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The 2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma ( 1 ) were developed by a task force comprising well-respected, expert clinicians with good representation of the
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Introduction Palpable goitre has a prevalence of 10-30% in middle-aged women in the Western world [ 1 , 2 , 3 , 4 , 5 ] and, with modern ultrasound, thyroid nodules have been found in 30-70% of the adult population [ 6 , 7 ]. This implies that
Center for Genomic Research, Italy
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considered a diagnostic marker of PTC [ 1 ]. The wide clinical use of ultrasound (US) [ 5 ] allows detecting an increasing number of nodules that often require fine needle aspiration biopsy (FNAB) for ruling out thyroid cancer [ 6 ]. As the diagnostic value
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(CT) scan of the neck. On CT, a left thyroid lobe nodule was identified with no other findings in the neck. Subsequent ultrasonography demonstrated a multinodular goiter with a dominant nodule at the inferior pole of the left lobe measuring 26 × 27
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subgroup consisted of 516 patients of whom thyroid weights were known in 416 patients (81%). Patients with surgery for benign nodule/goiter volume-related complaints are expected to be represented in this subgroup. Therefore, thyroid weight in this patient
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Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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hospital visit. Palpation revealed a painless, firm, 2.5 × 2.0-cm nodule on the right side of her neck. Thyroid function tests revealed a euthyroid status. Anti-thyroglobulin and anti-thyroperoxidase antibodies levels were high (1,490 IU/mL [reference range
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showing displaced benign thyroid tissue within the muscular fibers. Hematoxylin–eosin–safran, 100×. (C) CT scan, arrows show the subcutaneous nodules, the invasion of the sternocleidomastoid muscle, and the right thyroid compartment. We performed
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with PTC than in those with adenomatous goiter or follicular adenoma. Ott et al. [ 40 , 41 ] reported a high incidence of thyroid carcinoma (32%) in 146 patients with HT and solitary cold nodules. However, other studies yielded conflicting results
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investigate the cervical nodule, which was a hard, but not adherent, supraclavicular node 5 cm in diameter. There was no evidence of compressive signs such as dysphagia or dyspnea. Thyroid gland palpation revealed a soft nodule of 1.5 cm in the left lobe. The
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diagnostic pressure, namely fine-needle aspiration biopsies of thyroid nodules, were reported at the population level in some Italian areas after 2014 ( 24 ). Meanwhile, the growth in thyroid cancer surgery previously registered in Italy leveled off after