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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Radiology and Nuclear Medicine, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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characteristic by the NCCN. No reports of more aggressive behavior of DTC, defined as increased risk for metastasized disease at diagnosis, recurrence, or increased morbidity or mortality when compared to children with sporadic DTC, could be found. The one
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, Kingston A , Collerton J , et al. Serum thyroid function, mortality and disability in advanced old age: the Newcastle 85+ study . J Clin Endocrinol Metab . 2016 Nov ; 101 ( 11 ): 4385 – 94 . 10.1210/jc.2016-1935 27552542 0021-972X 7
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cardiovascular morbidity (arrhythmia, cardiomyopathy, stroke) and mortality, particularly in the elderly. Likewise, hyperthyroidism is an established risk factor for osteoporosis in postmenopausal women. These epidemiological findings have recently led to a
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Heart Center Bad Neustadt, Clinic for Interventional Electrophysiology, Bad Neustadt an der Saale, Germany
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nonthyroidal illness syndrome (NTIS), euthyroid sick syndrome or TACITUS (thyroid allostasis in critical illness, tumors, uremia and starvation) and is accompanied by increased mortality and morbidity [ 3 , 4 ]. Several trials have demonstrated improved
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weight are important predictors of neonatal mortality and morbidity [ 3 ], and it has been proposed that some of the complications associated with maternal thyroid disease may be secondary to preterm birth [ 4 ]. Evidence suggests an increased risk of
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Italy
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IL6 and CRP ( 12 , 31 ), or to higher rates of mortality or increased length of hospitalisation for Covid-19 disease ( 32 , 33 , 34 ). Possible reasons for such discrepancies are the small-scale nature of these patient cohorts and the fact that our
Department of Surgery, Ito Hospital, Shibuya-ku, Tokyo, Japan
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). Regardless, caution should be exercised in regard to FTC-related mortality and recurrence among patients with large tumors. Although it is more difficult to assess margins in FTC with larger tumors, the extent of invasion should also be assessed
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a codon 634 mutation, the development of MTC can occur long before the recommended age for prophylactic thyroidectomy (5 years). To prevent such cancers and the related morbidity and mortality, it is likely that the current guidelines should be
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/TNM [ 11 ], none of these features would have an impact on disease-related mortality and only the presence of LN metastases would change stage I to II exclusively in patients older than 55 years. On the other hand, the importance currently given to these
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-related mortality, including age >45 years, male sex, carcinoma size >2 cm 3 , invasion into surrounding tissue, histological subtype, and distant metastasis. It spreads mostly by lymphatic channels and metastasis to lymph nodes is frequent; however, this does not