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Lars C. Moeller Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Yaw Appiagyei-Dankah Medical University of South Carolina, Charleston, S.C., USA

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Birgit Köhler Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Heike Biebermann Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Onno E. Janssen Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Dagmar Führer Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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propositus' mother is heterozygous for this mutation and his sister inherited the normal allele (fig. 1 b). His mother was euthyroid (TSH 1.86 mIU/l, 0.35-5.50; fT 4 1.0 ng/dl, 0.9-1.8), but her TT 4 was also below the reference range (3.0 µg/dl, 4

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000381093
Volume/Issue:
Volume 4: Issue 1_Suppl
Free access
Ringo Manta Department of Nuclear Medicine, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Charlotte Martin Department of Infectious Diseases, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Vinciane Muls Department of Gastroenterology and Endoscopy, CHU Saint-Pierre, University Libre de Bruxelles (ULB), Brussels, Belgium

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Kris G Poppe Department of Endocrinology, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Reference range Year 2020 Year 2021 March 23 April 7 April 9 June 22 August 5 December 7 February 2 March 18 a April 12 April 14 April 27 Thyrotropin (mIU/L) 0.27–4.20 5.42 7.36 2.86 1.35 3.21 2/29 1

Article Type:
Case Report
Collections:
Hyperthyroidism and thyrotoxicosis
DOI:
https://doi.org/10.1530/ETJ-22-0049
Volume/Issue:
Volume 11: Issue 4
Open access
Diana Grove-Laugesen Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Sofie Malmstroem Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Eva Ebbehoj Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Anne Lene Riis Medical Department, Regional Hospital Horsens, Horsens, Denmark

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Torquil Watt Department of Internal Medicine, Gentofte and Herlev Hospital, Hellerup, Denmark

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Lars Rejnmark Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Klavs Würgler Hansen Medical Department, Silkeborg Regional Hospital, Silkeborg, Denmark

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media. Inclusion criteria of the patients were age between 18 and 80 years, a first-time diagnosis of GD, elevated level of thyrotropin receptor antibody, hyperthyroidism at first visit (TSH <reference range and free levels of triiodothyronine and

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000505873
Volume/Issue:
Volume 9: Issue 3
Free access
Sylvie Hiéronimus Departments of Endocrinology, Diabetology and Reproductive Medicine

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Patricia Ferrari Departments of Biochemistry, University Hospital of Nice

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Jocelyn Gal Department of Biostatistics, University of Nice

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Frédéric Berthier Department of Biostatistics, University of Nice

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Stéphane Azoulay Institute of Chemistry, UMR 6001, University of Nice-Sophia-Antipolis

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André Bongain Gynaecology and Obstetrics, University Hospital of Nice

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Patrick Fénichel Departments of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France

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Françoise Brucker-Davis Departments of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France

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-Cerba Laboratory). Reference ranges were established in our laboratory for fT4 and TSH during the first trimester of pregnancy (2.5 and 97.5 percentiles): fT4 11.47–19.23 pmol/l, and TSH 0.053–3.23 mUI/l. The other (nonpregnancy) reference ranges were provided by

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000342915
Volume/Issue:
Volume 1: Issue 4
Free access
Laura Fugazzola Department of Clinical Sciences and Community Health, University of Milan and Endocrine Unit, Fondazione IRCCS Ca' Granda, Milan, Italy

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in adults, without significant gender differences in the children population [ 18 ]. In adults, Ct values should be interpreted in the setting of sex-specific reference ranges, as suggested by ATA guidelines [ 10 ], though most centers to date have a

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000346020
Volume/Issue:
Volume 2: Issue 1
Free access
Nadine Johnson Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Vikash Chatrani Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Anna-Kay Taylor-Christmas Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Eric Choo-Kang Departments of Chemical Pathology, University of the West Indies, Kingston, Jamaica

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Monica Smikle Departments of Microbiology, University of the West Indies, Kingston, Jamaica

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Rosemarie Wright-Pascoe Departments of Medicine, University of the West Indies, Kingston, Jamaica

