Brigitte Decallonne
Brigitte Decallonne
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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Annick Van den Bruel
Annick Van den Bruel
Department of Endocrinology, General Hospital St Jan, Bruges, Belgium
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Gilles Macq
Gilles Macq
Department of Research, Belgian Cancer Registry, Brussels, Belgium
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Nathalie Elaut
Nathalie Elaut
Department of Research, Belgian Cancer Registry, Brussels, Belgium
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Harlinde De Schutter
Harlinde De Schutter
Department of Research, Belgian Cancer Registry, Brussels, Belgium
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identified by either a charged thyroid FNA procedure or thyroid cytology analysis in the year preceding surgery. In comparison to our previously published results, cytology analyses were added as the result of a cross validation of the HIC-retrieved FNA
Daniela Cavaco
Daniela Cavaco
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
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Ana Filipa Martins
Ana Filipa Martins
Department of Endocrinology and Diabetes, Hospital da Luz, Lisbon, Portugal
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Rafael Cabrera
Rafael Cabrera
Department of Patology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
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Helena Vilar
Helena Vilar
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
Nova Medical School, Lisbon, Portugal
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Nova Medical School, Lisbon, Portugal
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ultrasound (US), cytological evaluation, or surgical exploration identified lymph node disease. Histological specimens were analyzed according to World Health Organization (WHO) classification criteria. All patients were treated with 131 iodine (I) after
Pedro Weslley Rosario
Pedro Weslley Rosario
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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Gabriela Franco Mourão
Gabriela Franco Mourão
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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Maria Regina Calsolari
Maria Regina Calsolari
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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radiologist experienced in thyroid imaging. All suspected lesions apparent on the scans were evaluated by US-guided FNA (cytology and Tg). True-positive US findings were defined based on the results of cytology, FNA-Tg, and histology. Assays
Marie Alix Balay
Marie Alix Balay
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Patrick Aidan
Patrick Aidan
American Hospital of Paris, Neuilly sur Seine, France
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Marie Helene Schlageter
Marie Helene Schlageter
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Odette Georges
Odette Georges
American Hospital of Paris, Neuilly sur Seine, France
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Taly Meas
Taly Meas
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Maroun Bechara
Maroun Bechara
American Hospital of Paris, Neuilly sur Seine, France
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Marie Elisabeth Toubert
Marie Elisabeth Toubert
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Isabelle Faugeron
Isabelle Faugeron
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Herve Monpeyssen
Herve Monpeyssen
American Hospital of Paris, Neuilly sur Seine, France
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Cécile N. Chougnet
Cécile N. Chougnet
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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included. The most common indication of thyroidectomy was pathological preoperative cytology (suspicious or malignant) in 27 cases, suspicious nodule on ultrasonography (with indeterminate cytology or without cytology) in 10 cases, and fortuitous
Vittoria Guarda
Vittoria Guarda
Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany
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Anja Pickhard
Anja Pickhard
Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany
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Melanie Boxberg
Melanie Boxberg
Institute of Pathology, Technical University of Munich, Munich, Germany
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Katja Specht
Katja Specht
Institute of Pathology, Technical University of Munich, Munich, Germany
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Anna Maria Stefanie Buchberger
Anna Maria Stefanie Buchberger
Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany
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performed in 4 cases (30.77%), with consistent findings of a cold area with no iodine uptake. A CT scan was obtained in 9 cases (69.23%), and MRI in just 1 case (7.69%). As an initial diagnostic test, 7 patients underwent fine needle aspiration cytology
Enrico Papini
Enrico Papini
Department of Endocrinology and Metabolism, Regina Apostolorum Hospital, Rome, Italy
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Hervé Monpeyssen
Hervé Monpeyssen
Thyroid Unit, American Hospital, Paris, France
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Andrea Frasoldati
Andrea Frasoldati
Department of Endocrinology and Metabolism, Arcispedale Santa Maria Nuova IRCCS-ASL, Reggio Emilia, Italy
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Laszlo Hegedüs
Laszlo Hegedüs
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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Scope of the Document Thyroid nodules are common in the adult population with a prevalence at ultrasound (US) examination of up to 50% in adult females and 30% in males [ 1 - 3 ]. Most lesions are cytologically benign and neither cause local
Rania Mehanna
Rania Mehanna
