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Maik Pietzner Institute of Clinical Chemistry and Laboratory Medicine, Berlin, Germany

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Georg Homuth Interfaculty Institute for Genetics and Functional Genomics, Berlin, Germany

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Kathrin Budde Institute of Clinical Chemistry and Laboratory Medicine, Berlin, Germany

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Ina Lehmphul Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Uwe Völker Interfaculty Institute for Genetics and Functional Genomics, Berlin, Germany

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Henry Völzke Institute for Community Medicine, University Medicine Greifswald, Ernst Moritz Arndt University, Greifswald, Germany

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Matthias Nauck Institute of Clinical Chemistry and Laboratory Medicine, Berlin, Germany

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Nele Friedrich Institute of Clinical Chemistry and Laboratory Medicine, Berlin, Germany

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that related to T 4 and T 3 . Using this assay we recently observed a putative link between serum 3,5-T 2 and glucose but not lipid metabolism in euthyroid humans [ 13 ]. Expanding these initial rodent experimental and human observational findings

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Tania Pilli Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Silvia Cantara Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Lutz Schomburg Institute of Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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Valeria Cenci Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Sandro Cardinale Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Ellen C.D. Heid Institute of Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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Eike C. Kühn Institute of Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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Gabriele Cevenini Department of Medical Biotechnologies, University of Siena, Siena, Italy

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Fausta Sestini Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Carla Fioravanti Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Gabriele D'Hauw Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Furio Pacini Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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to evaluate, over 12 months, the effect of two different doses of Semet (80 or 160 µg/day) versus placebo in euthyroid women with AIT, in terms of modulation of established (reduction of anti-thyroid antibodies and improvement of thyroid echogenicity

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Kamilla R Riis Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

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Steen J Bonnema Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

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Anja F Dreyer Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

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Dorte Glintborg Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Niels Bilenberg Department of Child and Adolescent Mental Health, Mental Health Services in the Region of Southern Denmark, University of Southern Denmark Odense, Odense, Denmark

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Dorthe Bleses TrygFonden’s Centre for Child Research and School of Communication and Culture, Aarhus University, Aarhus, Denmark

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Fabio Trecca TrygFonden’s Centre for Child Research and School of Communication and Culture, Aarhus University, Aarhus, Denmark

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Marianne S Andersen Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

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language acquisition, i.e. the MB-CDI parent reports. Only one study, by Henrichs et al. ( 48 ), has previously employed this instrument for investigating the association between thyroid function in euthyroid treatment-naive women and productive language

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Mehtap Cakir Division of Endocrinology and Metabolism, Konya, Turkey

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Banu Turgut Ozturk Department of Ophthalmology, School of Medicine, Selcuk University, Konya, Turkey

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Elif Turan Division of Endocrinology and Metabolism, Konya, Turkey

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Gulsum Gonulalan Division of Endocrinology and Metabolism, Konya, Turkey

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Ilker Polat Departments of Internal Medicine, Konya, Turkey

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Kemal Gunduz Departments of Ophthalmology, Meram School of Medicine, Konya Necmettin Erbakan University, Konya, Turkey

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determine the effect of hypothyroidism on color contrast sensitivity by Chromatest in adult overt hypothyroid patients before and after euthyroidism is achieved and compare their color contrast sensitivity examination results with a euthyroid control group

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Henry Völzke Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Iris Erlund Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland

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Alicja Hubalewska-Dydejczyk Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland

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Till Ittermann Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Robin P. Peeters Department of Internal Medicine, Rotterdam Thyroid Centre, Erasmus Medical Centre, Rotterdam, The Netherlands

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Margaret Rayman University of Surrey, Surrey, United Kingdom

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Monika Buchberger Department of Public Health and Health Technology Assessment, UMIT, University for Health Science, Medical Informatics and Technology, Hall, Austria

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Uwe Siebert Department of Public Health and Health Technology Assessment, UMIT, University for Health Science, Medical Informatics and Technology, Hall, Austria

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Betina H. Thuesen Research Centre for Prevention and Health, Glostrup, Denmark

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Michael B. Zimmermann Swiss Federal Institute of Technology, Zürich Department of Health Sciences and Technology, Zürich, Switzerland

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Stefan Grünert Biolution GmbH, Vienna, Austria

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John H. Lazarus Institute of Molecular Medicine, Cardiff University, Cardiff, United Kingdom

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[ 6 ]. The review sums up experiences collected by the EUthyroid consortium so far and provides information on stakeholders that should be involved in actions directed to improve IDD prevention. This heterogeneity in national regulations poses

