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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
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Department of Gynaecology and Obstetrics, Aalborg University Hospital, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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biochemical evaluation with the measurement of thyroid-stimulating hormone (TSH). Results revealed an elevated plasma level of TSH (>100 mIU/L). Simultaneous measurements of total thyroxine (T4) as well as total triiodothyronine (T3) showed that the plasma
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
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Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
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Kristensen SR Bülow Pedersen I Vestergaard P . Pregnancy week-specific reference ranges for thyrotropin and free thyroxine in the North Denmark region pregnancy cohort . Thyroid 2019 29 430 – 438 . ( https://doi.org/10.1089/thy.2018.0628 ) 15
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DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
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Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany
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Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Reagents Nonradioactive 3,3’-diiodothyronine (3,3’-T2), 3,3’,5’-triiodothyronine (rT3), 3,3’,5-triiodothyronine (T3) and thyroxine (T4) were purchased from Sigma-Aldrich (Zwijndrecht, the Netherlands). [ 125 I]-3,3’-T2, [ 125 I]-rT3, [ 125 I]-T3, [ 125 I
Department of Internal Medicine (I), Osaka Medical College, Takatsuki City
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laboratory tests showing high values of free thyroxine (FT 4 ) and free tri-iodothyronine (FT 3 ), low levels of thyrotropin-stimulating hormone (TSH), increased TSH receptor antibody (TRAb) titer and/or thyroid-associated ophthalmopathy. PT was diagnosed by
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Medical Education Center, Hamamatsu University School of Medicine, Shizuoka, Japan
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Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan
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of 0.01 mIU/L (reference range: 0.05–5.00), a free thyroxine level of 23.2 pmol/L (reference range: 11.6–21.9), and a free tri-iodothyronine level of 6.6 pmol/L (reference range: 3.5–6.2) as measured by ECLusys (Roche Diagnostics K.K., Tokyo, Japan
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, Prange AJ Jr: Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N Engl J Med 1999;340:424–429. 3 Saravanan P, Chau WF, Roberts N, Vedhara K, Greenwood R, Dayan CM: Psychological well-being in
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useful background and guidance, we suggest that the approach recommended there carries potential risks, with the likely outcome of an increase in the proportion of ‘younger' elderly patients treated for SCH and the withholding of thyroxine treatment in
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statistically significant (p = 0.81). For both subgroups (high TSH and low FT4) the power was >90%. (3) We mentioned the possibility that thyroxine therapy was started too late in pregnancy, but a trend analysis on starting thyroxine treatment from 8 to 15
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Objectives: When exposed to iodine contrast medium (ICM), thyroid dysfunction may develop, due to excess amounts of iodide. The incidence of contrast-induced thyroid dysfunction has been difficult to interpret, because of the observational and retrospective designs of most previous studies. With the Swedish CArdioPulmonary bioImage Study (SCAPIS), where randomly selected individuals aged 50–65 years, underwent contrast-enhanced coronary CT angiography (CCTA), we were able to prospectively assess the incidence, magnitude and clinical impact of contrast-induced thyroid dysfunction.
Methods: In 422 individuals, thyroid hormone levels were analysed before and 4–12 weeks after CCTA. Thyroid-related patient-reported outcome questionnaires (ThyPRO) at the time of pre and post CCTA blood samplings were provided by 368 of those individuals. Thyroid peroxidase antibodies (TPOab) were analysed and ultrasound of the thyroid gland was performed to detect any thyroid nodules.
Results: There was a small statistically significant effect on thyroid hormone levels but no cases of overt hypo- or hyperthyroidism after ICM. Subclinical hypo- or hyperthyroidism or isolated low/high levels of free thyroxine (fT4) developed in 3.5% of the population with normal hormone levels pre-CCTA, but without any increased thyroid-related symptoms compared to the remaining cohort. Elevated TPOab and being born outside Sweden were risk factors of developing subclinical hypothyroidism. Presence of thyroid nodules was not associated with ICM-induced thyroid dysfunction.
Conclusion: The results of this prospective study support the notion that in iodine-sufficient countries, ICM associated thyroid dysfunction is rare, usually mild, self-limiting and oligo/asymptomatic in subjects aged 50–65 years.
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Department of Pathology, Albert Einstein School of Medicine, New York, N.Y., USA
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HA, Ronin C, Rottmann M, Thijssen JH, Toussaint B; International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), Scientific Division Working Group for Standardization of Thyroid Function Tests (WG-STFT): Measurement of free thyroxine