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Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy
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Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy
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ultrasonographic/clinical profile, cytology, and BRAF V600E mutation evaluation in thyroid nodule screening for malignancy: a prospective study. J Clin Endocrinol Metab 2012; 97: 2354–2361. 7 Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ
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Objective. The ultrasound evaluation of thyroid nodules (TN) in patient selection for fine needle aspiration (FNA) requires both uniformly accepted definitions of each nodule characteristic and extensive experience of the examiner. We hypothesized that nodule echogenicity alone may provide comparable performance to the more complex approaches, in patient selection for FNA.
Patients and Methods. Seven highly experienced investigators from four countries evaluated, online, the ultrasound (US) video recordings of 123 histologically verified TN, by answering 17 nodule characteristics-related questions. The diagnostic performances of five TN image reporting and data systems (TIRADS) were compared to making decisions based alone on echogenicity of the nodule, for indicating FNA in 110 nodules ≥10 mm.
Results. In the 10 to 20 mm size range, the sensitivities and specificities of the five TIRADS systems in identifying malignant nodules was 80.5%-91.0%, and 31.4-50.9%, respectively. Had FNA been recommended in all hypoechoic nodules, disregarding other US characteristics, comparable sensitivity and specificity (87.5% and 43.4%, respectively) were obtained. Compared to nodules >20mm, a higher proportion of cancers were hypoechoic in the 10 to 20 mm size range (87.2% vs. 77.8%, p=0.05). In the 10-20 mm size range, compared to hypoechoic nodules, a significantly lower proportion of isoechoic nodules demonstrated suspicious findings (70.7% vs. 30.0%, p<0.05).
Conclusion. In contrast to >20 mm diameter nodules, the recommendation of FNA may rely on a single US feature, echogenicity, in the 10-20 mm size range. If independently confirmed in larger cohorts, this may simplify nodule evaluation in this size range.
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tomography (FDG-PET) with integrated unenhanced CT scan. Although there was no thyroid signal on FDG PET, we noticed that in the unenhanced CT scan the thyroid had become 'white', suggesting that intrathyroid accumulation of iodine brought by amiodarone acted
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Introduction Thyroid nodules (TNs) are commonly detected via high-resolution ultrasonography (US) and affect approximately 70% of the general population ( 1 , 2 ). Although most are benign TNs (BTNs) and asymptomatic, a noticeable but small
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Introduction Thyroid nodules are a common clinical problem. Epidemiological studies have shown that the prevalence of palpable thyroid nodules is approximately 5% [ 1 , 2 ]; however, the frequency of incidental discovery using ultrasound (US
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growing incidence – caused almost exclusively by low-mortality papillary tumours – accurate diagnostic methods become increasingly important in order to deal with the growing number of patients [ 3 , 4 ]. Preoperative assessment of thyroid nodules
Nuclear Medicine, Radiology Department, San Francisco VA Medical Center, San Francisco, Calif., USA
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X-ray was suspicious for pulmonary nodules and this was confirmed by dedicated CT imaging of the chest, which also demonstrated a multinodular goiter. Thyroid ultrasound showed multiple nodules and a fine-needle aspiration of one of the dominant
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Introduction Radiological scans of the neck (ultrasound (US), computed tomography and magnetic resonance imaging), in many cases carried out for reasons unrelated to the thyroid gland, lead to the finding of many thyroid nodules, both palpable
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disease is to find a way to distinguish preoperatively benign nodules (>90%) from cancers [ 1 , 2 , 3 , 4 ]. The management of thyroid diseases has significantly changed over the past 30 years due to the widespread availability of novel diagnostic and
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The 2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma ( 1 ) were developed by a task force comprising well-respected, expert clinicians with good representation of the
