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Rachelle P Mendoza Department of Pathology, University of Rochester Medical Center, Rochester, New York, USA

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Richard Cody Simon Department of Pathology, University of Chicago, Chicago, Illinois, USA

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Nicole A Cipriani Department of Pathology, University of Chicago, Chicago, Illinois, USA

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Tatjana Antic Department of Pathology, University of Chicago, Chicago, Illinois, USA

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-up information of these nodules. The incidence rate of a nonbenign final diagnosis in these nodules with single FNA was 0% ( Table 2 ). Figure 1 Diagram of the subsequent fine needle aspiration cytology and resection diagnosis of benign thyroid nodules

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Ziyu Wan Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

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Ying Li Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Xiaoqian Dong Xiangya School of Nursing, Central South University, Changsha, Hunan, China

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Yue Kang Xiangya School of Nursing, Central South University, Changsha, Hunan, China

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Juan Luo Xiangya School of Nursing, Central South University, Changsha, Hunan, China

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Jiangang Wang Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Pingting Yang Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Yaqin Wang Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Yinglong Duan Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

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Jianfei Xie Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

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Andy S K Cheng Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong, China

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). However, the incidence of TNs is reported to be between 10.2% and 38.4% ( 2 , 3 , 4 , 5 ), and up to 7.9% of these nodules are malignant ( 6 ). Recent advancements in ultrasonographic techniques have enabled the early detection of TNs ( 7 ), thereby

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George J. Kahaly Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Luigi Bartalena Department of Medicine and Surgery, University of Insubria, Varese, Italy

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Lazlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Laurence Leenhardt Thyroid and Endocrine Tumors Unit, Pitié Salpêtrière Hospital, Sorbonne University, Paris, France

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Kris Poppe Endocrine Unit, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Simon H. Pearce Department of Endocrinology, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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cases per 100,000 individuals [ 6 ]. GD occurs more often in women and has a population prevalence of 1–1.5%. Approximately 3% of women and 0.5% of men develop GD during their lifetime [ 7 ]. The peak incidence of GD occurs among patients aged 30

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Roberto Negro Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy

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Pierpaolo Trimboli Clinic for Nuclear Medicine and Competence Center for Thyroid Diseases, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland

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uncertainties regarding nodule recurrence than certainties. Available data show a 5-year cumulative incidence of regrowth of 28%, and a 5-year cumulative incidence of retreatment of 10% [ 13 ]. On the one hand, we can state that TA is “cost- and risk

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Rosa M. García-Moreno Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain

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Cristina Escabias Nuclear Medicine Department, Hospital Universitario La Paz, Madrid, Spain

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Cristina Utrilla Radiology Department, Hospital Universitario La Paz, Madrid, Spain

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Elena Ruiz-Bravo Pathology Department, Hospital Universitario La Paz, Madrid, Spain

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Margarita Sánchez Ophthalmology Department, Hospital Universitario La Paz, Madrid, Spain

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Beatriz Lecumberri Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain

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incidental radioiodine uptake in the orbital region. Introduction Differentiated thyroid cancer is one of the most prevalent solid tumor types with a rising incidence, and papillary thyroid carcinoma (PTC) represents the most frequent variant [ 1

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Alessandro Brancatella Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Nicola Viola Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Sandra Brogioni Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Lucia Montanelli Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Chiara Sardella Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Paolo Vitti Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Claudio Marcocci Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Isabella Lupi Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Francesco Latrofa Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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reported as a common adverse effect during ICPi treatment [ 1 ]. A similar overall incidence of hypothyroidism (7–10%) has been estimated for the three types of drugs. At variance, the incidence of thyrotoxicosis differs according to the ICPi regimen, being

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Martina Tavarelli Unité Thyroïde Tumeurs Endocrines, Paris, France

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Julie Sarfati Unité Thyroïde Tumeurs Endocrines, Paris, France

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Christian De Gennes Service de Médecine Interne Immuno-clinique, Paris, France

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Julien Haroche Service de Médecine Interne 2, Paris, France

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Camille Buffet Unité Thyroïde Tumeurs Endocrines, Paris, France

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Cécile Ghander Unité Thyroïde Tumeurs Endocrines, Paris, France

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Jean Marc Simon Service de Radiothérapie, Paris, France

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Fabrice Ménégaux Service de Chirurgie Générale et Digestive, Groupe Hospitalier et Faculté de Médecine Pitié-Salpêtrière, Institut du Cancer, Université Pierre et Marie Curie, Paris, France

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Laurence Leenhardt Unité Thyroïde Tumeurs Endocrines, Paris, France

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, the incidence of paraneoplastic syndromes will most likely increase. Acknowledgments We thank L. Chami and V. Magnano San Lio for the help in the interpretation of radiological images. Disclosure Statement All authors declare they have

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Peter Taylor Departments of Diabetes and Endocrinology, Royal United Hospital, Bath
Centre for Endocrine and Diabetes Sciences, Department of Medicine, Cardiff University School of Medicine, Cardiff, UK

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Sandip Bhatt Departments of Gastroenterology, Royal United Hospital, Bath

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Ravi Gouni Departments of Diabetes and Endocrinology, Royal United Hospital, Bath

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Jonathan Quinlan Departments of Gastroenterology, Royal United Hospital, Bath

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Tony Robinson Departments of Diabetes and Endocrinology, Royal United Hospital, Bath

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fetal loss [ 4 , 6 ]. • Anti-thyroid drugs are the mainstay of treatment throughout pregnancy [ 7 , 8 ]. • Propylthiouracil (PTU) is generally used first line in pregnancy following an increased incidence of scalp defects such as aplasia cutis [ 9

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Ayanthi Wijewardene Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Matti Gild Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Carolina Nylén Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Geoffrey Schembri Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Paul Roach Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Jeremy Hoang Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Ahmad Aniss Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Anthony Glover Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Mark Sywak Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Stan Sidhu Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Diana Learoyd Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Bruce Robinson Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Lyndal Tacon Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Roderick Clifton-Bligh Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Introduction The incidence of thyroid cancer is increasing worldwide [ 1 ]. In Australia, thyroid cancer is increasing more than any other malignancy, with incidence rising from 2.7 to 13 per 100,000 persons between 1982 and 2019 [ 2 , 3

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Niko W. de Jong Dutch Association of Graves’ Patients

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G.M. Baljet Royal Dutch Pharmacists Association (KNMP), Amersfoort, The Netherlands

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population is changing with a strong increase of the ageing population. As the incidence of Hashimoto’s hypothyroidism increases with advancing age, a greying population will increase the use of thyroid hormones. Nevertheless, this cannot be the whole

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