Kaoru Kobayashi
Kaoru Kobayashi
Kuma Hospital, Kobe, Japan
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Hisashi Ota
Hisashi Ota
Kuma Hospital, Kobe, Japan
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Mitsuyoshi Hirokawa
Mitsuyoshi Hirokawa
Kuma Hospital, Kobe, Japan
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Tomonori Yabuta
Tomonori Yabuta
Kuma Hospital, Kobe, Japan
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Mitsuhiro Fukushima
Mitsuhiro Fukushima
Kuma Hospital, Kobe, Japan
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Hiroo Masuoka
Hiroo Masuoka
Kuma Hospital, Kobe, Japan
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Takuya Higashiyama
Takuya Higashiyama
Kuma Hospital, Kobe, Japan
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Minoru Kihara
Minoru Kihara
Kuma Hospital, Kobe, Japan
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Yasuhiro Ito
Yasuhiro Ito
Kuma Hospital, Kobe, Japan
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Akihiro Miya
Akihiro Miya
Kuma Hospital, Kobe, Japan
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Akira Miyauchi
Akira Miyauchi
Kuma Hospital, Kobe, Japan
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existed within each nodule separately or individually on Doppler ultrasonography (Fig. 1 a). Fine-needle aspiration cytology revealed a “follicular neoplasm.” A right lobectomy of the thyroid was performed, and the whole nodule was diagnosed as a
Yulia P. Sych
Yulia P. Sych
Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
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Valentin V. Fadeev
Valentin V. Fadeev
Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
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Elena P. Fisenko
Elena P. Fisenko
Laboratory of Ultrasound Diagnostics, Federal State Research Institution “B.V. Petrovsky National Research Centre of Surgery”, Moscow, Russian Federation
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Marina Kalashnikova
Marina Kalashnikova
Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
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images in B-mode and Doppler regimen were recorded and stored at first visualization before the application of fine-needle aspiration biopsy (FNAB) using different ultrasound machines: Aixplorer (France), Voluson E8 (GE, USA), Hitachi (Japan), or Aloka
Luigino Dal Maso
Luigino Dal Maso
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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Daniela Pierannunzio
Daniela Pierannunzio
National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy
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Silvia Francisci
Silvia Francisci
National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy
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Angela De Paoli
Angela De Paoli
Epidemiological Department, Azienda Zero, Padova, Italy
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Federica Toffolutti
Federica Toffolutti
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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Salvatore Vaccarella
Salvatore Vaccarella
Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France
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Silvia Franceschi
Silvia Franceschi
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Ugo Fedeli
Ugo Fedeli
Epidemiological Department, Azienda Zero, Padova, Italy
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of the DEPTH Working Group
of the DEPTH Working Group
of the DEPTH Working Group
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diagnostic pressure, namely fine-needle aspiration biopsies of thyroid nodules, were reported at the population level in some Italian areas after 2014 ( 24 ). Meanwhile, the growth in thyroid cancer surgery previously registered in Italy leveled off after
Eduardo Crespo Vallejo
Eduardo Crespo Vallejo
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Antonio Hermosin
Antonio Hermosin
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Manuel Gargallo
Manuel Gargallo
Endocrinology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Álvaro Villalba
Álvaro Villalba
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Eduardo Daguer
Eduardo Daguer
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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José Flores
José Flores
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Javier Periañez
Javier Periañez
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Joaquim Amorín
Joaquim Amorín
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Ernesto Santos
Ernesto Santos
Interventional Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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to March 2021 in our institution. All patients presented ultrasound (US) findings suggestive of BTN and had benign cytologic confirmation by two consecutive US‐guided fine‐needle aspiration cytology (FNAC) procedures. The patients were selected
L.A. Jonker
L.A. Jonker
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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C.A. Lebbink
C.A. Lebbink
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M.C.J. Jongmans
M.C.J. Jongmans
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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R.A.J. Nievelstein
R.A.J. Nievelstein
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Pediatric Radiology and Nuclear Medicine, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Radiology and Nuclear Medicine, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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J.H.M. Merks
J.H.M. Merks
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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E.J.M. Nieveen van Dijkum
E.J.M. Nieveen van Dijkum
Department of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands
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T.P. Links
T.P. Links
Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
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N. Hoogerbrugge
N. Hoogerbrugge
Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands
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A.S.P. van Trotsenburg
A.S.P. van Trotsenburg
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands
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H.M. van Santen
H.M. van Santen
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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weeks, one node was removed (surgical approach chosen over fine-needle aspiration cytology on surgeon’s preference) for pathological examination, which demonstrated a reactive lymph node without signs of malignancy. Despite this reassuring result, later
Mohamed Abdouh
Mohamed Abdouh
