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Shi Hui Junice Wong Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore

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the draining cervical lymph nodes. Given the paucity of data regarding this phenomenon, other more common concomitant pathologies giving rise to lymphadenitis (such as malignancies and infections) need to be excluded. The patient in this report had

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Lars Folkestad Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Frans Brandt Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark

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Thomas Brix Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Marianne Vogsen Department of Oncology, Odense University Hospital, Odense, Denmark

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Lars Bastholt Department of Oncology, Odense University Hospital, Odense, Denmark

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Peter Grupe Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark

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Jeanette  Krogh Petersen Department of Clinical Pathology, Odense University Hospital, Odense, Denmark

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark

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of antibodies binding to and stimulating the thyrotropin receptor (TRAB), resulting in hyperthyroidism [ 1 ]. GD is common, with a lifetime risk of around 5% [ 2 ]. The etiology of GD is in­adequately understood, but is generally thought to be the

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Sepehr Torabinejad Department of Clinical Medicine and Surgery, University of Naples ’Federico II’, Naples, Italy

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Caterina Miro Department of Clinical Medicine and Surgery, University of Naples ’Federico II’, Naples, Italy

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Biagio Barone Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II

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Ciro Imbimbo Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II

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Felice Crocetto Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II

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Monica Dentice Department of Clinical Medicine and Surgery, University of Naples ’Federico II’, Naples, Italy
CEINGE – Biotecnologie Avanzate Scarl, Naples, Italy

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). Although population-based studies suggest that subclinical and clinical hyperthyroidism increase the risk of solid malignancies, there are still controversies on the effects of hypo- and hyperthyroidism in PCa, partially due to the highly spatiotemporally

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Ian D Hay Department of Medicine 1, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Suneetha Kaggal Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Geoffrey B Thompson Department of Surgery, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Introduction Adults with low-risk ( 1 ) papillary thyroid carcinoma (PTC) represent the commonest endocrine malignancy ( 2 ). In 2017, Pontius and colleagues ( 3 ) demonstrated, in a study of 244,040 PTC patients managed in USA during 2004

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Dorothée Bouron-Dal Soglio Department of Pathology, CHU Sainte-Justine, Montreal, Québec, Canada

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Leanne de Kock The Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Québec, Canada
Department of Human Genetics, McGill University, Montreal, Québec, Canada

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Richard Gauci Nuclear Medicine, Sir Charles Gairdner Hospital, Nedlands, Washington, Australia

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Nelly Sabbaghian The Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Québec, Canada

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Elizabeth Thomas Nuclear Medicine, Sir Charles Gairdner Hospital, Nedlands, Washington, Australia
Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Subiaco, Washington, Australia

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Helen C. Atkinson Faculty of Health and Medical Sciences, School of Medicine, The University of Western Australia, Crawley, Washington, Australia

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Nicholas Pachter Faculty of Health and Medical Sciences, School of Medicine, The University of Western Australia, Crawley, Washington, Australia
King Edward Memorial Hospital, Perth, Washington, Australia

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Simon Ryan Department of General Surgery, Sir Charles Gairdner Hospital, Nedlands, Washington, Australia

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John P. Walsh Faculty of Health and Medical Sciences, School of Medicine, The University of Western Australia, Crawley, Washington, Australia
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Washington, Australia

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M. Priyanthi Kumarasinghe PathWest, QEII Medical Centre, Perth, Washington, Australia

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Karen Carpenter Department of Diagnostic Genomics, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, Washington, Australia

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Ayça Aydoğan Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey

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Colin J.R. Stewart King Edward Memorial Hospital, Perth, Washington, Australia

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William D. Foulkes The Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Québec, Canada
Department of Human Genetics, McGill University, Montreal, Québec, Canada
Department of Medical Genetics, Research Institute of the McGill University Health Centre, Montreal, Québec, Canada

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Catherine S. Choong Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Subiaco, Washington, Australia
Faculty of Health and Medical Sciences, School of Medicine, The University of Western Australia, Crawley, Washington, Australia

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What Is Known about This Topic? Clinicians should be suspicious of an underlying genetic aetiology when a child or adolescent presents with nodular thyroid disease and a history of familial malignancy or syndrome-related diseases. Targeted

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Yasuhiro Ito Department of Surgery, Kuma Hospital, Shimoyamate-dori, Chuo-ku, Kobe, Hyogo, Japan

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Akira Miyauchi Department of Surgery, Kuma Hospital, Shimoyamate-dori, Chuo-ku, Kobe, Hyogo, Japan

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Introduction Papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) are major components of differentiated thyroid carcinoma (DTC) and are representative of malignancies that originate from the thyroid. Although both PTC and

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Mohamed Abdouh Cancer Research Program, McGill University Health Centre-Research Institute, Montreal, Québec, Canada

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Roger Tabah Department of Surgery and Department of Oncology, McGill University Health Centre, Montreal, Québec, Canada

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Vincenzo Arena Department of Obstetrics and Gynecology, Santo Bambino Hospital, Catania, Italy

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Manuel Arena Fondazione Istituto G. Giglio Cefalù, Pisciotto, Italy

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Zu-hua Gao Department of Pathology, McGill University Health Centre-Research Institute, Montreal, Québec, Canada

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Aurelio Lorico College of Medicine, Touro University Nevada, Henderson, Nevada, USA
Istituto Oncologico del Mediterraneo, Viagrande, Italy

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Goffredo Orazio Arena Fondazione Istituto G. Giglio Cefalù, Pisciotto, Italy
Istituto Oncologico del Mediterraneo, Viagrande, Italy
Department of Surgery, McGill University, St. Mary Hospital, Montreal, Québec, Canada

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Introduction Masses arising in the glands of the head and the neck regions are often seen in clinical practice, and the first priority is to determine whether they are benign or malignant. Malignancies of the head glands such as salivary

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Laura Ximena Kattah Martinez Pontificia Universidad Javeriana, Bogotá, Colombia

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Lisseth Fernanda Marín Carrillo Pontificia Universidad Javeriana, Bogotá, Colombia

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Leonardo Rojas Melo Pontificia Universidad Javeriana, Bogotá, Colombia

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associated with the development of acute pancreatitis of varying severity when used during the treatment of a broad range of malignancies. This meta-analysis also demonstrated that there was no significant effect on the type of neoplasm or the development of

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Meenu Gill Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Ashima Batra Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Ashok Sangwaiya Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Samta Shakya General Hospital, Sirsa, India

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Sumiti Gupta Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Rajeev Sen Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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) regimen with good response and is still under follow-up. Discussion PTL, with an estimated annual incidence of 2 cases per million, is a rare thyroid malignancy. Almost all cases are of B-cell origin. Thyroid is a rare site of primary extranodal

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Pedro Marques Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal

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Valeriano Leite Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

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Maria João Bugalho Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

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designated incidental PTCs; 159 (62.3%) patients had preoperative fine-needle aspiration cytology suggestive of thyroid malignancy (nonincidental PTCs). In 17 cases, the reason why surgery was performed was unknown. For assessment of risk recurrence the three

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