namely fine-needle aspiration biopsies of thyroid nodules, were reported at the population level in some Italian areas after 2014 ( 24 ). Meanwhile, the growth in thyroid cancer surgery previously registered in Italy leveled off after

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Massimiliano Andrioli Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano

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Chiara Carzaniga Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano

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Luca Persani Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano
Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy

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performing and not directly performing thyroid US in immediately and better identifying the nodules (those classified as borderline, suspicious of malignancy or malignant) worthy of further investigations (i.e. fine-needle aspiration and cytology), and

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