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Germán A. Jimenez Londoño Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Ana Maria Garcia Vicente Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Julia Sastre Marcos Department of Endocrinology, Complejo Hospitalario de Toledo, Toledo, Spain

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Francisco Jose Pena Pardo Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Mariano Amo-Salas Department of Mathematics, University of Castilla-La Mancha, Ciudad Real, Spain

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Manuel Moreno Caballero Department of Nuclear Medicine, Hospital Universitario Infanta Cristina Badajoz, Badajoz, Spain

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Maria Prado Talavera Rubio  Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Beatriz Gonzalez Garcia Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Niletys Dafne Disotuar Ruiz Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Angel Maria Soriano Castrejón Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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underwent RRA after thyroid hormone withdrawal (THW) or administration of recombinant human thyroid-stimulating hormone (rhTSH). pTg, pAntiTgAb and preablation TSH (pTSH) levels were measured. Patients were required to have TSH levels > 30 mU/L at the time

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000489850
Volume/Issue:
Volume 7: Issue 4
Free access
Diogo Mendes Center for Health Technology Assessment and Drug Research, Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal

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Carlos Alves Center for Health Technology Assessment and Drug Research, Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
Laboratory of Social Pharmacy and Public Health, School of Pharmacy, University of Coimbra, Coimbra, Portugal

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Nuno Silverio Merck S.A., Algés, Portugal

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Francisco Batel Marques Center for Health Technology Assessment and Drug Research, Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
Laboratory of Social Pharmacy and Public Health, School of Pharmacy, University of Coimbra, Coimbra, Portugal

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severe subclinical hypothyroidism [ 2 , 22 - 24 ]. Moreover, the TSH concentration usually normalizes within 2 years for 46% of patients with subclinical hypothyroidism if the TSH level is <7 mIU/L in a single measurement [ 61 - 63 ]. Yet, the risk of

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000499751
Volume/Issue:
Volume 8: Issue 3
Free access
Ladan Mehran Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Atieh Amouzegar Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Hengameh Abdi Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Negar Delbari Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Elham Madreseh Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

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Maryam Tohidi Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Mohammad Ali Mansournia Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

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Fereidoun Azizi Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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-monitored salt iodization program in Iran: marked reduction in goiter prevalence and eventual normalization of urinary iodine concentrations without alteration in iodine content of salt . J Endocrinol Invest . 2008 May ; 31 ( 5 ): 422 – 31 . http

Article Type:
Research Article
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1159/000512665
Volume/Issue:
Volume 10: Issue 5
Free access
Georgios K. Markantes Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece

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Konstantinos Dimitropoulos Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece

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Irene Mamali Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece

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Ioulia Tseti Uni-Pharma S.A., Athens, Greece

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George Sakellaropoulos Department of Medical Physics, School of Medicine, University of Patras, Patras, Greece

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Kostas B. Markou Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece

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Marina A. Michalaki Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece

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thereafter. They were also instructed not to take their LT4 preparation before blood sampling on the scheduled visits for thyroid hormone measurements. We set the therapeutic target range of TSH levels at 0.45–4.12 mIU/L [ 8 ], since Greece is an iodine

Article Type:
Research Article
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1159/000508216
Volume/Issue:
Volume 10: Issue 1
Free access
Anita Boelen Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Nitash Zwaveling-Soonawala Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands

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Annemieke C Heijboer Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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A S Paul van Trotsenburg Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands

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sufficient TH concentrations at the cellular level. Therefore, the necessity of TH replacement therapy remains uncertain now, although concentration, energy level and signs of myxoedema of one patient improved after starting T4 replacement therapy, which

Article Type:
Review Article
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1530/ETJ-23-0041
Volume/Issue:
Volume 12: Issue 4
Open access
Ilaria Muller Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Anita Daturi Department of Clinical Sciences and Community Health, University of Milan, Italy

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Matteo Varallo Department of Clinical Sciences and Community Health, University of Milan, Italy

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Tiziana E Re Internal Medicine - High Intensity of Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Davide Dazzi Casa di Cura Val Parma SRL, Langhirano (Parmigiano: Langhiràn), Italy

