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María de los Ángeles Garayalde Gamboa Service of Endocrinology, Metabolism, Nutrition, and Diabetes, Buenos Aires British Hospital, Buenos Aires, Argentina

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Melina Saban Service of Endocrinology, Metabolism, Nutrition, and Diabetes, Buenos Aires British Hospital, Buenos Aires, Argentina

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Marina Ines Curriá Service of Endocrinology, Metabolism, Nutrition, and Diabetes, Buenos Aires British Hospital, Buenos Aires, Argentina

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with 30 mCi of iodine 131 and oral LT4. During the following 3 years he had an excellent response receiving oral LT4 150 μg/day (2.14 μg/kg/day). In November 2017, he was hospitalized for intestinal sub­occlusion and secondary malabsorptive syndrome

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000503324
Volume/Issue:
Volume 8: Issue 6
Free access
George J. Kahaly Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Luigi Bartalena Department of Medicine and Surgery, University of Insubria, Varese, Italy

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Lazlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Laurence Leenhardt Thyroid and Endocrine Tumors Unit, Pitié Salpêtrière Hospital, Sorbonne University, Paris, France

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Kris Poppe Endocrine Unit, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Simon H. Pearce Department of Endocrinology, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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hyperthyroidism is 1.2–1.6, 0.5–0.6 overt and 0.7–1.0% subclinical [ 1 , 5 ]. The most frequent causes are Graves’ disease (GD) and toxic nodular goiter. GD is the most prevalent cause of hyperthyroidism in iodine-replete geographical areas, with 20–30 annual

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000490384
Volume/Issue:
Volume 7: Issue 4
Free access
Pedro Weslley Rosario Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Gabriela Franco Mourão Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Maria Regina Calsolari Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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radioactive iodine (RAI), US should be obtained a few months later in all patients as part of the investigation that defines the response to therapy [ 1 - 3 ]. After this first assessment, the American Thyroid Association (ATA) [ 2 ] and the European Thyroid

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000493978
Volume/Issue:
Volume 8: Issue 1
Free access
Alice Nervo Oncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, Italy

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Alberto Ragni Oncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, Italy

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Alessandro Piovesan Oncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, Italy

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Valentina Marica Oncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, Italy

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Enrica Migliore Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, Italy

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Marco Gallo Oncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, Italy

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Emanuela Arvat Oncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza Hospital, Turin, Italy

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Introduction Treatment with lenvatinib (LEN), a multitarget tyrosine kinase inhibitor (TKI), has shown great efficacy in patients with advanced radioactive iodine-refractory (RAI-R) thyroid cancer (TC), both in clinical trials and in a real

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000508186
Volume/Issue:
Volume 10: Issue 1
Free access
Enrico Papini Department of Endocrinology and Metabolism, Regina Apostolorum Hospital, Rome, Italy

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Hervé Monpeyssen Thyroid Unit, American Hospital, Paris, France

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Andrea Frasoldati Department of Endocrinology and Metabolism, Arcispedale Santa Maria Nuova IRCCS-ASL, Reggio Emilia, Italy

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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vast majority of the thyroid nodule population but are not intended for pediatric cases. While TA is covered, in extenso, EA and radioactive iodine ablation procedures for thyroid nodules are only mentioned in passing. How the diagnosis of a benign

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000508484
Volume/Issue:
Volume 9: Issue 4
Free access
Markus Eszlinger Departments of Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany

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Paul Stewardson Department of Medical Science and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada

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John B McIntyre Precision Oncology Hub Laboratory, Alberta Health Services, Tom Baker Cancer Centre, Calgary, Alberta, Canada

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Adrian Box Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Moosa Khalil Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Martin Hyrcza Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Konstantin Koro Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Dean Ruether Section of Medical Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Jiahui Wu Department of Medical Science and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada

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Ralf Paschke Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada

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were found in 12.6% of patients and RET gene fusions in 14.3% ( 13 ). The prevalence of fusions increases for metastatic/advanced patients’ WT of other aberrations. In radioactive iodine (RAI)-resistant metastatic thyroid cancers without BRAF

