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normal thyroid-stimulating hormone (TSH) and free levothyroxine (fT 4 ) level. In most cases patients are satisfactorily managed with a single dose of levothyroxine daily. The average treatment dosage of levothyroxine is 1.6 μg/kg body weight daily
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Laboratory of Social Pharmacy and Public Health, School of Pharmacy, University of Coimbra, Coimbra, Portugal
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Laboratory of Social Pharmacy and Public Health, School of Pharmacy, University of Coimbra, Coimbra, Portugal
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Introduction Hypothyroidism is a condition of thyroid hormone deficiency which is essentially defined based on biochemical parameters. Overt hypothyroidism is the combination of an elevated level of serum thyroid-stimulating hormone (TSH) with
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thyroid-stimulating hormone (TSH) levels in a range of 0.3–2.0 mU/L. Family physicians are directed to refer the patients back to the tertiary care clinic if there is evidence of recurrence on US or if TG becomes detectable. For the purpose of this study
Research Institute Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, the Netherlands
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Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center, Boston, Massachusetts, USA.
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Department of Pediatric Endocrinology. Emma children’s hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
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Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
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The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA
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The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA
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Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
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Research Institute Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, the Netherlands
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Introduction Isolated central congenital hypothyroidism (CH) is characterized by decreased serum thyroid hormone (TH) concentrations in combination with a normal, low or slightly elevated serum thyroid stimulating hormone (TSH) due to a defect
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-treated patients and may lead to reduced compliance with the instructions of taking levothyroxine on an empty stomach and at least 30 min before eating and drinking, which in turn may lead to an increase in plasma thyroid-stimulating hormone (TSH) post-Ramadan, as
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Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
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the 1970s [ 2 ]. Most programs employ a thyroid-stimulating hormone (TSH)-based strategy aiming at detection of CH-T [ 3 ]. However, newborns with CH-C – who typically have a low T4 in combination with a normal TSH concentration – will be missed [ 2
Department of Endocrinology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium
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Introduction Endogenous subclinical hyperthyroidism (eSCH) is a common disease defined as persistent low serum thyroid-stimulating hormone (TSH), with normal levels of free thyroxine (fT4) and tri-iodothyronine (fT3) regardless of the presence
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Developmental Endocrinology Research Group, Institute of Child Health, University College London, London, UK
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, 6 ], so early diagnosis and instigation of therapy are essential to allow normal neurodevelopment. The UK Newborn Screening Programme Centre (UKNSPC) has defined standards for the screening process [ 2 , 7 ], using thyroid-stimulating hormone (TSH
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setting, but some controversy remains about the management of subclinical hypothyroidism (SCH). The European Thyroid Association (ETA) recommends treating SCH with levothyroxine (LT4) to normalize maternal serum thyroid-stimulating hormone (TSH) values
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
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Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
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Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
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Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
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Introduction Thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family, whose members harbor the shared α subunit and a unique β subunit. The TSH β subunit, encoded by human TSHB , is a protein of 138 amino acids, that is