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Karen Phillips Departments of Medicine, University of the West Indies, Kingston, Jamaica

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Marvin Reid Tropical Metabolism Research Institute, University of the West Indies, Kingston, Jamaica

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R3. For TPOAb-positive subjects' rates, reference values R1, R2 and R3 were 15% (3/20), 5% (1/20) and 20% (4/20), respectively. Table 1 Prevalence of thyroid hormone deficiency using three reference ranges Rates of positive TPOAb

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000367654
Volume/Issue:
Volume 3: Issue 4
Free access
Emna Jelloul Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Georgiana Sitoris Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Flora Veltri Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Pierre Kleynen Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Serge Rozenberg Departement of Gynecology and Obstetrics, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Kris G Poppe Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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institutional trimester-specific limits for serum TSH and FT4 ( 10 ). Our reference range for serum TSH (2.5–97.5th percentile) during the period 11 (9–14) weeks was 0.06–3.74 mIU/L, and 10.29–18.02 pmol/L for serum FT4 ( 10 ). Thyroid autoimmunity (TAI) was

Article Type:
Research Article
Collections:
Thyroid and reproduction
DOI:
https://doi.org/10.1530/ETJ-23-0112
Volume/Issue:
Volume 12: Issue 6
Open access
Jacqueline Jonklaas Division of Endocrinology, Georgetown University, Washington, District of Columbia, USA

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Antonio C. Bianco Section of Adult and Pediatric Endocrinology and Metabolism, University of Chicago, Chicago, Illinois, USA

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Anne R. Cappola Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Francesco S. Celi Division of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University, Richmond, Virginia, USA

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Eric Fliers Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, Amsterdam, The Netherlands

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Heike Heuer Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany

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Elizabeth A. McAninch Division of Endocrinology, Rush University, Chicago, Illinois, USA

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Lars C. Moeller Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany

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Birte Nygaard Center for Endocrinology and Metabolism, Department of Internal Medicine, Herlev and Gentofte Hospitals, Herlev, Denmark

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Anna M. Sawka Division of Endocrinology, University Health Network and University of Toronto, Toronto, Ontario, Canada

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Torquil Watt Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Colin M. Dayan Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom

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function in healthy individuals with an intact HPT axis. Specifically, the assumption has been that a TSH in the reference range is the most important and sensitive parameter in assessing for euthyroidism, and the measurement of TH levels is secondary and

Article Type:
Guideline
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1159/000512970
Volume/Issue:
Volume 10: Issue 1
Free access
Laura Croce Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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Fausta Beneventi Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Federica Ripepi Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy

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Irene De Maggio Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Alberto Malovini Istituti Clinici Scientifici Maugeri IRCCS, Laboratory of Informatics and Systems Engineering for Clinical Research, Pavia (PV), Italy

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Camilla Bellingeri Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Francesca Coperchini Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy

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Marsida Teliti Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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Mario Rotondi Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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Arsenio Spinillo Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Flavia Magri Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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using a third generation immunoassay Immunolite 2000® Systems Analyzer (Siemens Healthcare) employing monoclonal antibodies. In the absence of a trimester-specific reference range, we chose the reference range for TSH in the non-pregnant adult population

Article Type:
Research Article
Collections:
Thyroid and reproduction
DOI:
https://doi.org/10.1530/ETJ-23-0213
Volume/Issue:
Volume 13: Issue 2
Open access
Fabio Maino Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Cristina Dalmiglio Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Nicoletta Benenati Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Michele Campanile Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Tania Pilli Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Raffaella Forleo Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Lucia Brilli Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Cristina Ciuoli Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Silvia Cantara Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Marco Capezzone Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Alessandra Cartocci Department of Medical Biotechnologies, University of Siena, Siena, Italy

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Furio Pacini Humanitas Clinical Institute, Humanitas University, Rozzano, Italy

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Maria Grazia Castagna Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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, Schlienger JL , Sapin R , . Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking . Eur J Endocrinol . 2007 Dec ; 157 ( 6 ): 749 – 55 . 14 Castagna MG , Fugazzola L

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000511080
Volume/Issue:
Volume 10: Issue 4
Free access