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  • iodine concentration level x
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Pedro Weslley Souza Rosario Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Gabriela Franco Mourão Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Maria Regina Calsolari Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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thyroid hormone concentrations within the reference range [ 1 , 2 , 5 ]. In a recent editorial, Professor Wiersinga proposed to add the presence of thyroid disease for the diagnosis of SCH [ 5 ]. This new definition prevents the erroneous treatment of

Article Type:
Letter
DOI:
https://doi.org/10.1159/000441416
Volume/Issue:
Volume 4: Issue 4
Free access
Antonio C. Bianco Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Fla., USA

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Sabina Casula Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Fla., USA

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Hypothyroidism affects about 3.7% of the general population in the United States [ 1 ], reaching levels of up to 8% in areas with high prevalence of iodine deficiency [ 2 ]. At first sight, treatment for hypothyroidism, regardless of its

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000339447
Volume/Issue:
Volume 1: Issue 2
Free access
Mafalda Marcelino Department of Endocrinology, Armed Forces University Hospital, Lisbon, Portugal
Department of Endocrinology, Portuguese Institute of Oncology, Lisbon, Portugal

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Pedro Marques Department of Endocrinology, Portuguese Institute of Oncology, Lisbon, Portugal

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Luis Lopes Department of Endocrinology, Armed Forces University Hospital, Lisbon, Portugal

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Valeriano Leite Department of Endocrinology, Portuguese Institute of Oncology, Lisbon, Portugal

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João Jácome de Castro Department of Endocrinology, Armed Forces University Hospital, Lisbon, Portugal

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seen as a protective condition for thyroid cancer, and a relationship between low serum TSH levels and a lower incidence of papillary carcinoma has been suggested [ 6 , 7 ]. However, a recent meta-analysis could not confirm this association [ 8

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000367893
Volume/Issue:
Volume 3: Issue 4
Free access
Eveline Bruinstroop Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands

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Anne H van der Spek Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands

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Anita Boelen Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands

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predominant. The intracellular concentration of thyroid hormone is regulated by specific enzymes, so-called deiodinases ( 2 ). Deiodinases are able to remove an iodine atom from the outer or inner ring of the tyrosyl backbone. There are three types of

Article Type:
Review Article
Collections:
Thyroid hormone action
DOI:
https://doi.org/10.1530/ETJ-22-0211
Volume/Issue:
Volume 12: Issue 3
Open access
Lars Folkestad Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Frans Brandt Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark

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Thomas Brix Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Marianne Vogsen Department of Oncology, Odense University Hospital, Odense, Denmark

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Lars Bastholt Department of Oncology, Odense University Hospital, Odense, Denmark

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Peter Grupe Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark

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Jeanette  Krogh Petersen Department of Clinical Pathology, Odense University Hospital, Odense, Denmark

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark

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. After the first dose of RAI, the T 3 and T 4 levels decreased to normal, but TSH remaining suppressed. After the fourth dose of RAI, TSH concentration became measurable. During the fall of 2014 the patient was taken off PTU, with TSH, T 3 , and T 4

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000479061
Volume/Issue:
Volume 6: Issue 5
Free access
Eddy Rijntjes Institut für Experimentelle Endokrinologie, Charité-Universtätsmedizin Berlin, Berlin, Germany

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Philip Moritz Scholz Institut für Experimentelle Endokrinologie, Charité-Universtätsmedizin Berlin, Berlin, Germany

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Govindasamy Mugesh Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, India

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité-Universtätsmedizin Berlin, Berlin, Germany

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on the x-axis (fig. 1 b, non-competitive). On the other hand, concentrations higher than or around the IC 50 seem to follow a competitive type of interaction with varying levels of the cofactor DTT (fig. 1 a, b). The two other compounds tested on

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000355288
Volume/Issue:
Volume 2: Issue 4
Free access
Kris Poppe Endocrine Unit, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Peter Bisschop Department of Endocrinology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Laura Fugazzola Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, and Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Gesthimani Minziori Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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David Unuane Department of Internal Medicine, Endocrine Unit, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium

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Andrea Weghofer Department of Gynecological Endocrinology & Reproductive Medicine, Medical University of Vienna, Vienna, Austria

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(er) TSH concentrations [ 22 ]. Although a higher prevalence of elevated TgAb levels has been reported in women with subfertility, their significance remains uncertain [ 28 ]. Research examining TAI prevalence in subfertile women or any association between

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000512790
Volume/Issue:
Volume 9: Issue 6
Free access
Selwan Khamisi Department of Endocrinology and Diabetes, Uppsala University, Uppsala, Sweden

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Peter Lindgren Women's and Children's Health, University Hospital, Uppsala University, Uppsala, Sweden

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F. Anders Karlsson Department of Endocrinology and Diabetes, Uppsala University, Uppsala, Sweden

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low iodine availability, genetic defects in hormonogenesis, inhibition of hormone synthesis by thyrostatic drugs (the most common explanation of fetal goiters today) and also, as reported in historical cases, when hormone synthesis is inhibited by

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000357973
Volume/Issue:
Volume 3: Issue 1
Free access
Simon H.S. Pearce Institute of Genetic Medicine, Newcastle University
Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Georg Brabant Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

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Leonidas H. Duntas Endocrine Unit, Evgenidion Hospital, University of Athens, Athens, Greece

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Fabio Monzani Department of Clinical and Experimental Medicine, Università di Pisa, Pisa, Italy

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Robin P. Peeters Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Salman Razvi Institute of Genetic Medicine, Newcastle University
Queen Elizabeth Hospital, Gateshead, UK

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Jean-Louis Wemeau Clinique Endocrinologique Marc Linquette, CHU, Lille, France

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Introduction Subclinical hypothyroidism (SCH) is defined as a state of increased serum thyroid-stimulating hormone (TSH) levels, with circulating thyroxine (T 4 ) and tri-iodothyronine (T 3 ) concentrations within the population reference

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000356507
Volume/Issue:
Volume 2: Issue 4
Free access
Bruno Bouça Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Ana Cláudia Martins Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Paula Bogalho Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Lídia Sousa Cardiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Tiago Bilhim Interventional Radiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Filipe Veloso Gomes Interventional Radiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Élia Coimbra Interventional Radiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Ana Agapito Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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José Silva-Nunes Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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very effective for both supra- and ventricular tachyarrhythmia, is hemodynamically well tolerated by patients with impaired inotropic function and/or pre-existent hypotension, and also prevents sudden cardiac death ( 2 ). Due to its high iodine

Article Type:
Case Report
Collections:
Hyperthyroidism and thyrotoxicosis
DOI:
https://doi.org/10.1530/ETJ-21-0007
Volume/Issue:
Volume 11: Issue 1
Open access