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Sara Maioli Department of Clinical Sciences and Community Health, University of Milan, Italy

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Erica Crivicich Department of Clinical Sciences and Community Health, University of Milan, Italy

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Francesco Di Marco Department of Clinical Sciences and Community Health, University of Milan, Italy

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Virgilio Longari Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Beatrice Dazzi Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Massimo Castellani Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Giovanna Mantovani Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Maura Arosio Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy

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Mario Salvi Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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function tests in the context of euthyroidism, due to a complex combination of adaptive and maladaptive mechanisms, known as non-thyroidal illness syndrome (NTIS) and characterised by low serum concentrations of total and free-triiodothyronine (FT3

Article Type:
Research Article
Collections:
Thyroid function tests
DOI:
https://doi.org/10.1530/ETJ-22-0200
Volume/Issue:
Volume 12: Issue 2
Open access
Clotilde Saïe Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Cécile Ghander Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Samir Saheb Apheresis Unit, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France

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Christel Jublanc Department of Endocrinology, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Denis Lemesle Department of Anaesthesia, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Charlotte Lussey-Lepoutre Nuclear Medicine Department, Pitié-Salpêtrière Hospital APHP, Sorbonne Université, Inserm U970, Paris, France

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Laurence Leenhardt Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Fabrice Menegaux Department of Surgery, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Christophe Tresallet Department of Surgery, Avicennes Hospital, Paris, France

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Camille Buffet Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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thyrotoxicosis). In the patients with GD, the median TSH receptor antibody level was 16 U/L (range 9–41 U/L). All patients with AIT had type 2 AIT, confirmed by 123 -iodine thyroid scintigraphy (online suppl. Fig.; www.karger.com/doi/10.1159/000507019) or

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000507019
Volume/Issue:
Volume 10: Issue 1
Free access
Claudio Marcocci Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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Marenza Leo Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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Maria Antonietta Altea Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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), MDA, and tert-butyl hydroperoxide-initiated chemiluminescence. The levels of lipid peroxidation products correlate with serum concentration of thyroid hormones in patients with symptomatic hyperthyroidism, but significantly higher values have also been

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000337976
Volume/Issue:
Volume 1: Issue 2
Free access
Estefanía Rinaldini Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina

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Fiorella Campo Verde Arboccó Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina

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Marcelo Ezquer Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile

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Carlos Gamarra-Luques Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina
Facultad de Ciencias Médicas, Instituto de Fisiología, Universidad Nacional de Cuyo, Mendoza, Argentina

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María Belén Hapon Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina
Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Mendoza, Argentina

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control levels. All groups had lower T3 levels than controls on L14. At the end of lactation, only T3 remained at control levels in the GC-1 group. Fig. 1. TSH and T3 serum concentrations in rats during gestation and lactation treated with

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000516432
Volume/Issue:
Volume 10: Issue 5
Free access
Chae Won Chung Department of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea
Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea

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Kyungsik Kim Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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Sue K Park Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Seoul, Korea

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Dal Lae Ju Department of Food Service and Nutrition Care, Seoul National University Hospital, Seoul, Korea

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Young Joo Park Department of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea

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Choong Ho Shin Department of Pediatrics, Seoul National University Children’s Hospital and Seoul National University College of Medicine, Seoul, Korea

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Jong Kwan Jun Department of Obstetrics and Gynecology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea

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June-Key Chung Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea

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Yoon Ju Song Department of Food Science and Nutrition, The Catholic University of Korea, Bucheon, Korea

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Young Ah Lee Department of Pediatrics, Seoul National University Children’s Hospital and Seoul National University College of Medicine, Seoul, Korea

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Gi Jeong Cheon Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea

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Sun Wook Cho Department of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea

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concentrations, participants were divided into three groups: deficient, < 70 μg/L; suboptimal, 70–99 μg/L; and optimal, ≥ 100 μg/L. The range of the deficient group was defined by previous studies ( 17 , 18 , 19 ), and the optimal level was set to the

Article Type:
Research Article
Collections:
Thyroid and reproduction
DOI:
https://doi.org/10.1530/ETJ-24-0007
Volume/Issue:
Volume 13: Issue 4
Open access