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Shi Hui Junice Wong Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore

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bilateral tender lymphadenopathy, worse on the left. Oral cavity and nasoendoscopy examination were unremarkable. Fine-needle aspiration of the left cervical lymph node showed a predominantly neutrophilic infiltrate compatible with acute inflammation

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Darshan Patil Department of Surgical Oncology, HCG-Bangalore Institute of Oncology, Bangalore, India

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Abhay Kumaraswamy Kattepur Department of Surgical Oncology, HCG-Bangalore Institute of Oncology, Bangalore, India

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Srinivas Kodaganur Gopinath Department of Surgical Oncology, HCG-Bangalore Institute of Oncology, Bangalore, India

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Shivanand Swamy Department of Surgical Oncology, HCG-Bangalore Institute of Oncology, Bangalore, India

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Amarendra Shankarappa Department of Surgical Oncology, HCG-Bangalore Institute of Oncology, Bangalore, India

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Gopinath Kodaganur Srinivasachar Department of Surgical Oncology, HCG-Bangalore Institute of Oncology, Bangalore, India

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in both the lobes. She was clinically euthyroid. X-ray of the left digit showed multiple lytic lesions in the terminal phalanx. Fine-needle aspiration cytology (FNAC) of the thyroid revealed follicular carcinoma. Biopsy from the growth in the little

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Massimiliano Andrioli Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano

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Chiara Carzaniga Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano

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Luca Persani Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano
Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy

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performing and not directly performing thyroid US in immediately and better identifying the nodules (those classified as borderline, suspicious of malignancy or malignant) worthy of further investigations (i.e. fine-needle aspiration and cytology), and

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Yanping Ma Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, China

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Tao Wu Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, China

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Zhicheng Yao General Surgery Department, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, China

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Bowen Zheng Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, China

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Lei Tan Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, China

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Ge Tong Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, China

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Yufan Lian Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, China

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Jung Hwan Baek Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Jie Ren Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, China

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). Fig. 1. Flowchart of patient enrollment. RFA, radiofrequency ablation. Pretreatment Evaluation Before the procedure, the ultrasonography (US) findings, fine-needle aspiration findings, contrast-enhanced US (CEUS) findings, and

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Milan Halenka Department of Internal Medicine III – Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Olomouc, Czech Republic
Department of Internal Medicine III – Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

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Hana Munteanu Department of Internal Medicine III – Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

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Radko Obereigneru Faculty of Arts, Palacky University Olomouc, Olomouc, Czech Republic

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Roman Dohnal Department of Internal Medicine III – Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Olomouc, Czech Republic
Department of Internal Medicine III – Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

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David Karasek Department of Internal Medicine III – Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Olomouc, Czech Republic
Department of Internal Medicine III – Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

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Jan Schovanek Department of Internal Medicine III – Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Olomouc, Czech Republic
Department of Internal Medicine III – Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

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patients with thyroid nodules have local mechanical problems from compression or perceive the appearance of the neck as a cosmetic problem ( 6 ). If the cause of the complaints is a cystic thyroid nodule, fine needle aspiration biopsy (US-FNAB) is performed

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Shigenobu Nagataki Nagasaki University, Ito Hospital, and Radiation Effects Association, Tokyo, Japan

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on March 11, 2011) [ 3 , 4 ]. The participation rate was 81.7% (300,476 of 367,672 children), and 116 patients (39 males and 77 females) were identified as having malignant or suspected malignant thyroid nodules (by ultrasound examination and fine-needle

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Saleha Babli Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada
Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia

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Richard J.  Payne Department of Otolaryngology, Royal Victoria Hospital, McGill University, Montreal, Québec, Canada

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Elliot Mitmaker Department of Surgery, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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Juan Rivera Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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Patients Total thyroidectomy was performed in all patients with malignancy or suspicious for malignancy confirmed by preoperative fine-needle aspiration biopsy. Patients in whom the initial surgical procedure was lobectomy underwent completion

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Helmi Khadra Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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Ahmed Deniwar Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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Khuzema Mohsin Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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Dominique Monlezun Tulane University School of Medicine, New Orleans, Louisiana, USA

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Emad Kandil Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA

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benign nodules, which can be managed conservatively. Suspicious US features described to select nodules with malignancy potential to undergo fine needle aspiration (FNA) included hypoechogenicity, microcalcifications, irregular margins, non

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Mario Monaco Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale', IRCCS, Italy

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Gennaro Chiappetta Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale', IRCCS, Italy

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Concetta Aiello Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale', IRCCS, Italy

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Antonella Federico Istituto per l'Endocrinologia e l'Oncologia Sperimentale (IEOS), Consiglio Nazionale delle Ricerche (CNR), c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), Università degli Studi di Napoli ‘Federico II', Naples, Italy

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Romina Sepe Istituto per l'Endocrinologia e l'Oncologia Sperimentale (IEOS), Consiglio Nazionale delle Ricerche (CNR), c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), Università degli Studi di Napoli ‘Federico II', Naples, Italy

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Daniela Russo Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale', IRCCS, Italy

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Alfredo Fusco Istituto per l'Endocrinologia e l'Oncologia Sperimentale (IEOS), Consiglio Nazionale delle Ricerche (CNR), c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), Università degli Studi di Napoli ‘Federico II', Naples, Italy
Instituto Nacional de Câncer - INCA, Rio de Janeiro, Brazil

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Pierlorenzo Pallante Istituto per l'Endocrinologia e l'Oncologia Sperimentale (IEOS), Consiglio Nazionale delle Ricerche (CNR), c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), Università degli Studi di Napoli ‘Federico II', Naples, Italy

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carcinoma, oxyphilic type. Distinguishing a benign neoplasm from a malignant neoplasm based on cytologic analysis of fine-needle aspiration biopsy is not possible. Features such as pleomorphism, anaplasia, hyperchromatism, and atypia are also observed in

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Rima Bėrontienė Clinics of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Edita Jašinskienė Clinics of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Rosita Kiudelienė Clinics of Pediatrics, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Gintaras Kuprionis Clinics of Radiology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Jurgita Makštienė Clinics of Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Raminta Macaitytė Clinics of Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Dalia Marčiulionytė Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Lina Poškienė Clinics of Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Agnė Šemetaitė Clinics of Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Vygantas Šidlauskas Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Raimondas Valickas Clinics of Radiology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Rimantas Žalinkevičius Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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Rasa Verkauskienė Clinics of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania
Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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left lobe (47.37%), p = 0.73]. Nodule microcalcification was seen in 14 cases (24.56%), irregular margins in 47 cases (82.46%), active blood flow in 38 cases (66.67%), and reactive regional lymph nodes in 4 cases (7.02%). Fine-Needle Aspiration

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