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Xian Qiu Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Lin Cheng Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Ri Sa Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Department of Nuclear Medicine, The First Hospital of Jilin University, Changchun, China

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Hao Fu Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Department of Nuclear Medicine & Minnan PET Center, The First Affiliated Hospital of Xiamen University, Xiamen, China

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Yuchen Jin Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

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Libo Chen Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Introduction Thyroid cancer is responsible for 586,000 cases worldwide, ranking the ninth place for incidence in 2020, with differentiated thyroid cancer (DTC) accounting for over 90% ( 1 ). For DTC at an early stage, the optimal prognosis is

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Claudia Matta-Coelho Serviço de Endocrinologia, Hospital de Braga, Braga, Portugal
Center for Health Technology and Services Research (CINTESIS), Porto, Portugal

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Joana Simões-Pereira Serviço de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

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Helena Vilar Serviço de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Serviço de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

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Introduction The incidence of thyroid cancer has increased in the last few decades, with an average estimated incidence in 2012 of 20.0 cases per 100,000 in women and 6.3 cases per 100,000 in men [ 1 ]. Thyroid cancer is now the most common

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Kirsten E. Stewart Department of Head and Neck Surgery, St John’s Hospital at Howden, Livingston, United Kingdom

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Mark W.J. Strachan Metabolic Unit, Western General Hospital, Edinburgh, United Kingdom

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Devraj Srinivasan Department of Oncology, Western General Hospital, Edinburgh, United Kingdom

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Morna MacNeill Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

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Lucy Wall Department of Oncology, Western General Hospital, Edinburgh, United Kingdom

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Iain J. Nixon Department of Head and Neck Surgery, St John’s Hospital at Howden, Livingston, United Kingdom

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thyroid cancer (DTC) is increasing in incidence, with the most marked increase seen in small volume, low-risk lesions [ 1 ]. However, an increase in more advanced disease has also been reported [ 2 , 3 ]. The majority of patients present with disease

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Nandhini Lakshmana Perumal Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

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Jayakumar Selvi Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

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Kalyani Sridharan Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

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Jayaprakash Sahoo Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

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Sadishkumar Kamalanathan Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

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Introduction Graves’ disease (GD) is one of the most commonly encountered disorders in clinical practice with an annual incidence of 20–50 cases per 100,000 persons [ 1 ]. Thyroid hormones (THs) play a key role in intermediate metabolism, and

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Lars Folkestad Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Frans Brandt Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark

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Thomas Brix Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Marianne Vogsen Department of Oncology, Odense University Hospital, Odense, Denmark

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Lars Bastholt Department of Oncology, Odense University Hospital, Odense, Denmark

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Peter Grupe Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark

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Jeanette  Krogh Petersen Department of Clinical Pathology, Odense University Hospital, Odense, Denmark

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark

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:661–666. 10.1001/archinte.160.5.661 10724051 5 Wiersinga WM: Smoking and thyroid. Clin Endocrinol (Oxf) 2013; 79:145–151. 10.1111/cen.12222 23581474 6 Laurberg P, Pedersen KM, Vestergaard H, Sigurdsson G: High incidence of multinodular toxic

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Eyun Song Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Jonghwa Ahn Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Hye-Seon Oh Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Min Ji Jeon Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Gu Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Bae Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Young Kee Shong Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Tae Yong Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Introduction The incidence of body weight change (BWC) in patients with overt thyroid dysfunction exceeds 50%, representing one of the most common symptoms [ 1 , 2 ]. Overt hyperthyroidism (OHyper) is frequently associated with weight loss

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Bernard Goichot Department of Internal Medicine, Endocrinology and Nutrition, Hôpitaux Universitaires de Strasbourg
FMTS, Faculté de Médecine, Université de Strasbourg, Strasbourg

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Stéphane Bouée CEMKA, Bourg La Reine

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Claire Castello-Bridoux Medical Affairs Department, Merck Serono, Lyon

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Philippe Caron Department of Endocrinology, Metabolic Diseases and Nutrition, Pôle Cardio-Vasculaire et Métabolique, CHU Larrey
Inserm U1037, Université Paul Sabatier, Toulouse, France

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confirm the potential gain in terms of rapidity of achieving euthyroidism, the reduction in the number of laboratory monitoring thyroid tests, and the real incidence of hematological and hepatic adverse effects. In conclusion, our study is the first

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C. Daumerie Departments of Endocrinology, Université catholique de Louvain, University Hospital St-Luc, Brussels, Belgium

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A. Boschi Departments of Ophthalmology, Université catholique de Louvain, University Hospital St-Luc, Brussels, Belgium

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P. Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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, 9 , 10 ]. Several studies have demonstrated an increased incidence of nodules and of thyroid cancer (particularly well-differentiated carcinomas) in patients with Graves’ disease (GD), with reported cancer rates of 1–9% [ 11 , 12 ]. The coexistence

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Luigino Dal Maso Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Daniela Pierannunzio National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy

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Silvia Francisci National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy

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Angela De Paoli Epidemiological Department, Azienda Zero, Padova, Italy

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Federica Toffolutti Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Salvatore Vaccarella Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France

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Silvia Franceschi Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Ugo Fedeli Epidemiological Department, Azienda Zero, Padova, Italy

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of the DEPTH Working Group
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of the DEPTH Working Group

in absolute numbers, from 5220 RAI treatments in 2016 to 4219 in 2018 (Supplementary Table 1). Supplementary Table 2 and Supplementary Fig. 1 show incidence rates of RAI after TT per 100,000 women and men in Italy, overall and by age, all descreasing

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Marta Amaro da Silveira Duval Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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André Borsatto Zanella Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana Patrícia Cristo Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Carlo Sasso Faccin Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Marcia Silva Graudenz Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana Luiza Maia Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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, responsible for more than 80% of the cases [ 2 ]. While there is a consensus that the increasing use of imaging examinations contributes to the rising detection of subclinical disease, there is also an increased incidence of DTC of all sizes, including larger

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