Departments of Otolaryngology, South Infirmary Victory University Hospital, Cork, Ireland
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Matthew S. Murphy
Matthew S. Murphy
Endocrinology, South Infirmary Victory University Hospital, Cork, Ireland
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Patrick Sheahan
Patrick Sheahan
Departments of Otolaryngology, South Infirmary Victory University Hospital, Cork, Ireland
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cancer diagnosis (19 cases); Thy-3 cytology (33 cases); Graves' disease (18 cases); amiodarone-induced hyperthyroidism (2 cases); goitre with compressive symptoms (21 cases); large size of dominant nodule (18 cases); repeated inadequate cytology (Thy-1
Mohamed Abdouh
Mohamed Abdouh
Cancer Research Program, McGill University Health Centre-Research Institute, Montreal, Québec, Canada
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Roger Tabah
Roger Tabah
Department of Surgery and Department of Oncology, McGill University Health Centre, Montreal, Québec, Canada
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Vincenzo Arena
Vincenzo Arena
Department of Obstetrics and Gynecology, Santo Bambino Hospital, Catania, Italy
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Manuel Arena
Manuel Arena
Fondazione Istituto G. Giglio Cefalù, Pisciotto, Italy
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Zu-hua Gao
Zu-hua Gao
Department of Pathology, McGill University Health Centre-Research Institute, Montreal, Québec, Canada
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Aurelio Lorico
Aurelio Lorico
College of Medicine, Touro University Nevada, Henderson, Nevada, USA
Istituto Oncologico del Mediterraneo, Viagrande, Italy
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Istituto Oncologico del Mediterraneo, Viagrande, Italy
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Goffredo Orazio Arena
Goffredo Orazio Arena
Fondazione Istituto G. Giglio Cefalù, Pisciotto, Italy
Istituto Oncologico del Mediterraneo, Viagrande, Italy
Department of Surgery, McGill University, St. Mary Hospital, Montreal, Québec, Canada
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Istituto Oncologico del Mediterraneo, Viagrande, Italy
Department of Surgery, McGill University, St. Mary Hospital, Montreal, Québec, Canada
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difficulty in distinguishing benign from malignant tumors. Investigations such as fine needle aspiration cytology and MRI scans provide some useful information, but most cases will require surgical excision as a means of coming to a definitive diagnosis
Cláudia C.D. Nakabashi
Cláudia C.D. Nakabashi
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil
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Teresa S. Kasamatsu
Teresa S. Kasamatsu
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Felipe Crispim
Felipe Crispim
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Claudia A. Yamazaki
Claudia A. Yamazaki
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Cléber P. Camacho
Cléber P. Camacho
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Danielle M. Andreoni
Danielle M. Andreoni
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Rosalia P. Padovani
Rosalia P. Padovani
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Elza S. Ikejiri
Elza S. Ikejiri
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Maria C.O.M. Mamone
Maria C.O.M. Mamone
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Flávia C. Aldighieri
Flávia C. Aldighieri
Fleury Medicina e Saúde, São Paulo, Brazil
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Jairo Wagner
Jairo Wagner
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Jairo T. Hidal
Jairo T. Hidal
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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José G.H. Vieira
José G.H. Vieira
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicina e Saúde, São Paulo, Brazil
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Fleury Medicina e Saúde, São Paulo, Brazil
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Rosa P.M. Biscolla
Rosa P.M. Biscolla
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil
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Rui M.B. Maciel
Rui M.B. Maciel
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil
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of 131 I and then submitted to WBS. The patients with suspicious images on US that were confirmed as metastases by fine-needle aspiration cytology (FNAC) and Tg measurements of the needle washing fluid (FNA-Tg) underwent lymph node surgery
Tommaso Piticchio
Tommaso Piticchio
Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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Gilles Russ
Gilles Russ
Department of Thyroid and Endocrine Tumor Diseases, La Pitie-Salpetriere Hospital, 83 Bd de l’Hopital, Paris, France
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Maija Radzina
Maija Radzina
Riga Stradins University, Radiology Research Laboratory, Riga, Latvia
University of Latvia, Faculty of Medicine, Riga, Latvia
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University of Latvia, Faculty of Medicine, Riga, Latvia
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Francesco Frasca
Francesco Frasca
Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy
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Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Pierpaolo Trimboli
Pierpaolo Trimboli
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland
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Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland
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risks; (3) assess TNs according to risk classes; and (4) select TNs for fine needle aspiration cytology (FNAC) ( 7 ). The advent of TIRADSs has resulted in a substantial increase in published papers, thereby strengthening the evidence in the field. In