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Jorge Alberto Tapia-Martínez Laboratorio de Metabolismo I, Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Colonia Unidad Profesional Adolfo López Mateos, Delegación Gustavo A. Madero, Ciudad de México, México
Laboratorio 6, Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Delegación Tlalpan, Ciudad de México, México

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Margarita Franco-Colín Laboratorio de Metabolismo I, Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Colonia Unidad Profesional Adolfo López Mateos, Delegación Gustavo A. Madero, Ciudad de México, México

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Vanessa Blas-Valdivia Laboratorio de Neurobiología, Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Colonia Unidad Profesional Adolfo López Mateos, Delegación Gustavo A. Madero, Ciudad de México, México

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Edgar Cano-Europa Laboratorio de Metabolismo I, Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Colonia Unidad Profesional Adolfo López Mateos, Delegación Gustavo A. Madero, Ciudad de México, México

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perturbation worsens the clinical prognosis compared to the euthyroid group. Materials and methods Experimental design Eighteen virgin Wistar female rats were conditioned in controlled conditions (12 h light:12 h darkness cycle, temperature: 21 ± 1

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Kamilla R Riis Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Camilla B Larsen Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Bjarke R Medici Department of Medicine, Copenhagen University Hospital – Herlev and Gentofte, Denmark

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Christian Z Jensen Department of Medicine, Copenhagen University Hospital – Herlev and Gentofte, Denmark

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Kristian H Winther Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Emil L Larsen Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark

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Christina Ellervik Department of Laboratory Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Data and Data Support, Region Zealand, Sorø, Denmark

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Jeppe L la Cour Department of Medicine, Copenhagen University Hospital – Herlev and Gentofte, Denmark

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Thomas H Brix Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Henrik E Poulsen Department of Endocrinology, Copenhagen University Hospital, Bispebjerg-Frederiksberg Hospital, Denmark
Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
Department of Cardiology, University Hospital Nordsjælland, Hillerød, Denmark

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Filip K Knop Department of Medicine, Copenhagen University Hospital – Herlev and Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Birte Nygaard Department of Medicine, Copenhagen University Hospital – Herlev and Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Steen J Bonnema Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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urinary excretion of the oxidized guanine nucleosides 8-oxoGuo and 8-oxodG was monitored. Thus, all patients were examined twice, shortly after diagnosis and when euthyroidism had been restored by LT4 treatment for at least 6 months. The dose of LT4 was

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Annelies Tonnelier Departments of Endocrinology and General Internal Medicine, Algemeen Ziekenhuis Sint-Elisabeth Zottegem, Zottegem, Belgium

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Jeroen de Filette Departments of Endocrinology and General Internal Medicine, Algemeen Ziekenhuis Sint-Elisabeth Zottegem, Zottegem, Belgium

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Ann De Becker Departments of Hematology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels

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Sophie Deweer Department of Endocrinology and Diabetology, Algemeen Ziekenhuis Sint-Elisabeth Zottegem, Zottegem, Belgium

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Brigitte Velkeniers Departments of Endocrinology and General Internal Medicine, Algemeen Ziekenhuis Sint-Elisabeth Zottegem, Zottegem, Belgium

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What Is Known about This Topic? • Thyroidectomy is a valid alternative for patients with severe amiodarone-induced thyrotoxicosis, or refractoriness or contraindications to medical therapy. Restoring a euthyroid state prior to thyroidectomy is

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Claudio Marcocci Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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Marenza Leo Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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Maria Antonietta Altea Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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euthyroid animals [ 10 ]. In the same animals, erythrocyte antioxidant parameters (SOD, GPx) were also increased as a response to the sustained oxidative stress induced by thyrotoxicosis. Interestingly, the concomitant administration of vitamin E – a potent

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Bernard Goichot Department of Internal Medicine, Endocrinology and Nutrition, Hôpitaux Universitaires de Strasbourg
FMTS, Faculté de Médecine, Université de Strasbourg, Strasbourg

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Stéphane Bouée CEMKA, Bourg La Reine

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Claire Castello-Bridoux Medical Affairs Department, Merck Serono, Lyon

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Philippe Caron Department of Endocrinology, Metabolic Diseases and Nutrition, Pôle Cardio-Vasculaire et Métabolique, CHU Larrey
Inserm U1037, Université Paul Sabatier, Toulouse, France

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, especially the drugs used (names and dosage of synthetic antithyroid drugs, concomitant treatments ( L -thyroxine in the “block and replace” protocol, β-blockers, anxiolytics). At 3 months, the questionnaire reported thyroid status (euthyroid, hyper- or

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