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Junyu Tong Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Maomei Ruan Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China

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Yuchen Jin Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Hao Fu Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Lin Cheng Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Qiong Luo Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China

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Zhiyan Liu Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Zhongwei Lv Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China

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Libo Chen Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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immunohistochemistry confirm the theory of a continuum from DTC to ATC through PDTC. However, no specific immunohistochemical marker has been established for the detection of PDTC yet ( 14 , 18 ). Majority of DTCs express high levels of thyroglobulin (Tg); however

Article Type:
Review Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-22-0021
Volume/Issue:
Volume 11: Issue 2
Open access
Joanna Szumska Department of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany

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Maria Qatato Department of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany

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Maren Rehders Department of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany

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Dagmar Führer Department of Endocrinology and Metabolism and Division of Laboratory Research, University of Duisburg-Essen, Essen, Germany

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Heike Biebermann Institut für Experimentelle Pädiatrische Endokrinologie, Berlin, Germany

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David K. Grandy Department of Physiology and Pharmacology, School of Medicine and the Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oreg., USA

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Klaudia Brix Department of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany

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spherical structures in which polarized thyrocytes face the extracellular follicle lumen with their apical plasma membrane domain. The prohormone thyroglobulin is synthesized by thyrocytes and, upon secretion and iodination, is stored within the lumen. TSH

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000434717
Volume/Issue:
Volume 4: Issue 1_Suppl
Free access
Markus Eszlinger Department of Oncology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada, and Institute of Pathology, University Hospital Halle, Halle, Germany

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Alexandra Stephenson Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada

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Shideh Mirhadi Program in Cell Biology, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada

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Konrad Patyra Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland

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Michael F Moran Program in Cell Biology, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada

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Moosa Khalil Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Jukka Kero Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
Department of Pediatrics, Turku University Hospital, Turku, Finland

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Ralf Paschke Department of Oncology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada, and Institute of Pathology, University Hospital Halle, Halle, Germany
Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada

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by TSHR and sex. (D) Relative intensities of thyroglobulin phosphosites To identify these baseline sex differences, the phosphorylation patterns of phosphopeptides of WT males and females were compared to one another. Significantly different

Article Type:
Research Article
Collections:
Thyroid cancer - basic and translational
DOI:
https://doi.org/10.1530/ETJ-23-0049
Volume/Issue:
Volume 12: Issue 6
Open access
Cengiz Kara Department of Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey
Department of Pediatric Endocrinology, Faculty of Medicine, Istinye University, Istanbul, Turkey

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Jamala Mammadova Pediatric Endocrinology Unit, Altinbas University Medicalpark Bahçelievler Hospital, Istanbul, Turkey

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Ümmet Abur Department of Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey
Department of Medical Genetics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

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Cagri Gumuskaptan Department of Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey
Department of Medical Genetics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

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Elif İzci Güllü Department of Pediatric Endocrinology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

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Ayhan Dağdemir Department of Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey

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Murat Aydın Department of Pediatric Endocrinology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

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.7–100) 100 (40.4–100) 0.12 Free T4 (RR: 0.89–2.2 ng/dL) c 0.62 ± 0.33 0.81 ± 0.39 0.04 Free T3 (RR: 1.95–6.0 pg/mL) c 2.97 ± 1.29 4.02 ± 2.06 0.12 Thyroglobulin (RR: 20–228 ng/mL) 5.0 (1.3–17.8) 300 (142–300) <0

Article Type:
Research Article
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1530/ETJ-22-0212
Volume/Issue:
Volume 12: Issue 3
Open access
Mikael Nilsson Sahlgrenska Cancer Center, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden

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Dillwyn Williams Department of Public Health, University of Cambridge, Cambridge, UK

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embryonic origin but strongly suggests a kinship of thyroid follicular and C cells with roots in early development from pharyngeal endoderm. In the embryonic thyroid, the calcitonin gene is switched on in C cells concomitantly with that of thyroglobulin in

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000447333
Volume/Issue:
Volume 5: Issue 2
Free access
Furio Pacini Section of Endocrinology, University of Siena, Siena, Italy

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Dagmar Fuhrer Department of Endocrinology, Diabetes and Metabolism, West German Cancer Centre (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Rossella Elisei Section of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Daria Handkiewicz-Junak Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland

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Sophie Leboulleux Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France

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Markus Luster Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany

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Martin Schlumberger Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France

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Johannes W Smit Radboud University Medical Center, Nijmegen, Netherlands

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thyroglobulin and RAI imaging). Within the context of thyroid cancer care, adjuvant therapies can be defined as I-131 therapy after surgical resection of all known primary tumor tissue and metastatic foci in an effort to destroy subclinical microscopic tumor

Article Type:
Other
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-21-0046
Volume/Issue:
Volume 11: Issue 1
Open access
Allan Carlé Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark

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Nils Knudsen Department of Endocrinology I, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark

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Torben Jørgensen Centre for Clinical Research and Prevention, Capital Region of Denmark, Copenhagen, Denmark
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Bettina Thuesen Centre for Clinical Research and Prevention, Capital Region of Denmark, Copenhagen, Denmark

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Jesper Karmisholt Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark

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Stine Linding Andersen Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Inge Bülow Pedersen Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark

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Characteristics Thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), and TRAb were measured after study end [ 20 , 23 ]. Subjects with antibody concentration above the functional sensitivity given by the manufacturer (TPOAb: > 30 kU/L, TgAb: > 20

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000494836
Volume/Issue:
Volume 8: Issue 2
Free access
Marco Capezzone Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Noemi Fralassi Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Chiara Secchi Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Silvia Cantara Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Lucia Brilli Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Tania Pilli Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Fabio Maino Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Raffaella Forleo Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Furio Pacini Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Gabriele Cevenini Department of Medical Biotechnologies, University of Siena, Siena, Italy

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Alessandra Cartocci Department of Medical Biotechnologies, University of Siena, Siena, Italy

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Maria Grazia Castagna Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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, respectively, an excellent response if there was no clinical, biochemical or structural evidence of disease; a biochemical incomplete response if there were abnormal thyroglobulin or rising anti-thyroglobulin antibody levels in the absence of localizable

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000506955
Volume/Issue:
Volume 9: Issue 4
Free access
Evangelos Karvounis Department of Endocrine Surgery Center of Excellence, Euroclinic Hospital, Athens, Greece

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Ioannis Kappas Department of Endocrine Surgery Center of Excellence, Euroclinic Hospital, Athens, Greece

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Anna Angelousi First Department of Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece

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Georgios-Marios Makris Department of Gynecology, Euroclinic Hospital, Athens, Greece

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Eva Kassi First Department of Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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the growth of a pathological clone which could in turn lead to a progressive replacement of the normal lymphoid cell line, giving rise to MALT lymphoma. In 2009, Munemasa et al. [ 23 ] investigated the B-cell response to thyroglobulin

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000502204
Volume/Issue:
Volume 9: Issue 1
Free access
Mohammad-Reza Mahmoudian-sani Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Department of Genetics and Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

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Ameneh Mehri-Ghahfarrokhi Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

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Majid Asadi-Samani Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran

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Gholam-Reza Mobini Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

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conditions such as follicular adenomas, cysts, and goiter. A total of 75% of patients who undergo hemithyroidectomy for the benign disease do not need to do so. In addition, the measurement of thyroglobulin as a noninvasive method cannot be applied to measure

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000468520
Volume/Issue:
Volume 6: Issue 4
Free access