Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
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Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
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Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
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Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
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the R75G TSHB variant cannot be distinguished from patients with subclinical hyperthyroidism, defined biochemically as having normal serum free thyroxine (T4) and triiodothyronine (T3) concentrations in the presence of a subnormal serum level of TSH
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Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
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Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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residues 234–264, 316–347, and 426–454 of thyroid hormone receptor beta. Spurious hyperthyroxinemia due to thyroid function assay interferences is a frequent pitfall in the differential diagnosis of central hyperthyroidism. Novel Insights
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
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Amsterdam Public Health, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands
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symptoms can be subtle and also for monitoring therapy in hypo- or hyperthyroidism and assessing suppressive therapy in patients with thyroid cancer. Unfortunately, TSH assays are poorly standardized to date. The IFCC Working Group on Standardization of
University of Lille, Lille, France
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University of Lille, Lille, France
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Department of Dermatology, Lille University Hospital, Lille, France
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University of Lille, Lille, France
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-old male who was incidentally found to have mild hyperthyroidism with low TSH (0.043 mU/L (0.4–3.6)) and slightly increased free thyroxine (FT4) (14.6 pmol/L (8.4–14.4)) ( Fig. 1 ). Free triiodothyronine (FT3) was not measured. The patient had received an
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Department of Pediatrics, Turku University Hospital, Turku, Finland
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Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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Introduction Nonautoimmune hyperthyroidism (NAH) is caused by a constitutively activating thyroid stimulating hormone receptor (TSHR) germline mutation. Germline mutations in TSHR lead to sporadic and familial NAH (SNAH, FNAH) whereas somatic
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Response options GD patients with mild active TED and a CAS of three points present a management challenge. Do you have a preference regarding first-line treatment for hyperthyroidism? Anti-thyroid drugs, radioiodine, radioiodine plus oral
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Introduction The thioamide compounds 6- n -propyl-2-thiouracil (PTU), methimazole (MMI) and carbimazole represent widely used anti-thyroid therapeutic drugs in the treatment of hyperthyroidism [ 1 ]. Their main pharmacological target is the
Department of Internal Medicine, University of Genoa, Genoa, Italy
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Department of Internal Medicine, University of Genoa, Genoa, Italy
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Department of Internal Medicine, University of Genoa, Genoa, Italy
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measured by means of the Italian version of ThyPRO. This questionnaire consists of 85 questions, grouped into 13 multi-item scales. The ThyPRO scales concern the following aspects: goiter symptoms, hyperthyroid symptoms, hypothyroid symptoms, eye symptoms
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Introduction Graves’ disease (GD) is the most common cause of hyperthyroidism in both adults and children [ 1 ]. For patients with hyperthyroidism due to GD, there are 3 well-known and effective treatment options: antithyroid drugs (ATDs
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Introduction Amiodarone-induced thyroid dysfunction, either hypothyroidism (AIH) or hyperthyroidism – thyrotoxicosis (AIT), affects up to 20% of amiodarone-treated patients [ 1 ]. Two types of AIT exist and they are characterized by distinct