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L.A. Jonker Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

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C.A. Lebbink Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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M.C.J. Jongmans Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

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R.A.J. Nievelstein Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Pediatric Radiology and Nuclear Medicine, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

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J.H.M. Merks Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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E.J.M. Nieveen van Dijkum Department of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands

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T.P. Links Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands

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N. Hoogerbrugge Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands

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A.S.P. van Trotsenburg Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands

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H.M. van Santen Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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characteristic by the NCCN. No reports of more aggressive behavior of DTC, defined as increased risk for metastasized disease at diagnosis, recurrence, or increased morbidity or mortality when compared to children with sporadic DTC, could be found. The one

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Salman Razvi Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Bronia Arnott Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Dawn Teare Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Shaun Hiu Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Nicki O’Brien Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom

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Simon H. Pearce Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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, Kingston A , Collerton J , et al. Serum thyroid function, mortality and disability in advanced old age: the Newcastle 85+ study . J Clin Endocrinol Metab . 2016 Nov ; 101 ( 11 ): 4385 – 94 . 10.1210/jc.2016-1935 27552542 0021-972X 7

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Dagmar Führer Department of Endocrinology and Metabolism, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Klaudia Brix Department of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany

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Heike Biebermann Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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cardiovascular morbidity (arrhythmia, cardiomyopathy, stroke) and mortality, particularly in the elderly. Likewise, hyperthyroidism is an established risk factor for osteoporosis in postmenopausal women. These epidemiological findings have recently led to a

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Johannes W. Dietrich Department of Endocrinology and Diabetes, Medical Hospital I, Germany

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Patrick Müller Department of Cardiology and Angiology, Medical Hospital II, Germany
Heart Center Bad Neustadt, Clinic for Interventional Electrophysiology, Bad Neustadt an der Saale, Germany

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Fabian Schiedat Department of Cardiology and Angiology, Medical Hospital II, Germany

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Markus Schlömicher Department of Cardiac Surgery, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, Germany

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Justus Strauch Department of Cardiac Surgery, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, Germany

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Apostolos Chatzitomaris Department of Endocrinology and Diabetes, Medical Hospital I, Germany

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Harald H. Klein Department of Endocrinology and Diabetes, Medical Hospital I, Germany

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Andreas Mügge Department of Cardiology and Angiology, Medical Hospital II, Germany

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Eddy Rijntjes Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Ina Lehmphul Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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nonthyroidal illness syndrome (NTIS), euthyroid sick syndrome or TACITUS (thyroid allostasis in critical illness, tumors, uremia and starvation) and is accompanied by increased mortality and morbidity [ 3 , 4 ]. Several trials have demonstrated improved

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Stine Linding Andersen Department of Endocrinology, Aalborg University Hospital, Aalborg

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Jørn Olsen Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark

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Chun Sen Wu Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark

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Peter Laurberg Department of Endocrinology, Aalborg University Hospital, Aalborg

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weight are important predictors of neonatal mortality and morbidity [ 3 ], and it has been proposed that some of the complications associated with maternal thyroid disease may be secondary to preterm birth [ 4 ]. Evidence suggests an increased risk of

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Ilaria Muller Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Anita Daturi Department of Clinical Sciences and Community Health, University of Milan, Italy

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Matteo Varallo Department of Clinical Sciences and Community Health, University of Milan, Italy

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Tiziana E Re Internal Medicine - High Intensity of Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Davide Dazzi Casa di Cura Val Parma SRL, Langhirano (Parmigiano: Langhiràn), Italy

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Sara Maioli Department of Clinical Sciences and Community Health, University of Milan, Italy

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Erica Crivicich Department of Clinical Sciences and Community Health, University of Milan, Italy

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Francesco Di Marco Department of Clinical Sciences and Community Health, University of Milan, Italy

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Virgilio Longari Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Beatrice Dazzi Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Massimo Castellani Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Giovanna Mantovani Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Maura Arosio Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Mario Salvi Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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IL6 and CRP ( 12 , 31 ), or to higher rates of mortality or increased length of hospitalisation for Covid-19 disease ( 32 , 33 , 34 ). Possible reasons for such discrepancies are the small-scale nature of these patient cohorts and the fact that our

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Haruhiko Yamazaki Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama City, Kanagawa, Japan
Department of Surgery, Ito Hospital, Shibuya-ku, Tokyo, Japan

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Kiminori Sugino Department of Surgery, Ito Hospital, Shibuya-ku, Tokyo, Japan

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Ryohei Katoh Department of Pathology, Ito Hospital, Shibuya-ku, Tokyo, Japan

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Kenichi Matsuzu Department of Surgery, Ito Hospital, Shibuya-ku, Tokyo, Japan

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Wataru Kitagawa Department of Surgery, Ito Hospital, Shibuya-ku, Tokyo, Japan

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Mitsuji Nagahama Department of Surgery, Ito Hospital, Shibuya-ku, Tokyo, Japan

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Aya Saito Department of Surgery, Yokohama City University School of Medicine, Yokohama City, Kanagawa, Japan

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Koichi Ito Department of Surgery, Ito Hospital, Shibuya-ku, Tokyo, Japan

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). Regardless, caution should be exercised in regard to FTC-related mortality and recurrence among patients with large tumors. Although it is more difficult to assess margins in FTC with larger tumors, the extent of invasion should also be assessed

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Abbas Al-Kurd Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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David J. Gross Neuroendocrine Tumor Unit, Department of Endocrinology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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David Zangen Department of Pediatrics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Karine Atlan Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Haggi Mazeh Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Unit, Department of Endocrinology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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a codon 634 mutation, the development of MTC can occur long before the recommended age for prophylactic thyroidectomy (5 years). To prevent such cancers and the related morbidity and mortality, it is likely that the current guidelines should be

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Pedro Weslley Souza Rosario Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Gabriela Franco Mourão Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Pedro Henrique Lopes Oliveira Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Tulio Henrique Silva Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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/TNM [ 11 ], none of these features would have an impact on disease-related mortality and only the presence of LN metastases would change stage I to II exclusively in patients older than 55 years. On the other hand, the importance currently given to these

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Anne-Sophie Bertrand Department of Interventional Radiology Imaging, Antoine Lacassagne Cancer Research Center, Nice, France

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Antoine Iannessi Department of Interventional Radiology Imaging, Antoine Lacassagne Cancer Research Center, Nice, France

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Isabelle Peyrottes Department of Anatomopathology, Antoine Lacassagne Cancer Research Center, Nice, France

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Alexis Lacout Department of Radiology, Centre médico-chirurgical ELSAN, Aurillac, France

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Antoine Thyss Department of Oncology, Antoine Lacassagne Cancer Research Center, Nice, France

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Pierre-Yves Marcy Department of Interventional Radiology and Diagnostic Imaging, Polyclinique Les Fleurs Groupe ELSAN, Ollioules, France

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-related mortality, including age >45 years, male sex, carcinoma size >2 cm 3 , invasion into surrounding tissue, histological subtype, and distant metastasis. It spreads mostly by lymphatic channels and metastasis to lymph nodes is frequent; however, this does not

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