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Clotilde Saïe Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Cécile Ghander Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Samir Saheb Apheresis Unit, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France

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Christel Jublanc Department of Endocrinology, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Denis Lemesle Department of Anaesthesia, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Charlotte Lussey-Lepoutre Nuclear Medicine Department, Pitié-Salpêtrière Hospital APHP, Sorbonne Université, Inserm U970, Paris, France

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Laurence Leenhardt Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Fabrice Menegaux Department of Surgery, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Christophe Tresallet Department of Surgery, Avicennes Hospital, Paris, France

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Camille Buffet Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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thyrotoxicosis). In the patients with GD, the median TSH receptor antibody level was 16 U/L (range 9–41 U/L). All patients with AIT had type 2 AIT, confirmed by 123 -iodine thyroid scintigraphy (online suppl. Fig.; www.karger.com/doi/10.1159/000507019) or

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Kerstin Krause Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Juliane Weiner Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Sebastian Hönes Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Nora Klöting Division of Endocrinology and Nephrology, Department of Medicine, Germany
IFB Adiposity Diseases, Leipzig University Medical Centre, Leipzig, Germany

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Eddy Rijntjes Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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John T. Heiker Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Claudia Gebhardt Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Josef Köhrle Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Dagmar Führer Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Karen Steinhoff Department of Nuclear Medicine, University of Leipzig, Germany

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Swen Hesse Department of Nuclear Medicine, University of Leipzig, Germany
IFB Adiposity Diseases, Leipzig University Medical Centre, Leipzig, Germany

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Lars C. Moeller Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Anke Tönjes Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Treatment For the induction of thyrotoxicosis, mice received L -thyroxine at a dose of 2 µg/ml diluted in drinking water for 4 weeks. Hypothyroidism was induced in 10-week-old mice by feeding iodine-free chow supplemented with 0.15% PTU (catalog TD 97061

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Sara Donato Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal

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Helder Simões Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

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Valeriano Leite Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal

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, radioactive iodine; WBS, whole-body scan. She received 100 mCi of radioactive iodine (RAI) with recombinant TSH. The stimulated Tg was 7.5 ng/mL and the post-RAI whole-body scan showed a moderate cervical residual uptake (as presented in Fig.  1

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Lisbeth Harder Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
Center of Brain, Behavior and Metabolism (CBBM)/Medizinische Klinik I, University of Lübeck, Lübeck, Germany

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Nancy Schanze Institute for Experimental Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Assel Sarsenbayeva Institute for Experimental Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Franziska Kugel Institute for Experimental Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Josef Köhrle Institute for Experimental Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Lutz Schomburg Institute for Experimental Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Jens Mittag Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
Center of Brain, Behavior and Metabolism (CBBM)/Medizinische Klinik I, University of Lübeck, Lübeck, Germany

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Carolin S. Hoefig Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
Institute for Experimental Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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derivatives 3-iodothyronamine (3-T 1 AM) and the iodine-free thyronamine (T 0 AM) have been detected in vivo, e.g., in the brain, heart, liver, and blood of male C57BL/6J mice [ 1 ]. Nevertheless, the effects of T 0 AM are much less studied compared to 3-T 1

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Hiroyuki Iwaki Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Kenji Ohba Medical Education Center, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Eisaku Okada Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Takeshi Murakoshi Obstetrics and Gynecology, Maternal and Perinatal Care Center, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Yumiko Kashiwabara Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Chiga Hayashi Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Akio Matsushita Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Shigekazu Sasaki Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Takafumi Suda Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Yutaka Oki Department of Metabolism and Endocrinology, Hamamatsu-Kita Hospital, Hamamatsu, Japan

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Rieko Gemma Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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within 4 weeks of their deliveries and cord FT4 level of their infants at the time of delivery were available. Those who had multiple pregnancies, fetal goiter detected by ultrasonography, iodine or glucocorticoid treatment, and change in ATD after the

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Camilo Fuentes Peña C Fuentes Peña, Nuclear Medicine, Hopital Erasme, Bruxelles, 1070, Belgium

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María Cecilia Opazo M Opazo, Instituto de Ciencias Naturales, Facultad de Medicina Veterinaria y Agronomía , Universidad de Las Americas, Santiago, Chile

