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true malabsorption based on the increment of FT4 at 3 h from baseline in LAT by the ROC curve. In this model, an increment of FT4 at 3 h of >0.40 ng/dL (5.14 pmol/L) had a sensitivity of 97% and specificity of 80% to rule out true malabsorption (AUC 0
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abnormality. The false negative rate was 1.7%. One patient had no evidence of FDG avid disease; however, neck dissection confirmed nodal metastases. The diagnostic accuracy of 18 F-FDG PET/CT scan was 94.8%, sensitivity 97.7%, specificity 85.7%, positive
Royal Victoria Infirmary, Newcastle upon Tyne, UK
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Queen Elizabeth Hospital, Gateshead, UK
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questions have prompted the European Thyroid Association (ETA) to form a task force with the aim of drawing up guidelines on the management of SCH in adults. A specific guideline on the management of SCH in children and in pregnancy will be prepared
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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treatment in advanced and infiltrative thyroid tumors ( 4 ). No specific recommendations are available regarding the use of RFA or other mini-invasive procedures in indeterminate nodules (Bethesda III and IV). According to the last Bethesda classification
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-Tg) ≥10 ng/mL or rising thyroglobulin antibodies (TgAb) levels with negative imaging; InR were defined by LT4-Tg <1 ng/mL or rhTSH-Tg <10 ng/mL or stable/declining TgAb levels with non-specific findings on imaging or faint radioiodine uptake in thyroid bed
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would prescribe DTE, whereas T4 + T3 combination therapy was reserved for specific indications (LT4 vs. DTE + T4 + T3; p < 0.01). Ninety-nine per cent of physicians appear to have a major influence on the thyroid management of their patients, since in
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thyroid nodules are benign, and 5–15% of them are thyroid malignancies. Fine-needle aspiration biopsy (FNAB) is a reliable, minimally invasive diagnostic method with high sensitivity and specificity in the evaluation of thyroid nodules [ 2 , 4 - 7
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words [ 9 , 22 - 24 ]. We hypothesized that a milder phenotype correlates with decreased protein stability rather than a T 3 -specific transport defect [ 19 , 20 ]. Decreased protein stability would lead to a diminished number of functional MCT8
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Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of China
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Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of China
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: identification of genes regulated by triiodothyronine in specific cell types . Cerebral Cortex 2017 27 706 – 717 . ( https://doi.org/10.1093/cercor/bhv273 ) 41 Salazar P Cisternas P Martinez M Inestrosa NC . Hypothyroidism and cognitive disorders
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eCRF included a range of filters and logical controls to reduce errors, and an authorized Clinical Research Associate helped data entering at various sites. Clinical endpoints of interest included OS and disease-specific survival (DSS), which were