Cancer Research Program, McGill University Health Centre-Research Institute, Montreal, Québec, Canada
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Roger Tabah
Roger Tabah
Department of Surgery and Department of Oncology, McGill University Health Centre, Montreal, Québec, Canada
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Vincenzo Arena
Vincenzo Arena
Department of Obstetrics and Gynecology, Santo Bambino Hospital, Catania, Italy
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Manuel Arena
Manuel Arena
Fondazione Istituto G. Giglio Cefalù, Pisciotto, Italy
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Zu-hua Gao
Zu-hua Gao
Department of Pathology, McGill University Health Centre-Research Institute, Montreal, Québec, Canada
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Aurelio Lorico
Aurelio Lorico
College of Medicine, Touro University Nevada, Henderson, Nevada, USA
Istituto Oncologico del Mediterraneo, Viagrande, Italy
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Istituto Oncologico del Mediterraneo, Viagrande, Italy
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Goffredo Orazio Arena
Goffredo Orazio Arena
Fondazione Istituto G. Giglio Cefalù, Pisciotto, Italy
Istituto Oncologico del Mediterraneo, Viagrande, Italy
Department of Surgery, McGill University, St. Mary Hospital, Montreal, Québec, Canada
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Istituto Oncologico del Mediterraneo, Viagrande, Italy
Department of Surgery, McGill University, St. Mary Hospital, Montreal, Québec, Canada
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difficulty in distinguishing benign from malignant tumors. Investigations such as fine needle aspiration cytology and MRI scans provide some useful information, but most cases will require surgical excision as a means of coming to a definitive diagnosis
Emilio Fiore
Emilio Fiore
Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy
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Francesco Latrofa
Francesco Latrofa
Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy
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Paolo Vitti
Paolo Vitti
Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy
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submitted to fine-needle aspiration of thyroid nodules and to thyroid surgery [ 51 ]. We showed that the prevalence of TAb was similar in patients with benign nodules as compared to patients with malignant nodules at cytology (38.7 vs. 35.6%, respectively
Tommaso Piticchio
Tommaso Piticchio
Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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Gilles Russ
Gilles Russ
Department of Thyroid and Endocrine Tumor Diseases, La Pitie-Salpetriere Hospital, 83 Bd de l’Hopital, Paris, France
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Maija Radzina
Maija Radzina
Riga Stradins University, Radiology Research Laboratory, Riga, Latvia
University of Latvia, Faculty of Medicine, Riga, Latvia
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University of Latvia, Faculty of Medicine, Riga, Latvia
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Francesco Frasca
Francesco Frasca
Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy
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Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Pierpaolo Trimboli
Pierpaolo Trimboli
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland
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Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland
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risks; (3) assess TNs according to risk classes; and (4) select TNs for fine needle aspiration cytology (FNAC) ( 7 ). The advent of TIRADSs has resulted in a substantial increase in published papers, thereby strengthening the evidence in the field. In
Carles Zafon
Carles Zafon
Department of Endocrinology, Spain
Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain
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Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain
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Juan Antonio Baena
Juan Antonio Baena
Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain
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Josep Castellví
Josep Castellví
Department of Pathology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Spain
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Gabriel Obiols
Gabriel Obiols
Department of Endocrinology, Spain
Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain
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Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain
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Oscar Gonzalez
Oscar Gonzalez
Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain
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José Manuel Fort
José Manuel Fort
Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain
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Ramon Vilallonga
Ramon Vilallonga
Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain
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Enric Caubet
Enric Caubet
Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain
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Manuel Armengol
Manuel Armengol
Endocrine, Bariatric and Metabolic Unit, Department of General Surgery, Spain
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Jordi Mesa
Jordi Mesa
Department of Endocrinology, Spain
Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain
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Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona, Spain
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included patients had a solitary nodule or a multinodular goiter detected by clinical examination, US, or both. Preoperatively, an US confirmed nodular thyroid disease in all cases. A fine-needle aspiration biopsy (FNAB) was performed for thyroid nodules >1
Pedro Weslley Souza Rosario
Pedro Weslley Souza Rosario
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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Gabriela Franco Mourão
Gabriela Franco Mourão
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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Pedro Henrique Lopes Oliveira
Pedro Henrique Lopes Oliveira
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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Tulio Henrique Silva
Tulio Henrique Silva
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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(hypoechoic with irregular margins or microcalcifications/rim calcifications with a small extrusive soft tissue component or taller than wide shape [ 5 , 6 ]) were, until recently, submitted to US-guided fine-needle aspiration. Cases with cytology suspicious