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Luis Méndez L Méndez, Millennium Institute on Immunology and Immunotherapy, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile

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Claudia Riedel C Riedel, Millennium Institute on Immunology and Immunotherapy, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile

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Bernard Hauquier B Hauquier, Nuclear Medicine, Hopital Erasme, Bruxelles, Belgium

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Lionel Marcelis L Marcelis, Laboratory of Paediatric Research, Hopital Universitaire des Enfants Reine Fabiola, Bruxelles, Belgium

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Frederic Cotton F Cotton, Clinical Chemestry - LHUB-ULB, Universite Libre de Bruxelles, Bruxelles, Belgium

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Rodrigo Moreno-Reyes R Moreno-Reyes, Nuclear Medicine, Hopital Erasme, Bruxelles, Belgium

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Background: Thyroglobulin (Tg) is a biomarker of iodine status. Newborn Tg is a more sensitive marker than neonatal TSH in detecting variations in iodine intake. This study aims to validate a Tg enzyme-linked immunosorbent assay (ELISA) for Tg determination on dried blood spots (DBS) in newborns. This study also set out to assess the stability of Tg and the influence of newborns’ hematocrit on Tg determination.

Methods: A commercially available ELISA Tg assay was adapted for use on DBS. DBS-Tg in cord blood were measured in 209 newborns delivered from healthy euthyroid pregnant women. Sensitivity, linearity, repeatability, and intermediate fidelity were determined using the appropriate standards and quality control materials.

Results: The limit of detection (LoD) of the DBS-Tg assay was 2.4 µg/L, and the limit of quantification (LoQ) was 5.8 µg/L. Repeatability and intermediate fidelity were 7.7-8.3% and 11.0-11.2%, respectively. The median cord plasma Tg and DBS-Tg values in newborns were not significantly different, 30.2 (21.3-44.4) µg/L and 31.6 (19.3-48.7) µg/L (p=0.48) with the ELISA respectively, and 76.5 (40.0-101.5) µg/L with the Elecsys assay with an R=0.88. DBS-Tg concentrations decrease with increasing hematocrit values (p<0.05). DBS-Tg values were stable at a concentration of 25 µg/L for 12 months at -20ºC and 4ºC.

Conclusion: This DBS-Tg assay demonstrated good analytical performances over a wide range of Tg concentrations, suggesting it is well suited to detecting variations in Tg concentrations. Studies comparing populations with different prevalence of anemia should consider the effect of hematocrit on DBS-Tg determination. The availability of a DBS-Tg assay for newborns makes it possible to integrate iodine status monitoring with newborn screening for inherited metabolic diseases.

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Sylvie Hiéronimus Department of Endocrinology, Diabetology and Reproductive Medicine, University Hospital of Nice

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Françoise Brucker-Davis Department of Endocrinology, Diabetology and Reproductive Medicine, University Hospital of Nice
Institut National de la Recherche Médicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France

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Dear Editor, We read with interest the comments and suggestions of Dinc et al. [ 1 ] regarding our paper [ 2 ]. The authors state that an iodine supplementation of 150 μg/day was not adequate in women included in our study. However, this

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Gabriella Morreale de Escobar CSIC/Fac. Med. UAM, Madrid, Spain

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Dear Sir, The word ‘cretin' was initially used for mentally retarded, deaf-mute and usually goitrous individuals born and living in areas of very severe iodine deficiency [ 1 ]. It is believed to have originated from ‘Pauvre Chrétienne' (a

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Eric P. Krenning
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Roel Docter
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Wouter W. de Herder
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Robin P. Peeters
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Wilmar M. Wiersinga
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WHO. Nationally, he was member of a committee of the Gezondheidsraad (Health Council) advising on iodine supply, radioactive iodine prophylaxis, and iodine prophylaxis in nuclear accidents. His tutorship of students, residents, and colleagues was of

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Juan Bernal
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Granada. He completed his doctoral thesis on the administration of iodized salt in the iodine-deficient region of Alpujarras under the mentorship of Prof. Ortiz de Landazuri. From then on, his scientific career has been inseparable from that of his wife

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