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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
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, radioactive iodine; WBS, whole-body scan. She received 100 mCi of radioactive iodine (RAI) with recombinant TSH. The stimulated Tg was 7.5 ng/mL and the post-RAI whole-body scan showed a moderate cervical residual uptake (as presented in Fig. 1
Center of Brain, Behavior and Metabolism (CBBM)/Medizinische Klinik I, University of Lübeck, Lübeck, Germany
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Center of Brain, Behavior and Metabolism (CBBM)/Medizinische Klinik I, University of Lübeck, Lübeck, Germany
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Institute for Experimental Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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derivatives 3-iodothyronamine (3-T 1 AM) and the iodine-free thyronamine (T 0 AM) have been detected in vivo, e.g., in the brain, heart, liver, and blood of male C57BL/6J mice [ 1 ]. Nevertheless, the effects of T 0 AM are much less studied compared to 3-T 1
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within 4 weeks of their deliveries and cord FT4 level of their infants at the time of delivery were available. Those who had multiple pregnancies, fetal goiter detected by ultrasonography, iodine or glucocorticoid treatment, and change in ATD after the
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Institut National de la Recherche Médicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France
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Dear Editor, We read with interest the comments and suggestions of Dinc et al. [ 1 ] regarding our paper [ 2 ]. The authors state that an iodine supplementation of 150 μg/day was not adequate in women included in our study. However, this
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Dear Sir, The word ‘cretin' was initially used for mentally retarded, deaf-mute and usually goitrous individuals born and living in areas of very severe iodine deficiency [ 1 ]. It is believed to have originated from ‘Pauvre Chrétienne' (a
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WHO. Nationally, he was member of a committee of the Gezondheidsraad (Health Council) advising on iodine supply, radioactive iodine prophylaxis, and iodine prophylaxis in nuclear accidents. His tutorship of students, residents, and colleagues was of
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Granada. He completed his doctoral thesis on the administration of iodized salt in the iodine-deficient region of Alpujarras under the mentorship of Prof. Ortiz de Landazuri. From then on, his scientific career has been inseparable from that of his wife
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Objective: Image-guided interventional ultrasound (US) techniques represent diagnostic and therapeutic tools for non-surgical management of thyroid nodular disease. We sought to investigate the attitude of European Thyroid Association (ETA) members towards the use of minimally invasive techniques (MIT) in diagnosis/therapy of symptomatic nodular goitre. Methods: ETA members were invited to participate in an online survey investigating the use of MIT in benign and malignant thyroid nodular disease. Of 865 invited members, 221 (25.5%) completed the survey. The respondents were from 40 countries; 139 (74.7%) were from European countries. Results: Respondents personally performed thyroid US (91.6%), Fine needle aspiration (FNA; 75.3%), ethanol ablation (EA; 22.1%), core needle biopsy (CNB; 11%) and thermal treatments (4.8%). When skills and/or technology were unavailable, only 13.4% referred patients “often” or “always” to other centres with specific expertise in this field. Surgery was the preferred first option in patients with recurrent cysts, 4.0 cm benign nodules, local (radioiodine-avid or non-avid) lymph node metastases, or papillary cancers <1.0 cm. For autonomously functioning nodules radioactive iodine treatment was the preferred choice, followed by surgery. Thermal ablation (TA) was the preferred option only for a 4 cm benign nodule in old patients with comorbidities. Conclusions: US, US-guided FNA and surgery were available to nearly all respondents, while MIT was not. CNB and EA were employed only by about 1/3 of the respondents and TA procedures were available and personally performed only by a minority. For most thyroid lesions, surgery was the preferred option versus thermal therapies. The ETA needs to develop guidelines and establish teaching to overcome geographic inequality and promote the use of MIT as a valid therapy option in appropriate cases.
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Objective: As thionamide is associated with various adverse effects, we reevaluated the practical efficacy of potassium iodide (KI) therapy for Graves’ hyperthyroidism (GD).
Methods: We administered KI (mainly 100 mg/day) to 324 untreated GD patients, and added methimazole (MMI) only to those remaining thyrotoxic even at 200 mg/day. When the patient became hypothyroid, MMI if taken was stopped, then levothyroxine (LT4) was added without reducing the KI dose. Radioactive iodine (RI) therapy or thyroidectomy was performed whenever required. We evaluated the early effects of KI at 2-4 weeks, and followed patients for 2 years.
Results: At 2 weeks, serum thyroid hormone decreased in all 324 patients. At 4 weeks, fT4, fT3, and both fT4 and fT3 levels became normal or low in 74.7%, 50.6%, and 50.6%, respectively. In a cross-sectional survey over 2-years, GD was well-controlled with KI or KI+LT4 (KI-effective) in >50% of patients at all time points. Among 288 patients followed for 2 years, 42.7% remained ‘KI-effective’ throughout 2 years (KI Group), 30.9% were well-controlled with additional MMI given for 1-24 months, and 26.4% were successfully treated with ablative therapy (mainly RI). Among ‘KI-effective’ patients at 4 weeks, 76.5% were classified into KI Group. No patients experienced adverse effects of KI.
Conclusion: KI therapy was useful in the treatment of GD. A sufficient dose of KI was effective in >50% of GD patients from 4 weeks to 2 years, and 42.7% (76.5% of ‘KI effective’ patients at 4 weeks) remained ‘KI-effective’ throughout 2 years.
in several research areas. In the early days of his clinical training he met a colleague from Iceland, who became a good friend and with whom he entered a prosperous research collaboration studying the consequences of differences in iodine intake
