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Introduction Graves’ disease (GD) is the most prevalent organ-specific autoimmune disorder and the primary cause of hyperthyroidism. GD is a well-characterized autoimmune thyroid disease with a large number of known susceptibility genes [ 1
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, PDGFRA, PIK3CA, RAF1, RET, ROS1, SMO. Library amplification with bridge-PCR and high rate sequencing were performed on an lllumina (MiSeq or MiniSeq) platform. The bioinformatic analysis (detection sensitivity >99%) was made using the Sequence Pilot
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University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital, Basel, Switzerland
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Division of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland
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this study was to investigate sex-specific variations in relevant patient-oriented clinical outcomes following thyroidectomy using a large population-based cohort. Material and Methods Study Design, Data Sources, and Participants In this
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[ 2 ], followed by Jack Robbins, Jacques Blondeau and several others. The unspecific association of radiolabeled TH with cells always represented an issue, but several laboratories showed saturable and stereo-specific uptake indicative of plasma
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remove the tumor completely with resection, and the incidence of recurrent laryngeal injury is high. External irradiation is not routinely used to treat thyroid cancer, as it is difficult to cure the tumor because of the low radiation sensitivity and dose
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Santa Casa de São Paulo, São Paulo, Brazil
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Fleury Medicina e Saúde, São Paulo, Brazil
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the FNA procedure, such as sensitivity, specificity, positive predictive value (VPP) and negative predictive value (VPN), were calculated using the formulae of Galen and Gambino [ 22 ]. True-negative samples were considered to be nodules with both a
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have high cause-specific survival rates that, on average, exceed 95% [ 2 ]. Yet, there is subset of differentiated thyroid cancers (DTCs) that do not respond to traditional therapies and have worse outcomes. Furthermore, medullary thyroid cancers (MTCs
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Departments of Biopathology, Centre François Baclesse, Caen, France
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cytology [ 3 , 4 ]. The sensitivity of this molecular approach is still limited, however, and further molecular markers are probably needed to improve its usefulness in routine [ 5 ]. In more than 70% of papillary thyroid carcinomas (PTC), activating
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]. 131 I whole-body imaging with TSH stimulation can localize sites of recurrence. The sensitivity of 131 I scanning and Tg measurement is limited by a small, relative amount of thyroid tissue present in patients treated by thyroidectomy and the
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are ovoid, but a round shape (L/S ratio below 2) can be seen in up to 36% [ 24 , 25 , 26 , 27 , 29 ]. Abnormal LNs: sensitivity and specificity of abnormal US and Doppler-US patterns are summarized in table 2 [ 25 , 26 , 27 , 29 , 30 ]. Table