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Sujoy Ghosh Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Subhodip Pramanik Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Kaushik Biswas Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Kingshuk Bhattacharjee Biocon Limited, Bengaluru, India

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Rajib Sarkar School of Digestive and Liver Diseases, Kolkata, India

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Subhankar Chowdhury Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Pradip Mukhopadhyay Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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true malabsorption based on the increment of FT4 at 3 h from baseline in LAT by the ROC curve. In this model, an increment of FT4 at 3 h of >0.40 ng/dL (5.14 pmol/L) had a sensitivity of 97% and specificity of 80% to rule out true malabsorption (AUC 0

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Aamna Hassan Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Saima Riaz Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Humayun Bashir Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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M. Khalid Nawaz Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Raza Hussain Departments of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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abnormality. The false negative rate was 1.7%. One patient had no evidence of FDG avid disease; however, neck dissection confirmed nodal metastases. The diagnostic accuracy of 18 F-FDG PET/CT scan was 94.8%, sensitivity 97.7%, specificity 85.7%, positive

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Simon H.S. Pearce Institute of Genetic Medicine, Newcastle University
Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Georg Brabant Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

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Leonidas H. Duntas Endocrine Unit, Evgenidion Hospital, University of Athens, Athens, Greece

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Fabio Monzani Department of Clinical and Experimental Medicine, Università di Pisa, Pisa, Italy

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Robin P. Peeters Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Salman Razvi Institute of Genetic Medicine, Newcastle University
Queen Elizabeth Hospital, Gateshead, UK

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Jean-Louis Wemeau Clinique Endocrinologique Marc Linquette, CHU, Lille, France

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questions have prompted the European Thyroid Association (ETA) to form a task force with the aim of drawing up guidelines on the management of SCH in adults. A specific guideline on the management of SCH in children and in pregnancy will be prepared

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Laura Fugazzola Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Maurilio Deandrea Endocrinology, Diabetes and Metabolism Department and Center for Thyroid Diseases, Ordine Mauriziano Hospital, Turin, Italy

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Stefano Borgato Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Marco Dell’Acqua Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Francesca Retta Endocrinology, Diabetes and Metabolism Department and Center for Thyroid Diseases, Ordine Mauriziano Hospital, Turin, Italy

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Alberto Mormile Endocrinology, Diabetes and Metabolism Department and Center for Thyroid Diseases, Ordine Mauriziano Hospital, Turin, Italy

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Chiara Carzaniga Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Giacomo Gazzano Pathology Unit, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Gabriele Pogliaghi Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Marina Muzza Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Luca Persani Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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treatment in advanced and infiltrative thyroid tumors ( 4 ). No specific recommendations are available regarding the use of RFA or other mini-invasive procedures in indeterminate nodules (Bethesda III and IV). According to the last Bethesda classification

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Carla Gambale Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Alessandro Prete Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Lea Contartese Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Liborio Torregrossa Department of Surgical, Medical, Molecular Pathology and Critical Area, Anatomic Pathology Section, University Hospital of Pisa, Pisa, Italy

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Francesca Bianchi Department of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy

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Eleonora Molinaro Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Gabriele Materazzi Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Endocrine Surgery, University Hospital of Pisa, Pisa, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Antonio Matrone Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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-Tg) ≥10 ng/mL or rising thyroglobulin antibodies (TgAb) levels with negative imaging; InR were defined by LT4-Tg <1 ng/mL or rhTSH-Tg <10 ng/mL or stable/declining TgAb levels with non-specific findings on imaging or faint radioiodine uptake in thyroid bed

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Roberto Attanasio Endocrine Unit, Galeazzi Orthopedic Institute IRCCS, Milan, Italy

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Endre V. Nagy Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Enrico Papini Department of Endocrinology and Metabolism, Ospedale Regina Apostolorum, Rome, Italy

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Petros Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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would prescribe DTE, whereas T4 + T3 combination therapy was reserved for specific indications (LT4 vs. DTE + T4 + T3; p < 0.01). Ninety-nine per cent of physicians appear to have a major influence on the thyroid management of their patients, since in

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Taha Yusuf Kuzan Department of Radiology, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkey

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Ceren Canbey Goret Department of Surgical Pathology, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkey

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thyroid nodules are benign, and 5–15% of them are thyroid malignancies. Fine-needle aspiration biopsy (FNAB) is a reliable, minimally invasive diagnostic method with high sensitivity and specificity in the evaluation of thyroid nodules [ 2 , 4 - 7