Article Type:
Research Article
Collections:
Thyroid cancer - basic and translational
DOI:
https://doi.org/10.1530/ETJ-21-0061
Volume/Issue:
Volume 11: Issue 1
Open access
Andrew G Gianoukakis The Lundquist Institute at Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, California, USA

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Jennifer H Choe Department of Medicine, Duke University Medical Center/Duke Cancer Institute, Durham, North Carolina, USA

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Daniel W Bowles Division of Medical Oncology, University of Colorado, Aurora, Colorado, USA

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Marcia S Brose Department of Otorhinolaryngology: Head and Neck Surgery, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Lori J Wirth Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

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Taofeek Owonikoko Winship Cancer Institute of Emory University, Atlanta, Georgia, USA

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Svetlana Babajanyan Bayer HealthCare Pharmaceuticals, Whippany, New Jersey, USA

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Francis P Worden Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA

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Introduction Differentiated thyroid cancer (DTC) accounts for nearly 90% of all thyroid cancer cases ( 1 ). The standard initial treatment is surgery followed by radioactive iodine (RAI) or observation; however, approximately 5–15% of patients

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-23-0039
Volume/Issue:
Volume 13: Issue 1
Open access
Yasuhiro Ito Department of Surgery, Kuma Hospital, Shimoyamate-dori, Chuo-ku, Kobe, Hyogo, Japan

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Akira Miyauchi Department of Surgery, Kuma Hospital, Shimoyamate-dori, Chuo-ku, Kobe, Hyogo, Japan

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-, and post-operative findings. They are useful in deciding therapeutic strategies, including the extent of surgery, adjuvant therapies such as radioactive iodine (RAI) administration, and postoperative follow-up imaging studies. Based on the 8th Edition

Article Type:
Review Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-24-0196
Volume/Issue:
Volume 13: Issue 5
Open access
Clotilde Saïe Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Cécile Ghander Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Samir Saheb Apheresis Unit, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France

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Christel Jublanc Department of Endocrinology, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Denis Lemesle Department of Anaesthesia, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Charlotte Lussey-Lepoutre Nuclear Medicine Department, Pitié-Salpêtrière Hospital APHP, Sorbonne Université, Inserm U970, Paris, France

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Laurence Leenhardt Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Fabrice Menegaux Department of Surgery, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Christophe Tresallet Department of Surgery, Avicennes Hospital, Paris, France

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Camille Buffet Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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thyrotoxicosis). In the patients with GD, the median TSH receptor antibody level was 16 U/L (range 9–41 U/L). All patients with AIT had type 2 AIT, confirmed by 123 -iodine thyroid scintigraphy (online suppl. Fig.; www.karger.com/doi/10.1159/000507019) or

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000507019
Volume/Issue:
Volume 10: Issue 1
Free access
Kerstin Krause Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Juliane Weiner Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Sebastian Hönes Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Nora Klöting Division of Endocrinology and Nephrology, Department of Medicine, Germany
IFB Adiposity Diseases, Leipzig University Medical Centre, Leipzig, Germany

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Eddy Rijntjes Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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John T. Heiker Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Claudia Gebhardt Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Josef Köhrle Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Dagmar Führer Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Karen Steinhoff Department of Nuclear Medicine, University of Leipzig, Germany

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Swen Hesse Department of Nuclear Medicine, University of Leipzig, Germany
IFB Adiposity Diseases, Leipzig University Medical Centre, Leipzig, Germany

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Lars C. Moeller Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Anke Tönjes Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Treatment For the induction of thyrotoxicosis, mice received L -thyroxine at a dose of 2 µg/ml diluted in drinking water for 4 weeks. Hypothyroidism was induced in 10-week-old mice by feeding iodine-free chow supplemented with 0.15% PTU (catalog TD 97061

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000437304
Volume/Issue:
Volume 4: Issue 1_Suppl
Free access