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Doreen Braun Institut für Biochemie und Molekularbiologie, Medizinische Fakultät, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

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Ulrich Schweizer Institut für Biochemie und Molekularbiologie, Medizinische Fakultät, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

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words [ 9 , 22 - 24 ]. We hypothesized that a milder phenotype correlates with decreased protein stability rather than a T 3 -specific transport defect [ 19 , 20 ]. Decreased protein stability would lead to a diminished number of functional MCT8

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Yingxin Fang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Pingping Dang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Yue Liang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Defa Zhao Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Ranran Wang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Yue Xi Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of China

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Dan Zhang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of China

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Wei Wang Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Xiaochun Teng Department of Endocrinology and Metabolism, Institute of Endocrine, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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: identification of genes regulated by triiodothyronine in specific cell types . Cerebral Cortex 2017 27 706 – 717 . ( https://doi.org/10.1093/cercor/bhv273 ) 41 Salazar P Cisternas P Martinez M Inestrosa NC . Hypothyroidism and cognitive disorders

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Juan Antonio Vallejo Casas Department of Nuclear Medicine (UGC), Maimónides Institute of Biomedical Research of Córdoba (IMIBIC), Reina Sofía University Hospital, University of Córdoba, Córdoba, Spain

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Marcel Sambo Department of Endocrinology, Gregorio Marañón University Hospital, Madrid, Spain

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Carlos López López Department of Medical Oncology, Marqués de Valdecilla University Hospital, IDIVAL, Santander, Spain

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Manuel Durán-Poveda Department of General and Digestive Surgery, Rey Juan Carlos University Hospital, Madrid, Spain

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Julio Rodríguez-Villanueva García Oncology Business Group – EISAI Farmacéutica SA, Madrid, Spain

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Rita Joana Santos Department of Endocrinology, Francisco Gentil Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal

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Marta Llanos Department of Medical Oncology, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain

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Elena Navarro-González Department of Endocrinology, Virgen del Rocío University Hospital, Seville, Spain

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Javier Aller Department of Endocrinology, Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain

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Virginia Pubul Department of Nuclear Medicine, University Hospital and Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain

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Sonsoles Guadalix Department of Endocrinology and Nutrition, Hospital Universitario 12 de Octubre, Madrid, Spain

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Guillermo Crespo Department of Medical Oncology, Burgos University Hospital, Burgos, Spain

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Cintia González Department of Endocrinology, Santa Creu i Sant Pau University Hospital, CIBER-BBN, Barcelona, Spain

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Carles Zafón Department of Endocrinology and Nutrition, Vall Hebron University Hospital and Autonomous University of Barcelona (UAB), Barcelona, Spain

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Miguel Navarro Department of Medical Oncology, University Hospital of Salamanca, Salamanca, Spain

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Javier Santamaría-Sandi Department of Endocrinology, Cruces University Hospital, Vizcaya, Spain

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Ángel Segura Medical Oncology Unit, La Fe University Hospital, Valencia, Spain

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Pablo Gajate Department of Medical Oncology, Ramon y Cajal University Hospital, Madrid, Spain

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Marcelino Gómez-Balaguer Department of Endocrinology, Doctor Peset University Hospital, Valencia, Spain

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Javier Valdivia Department of Oncology, University Hospital Centre Virgen de las Nieves, Granada, Spain

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Manel Puig-Domingo Endocrine and Nutrition Service, Health Sciences Research Institute and University Hospital Germans Trias i Pujol, Badalona, Spain

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Juan Carlos Galofré Department of Endocrinology, Clínica Universidad de Navarra, University of Navarra, Lisbon, Spain

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Beatriz Castelo Department of Medical Oncology, La Paz University Hospital, Madrid, Spain

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María José Villanueva Department of Medical Oncology, Alvaro Cunqueiro University Hospital Complex, University of Vigo, Vigo, Spain

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Iñaki Argüelles Department of Endocrinology and Nutrition, Son Espases University Hospital, Palma de Mallorca, Spain

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Lorenzo Orcajo-Rincón Oncology Business Group – EISAI Farmacéutica SA, Madrid, Spain

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eCRF included a range of filters and logical controls to reduce errors, and an authorized Clinical Research Associate helped data entering at various sites. Clinical endpoints of interest included OS and disease-specific survival (DSS), which were

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