Valentina M. Drozd
Valentina M. Drozd
The International Fund “Help for patients with radiation-induced thyroid cancer ‘Arnica’”, Minsk, Belarus
Project Chernobyl, Brooklyn, New York, USA
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Project Chernobyl, Brooklyn, New York, USA
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Igor Branovan
Igor Branovan
Project Chernobyl, Brooklyn, New York, USA
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Nikolay Shiglik
Nikolay Shiglik
Project Chernobyl, Brooklyn, New York, USA
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Johannes Biko
Johannes Biko
Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany
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Christoph Reiners
Christoph Reiners
The International Fund “Help for patients with radiation-induced thyroid cancer ‘Arnica’”, Minsk, Belarus
Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany
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Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany
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Introduction During the last 30 years, the incidence of differentiated thyroid cancer (DTC) has steadily increased worldwide, most markedly in France, Italy, the Republic of Korea, Australia, and the USA [ 1 - 8 ]. In the USA, DTC incidence is
Inês Cosme
Inês Cosme
Department of Endocrinology, Unidade Local de Saúde Santa Maria, Lisbon, Portugal
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Ana Figueiredo
Ana Figueiredo
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Sara Pinheiro
Sara Pinheiro
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Introduction The incidence of thyroid carcinoma (TC) increased over the past 50 years ( 1 , 2 ) mainly due to a disproportionate increase in small papillary TC ( 3 ). In 2020, the GLOBOCAN database reported worldwide 586,000 cases of TC
Catherine Brophy
Catherine Brophy
Departments of Otolaryngology - Head and Neck Surgery, Cork, Ireland
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Rania Mehanna
Rania Mehanna
Departments of Otolaryngology - Head and Neck Surgery, Cork, Ireland
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Julie McCarthy
Julie McCarthy
Departments of Cytopathology, Cork University Hospital, Cork, Ireland
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Antoinette Tuthill
Antoinette Tuthill
Departments of Endocrinology, Cork University Hospital, Cork, Ireland
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Matthew S. Murphy
Matthew S. Murphy
Departments of Endocrinology, South Infirmary Victoria University Hospital, Cork, Ireland
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Patrick Sheahan
Patrick Sheahan
Departments of Otolaryngology - Head and Neck Surgery, Cork, Ireland
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Introduction Thyroid nodules are common, being present by palpation in up to 5% of individuals and by ultrasonography (US) in up to 50% [ 1 ]. While the overwhelming majority are benign, it is estimated that the incidence of cancer in
Line Tang Møllehave
Line Tang Møllehave
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Nils Knudsen
Nils Knudsen
Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Denmark
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Allan Linneberg
Allan Linneberg
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Inge Bülow Pedersen
Inge Bülow Pedersen
Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark
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Gitte Ravn-Haren
Gitte Ravn-Haren
Research Group for Risk Benefit, National Food Institute, Technical University of Denmark, Lyngby, Denmark
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Anja Lykke Madsen
Anja Lykke Madsen
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Allan Carlé
Allan Carlé
Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark
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Charlotte Cerqueira
Charlotte Cerqueira
The Danish Clinical Quality Program – National Clinical Registries (RKKP), Denmark
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Anne Krejbjerg
Anne Krejbjerg
Department of Oncology, Aalborg University Hospital, Aalborg, Denmark
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Lone Banke Rasmussen
Lone Banke Rasmussen
Independent researcher, Klemensker, Denmark
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Lars Ovesen
Lars Ovesen
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Hans Perrild
Hans Perrild
Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Denmark
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Lena Bjergved Sigurd
Lena Bjergved Sigurd
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark
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Department of Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark
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Betina Heinsbæk Thuesen
Betina Heinsbæk Thuesen
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Pernille Vejbjerg
Pernille Vejbjerg
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Torben Jørgensen
Torben Jørgensen
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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(11.8–12.2 mL, P < 0.001) ( 58 ). Effects on thyroid disorders Hyperthyroidism The laboratory studies found that before IF, in 1997–1998, the incidence of overt hyperthyroidism was 128.5 and 80.1 per 100,000 person-years (PY) in western
Juan J. Lence-Anta
Juan J. Lence-Anta
Institute of Oncology and Radiobiology, Havana, Cuba
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Constance Xhaard
Constance Xhaard
Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba
Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France
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Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France
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Rosa M. Ortiz
Rosa M. Ortiz
Institute of Oncology and Radiobiology, Havana, Cuba
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Haoiinda Kassim
Haoiinda Kassim
Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba
Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France
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Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France
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Celia M. Pereda
Celia M. Pereda
Institute of Oncology and Radiobiology, Havana, Cuba
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Silvia Turcios
Silvia Turcios
National Institute of Endocrinology, Havana, Cuba
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Milagros Velasco
Milagros Velasco
Institute of Oncology and Radiobiology, Havana, Cuba
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Mae Chappe
Mae Chappe
Institute of Oncology and Radiobiology, Havana, Cuba
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Idalmis Infante
Idalmis Infante
Institute of Oncology and Radiobiology, Havana, Cuba
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Marlene Bustillo
Marlene Bustillo
Institute of Oncology and Radiobiology, Havana, Cuba
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Anabel García
Anabel García
Institute of Oncology and Radiobiology, Havana, Cuba
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Enora Clero
Enora Clero
Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba
Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France
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Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France
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Stephane Maillard
Stephane Maillard
Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba
Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France
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Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France
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Sirced Salazar
Sirced Salazar
Institute of Oncology and Radiobiology, Havana, Cuba
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Regla Rodriguez
Regla Rodriguez
Cuban Health Public Ministry, Havana, Cuba
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Florent de Vathaire
Florent de Vathaire
Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba
Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France
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Institut Gustave Roussy, Havana, Cuba
University Paris-Sud, Villejuif, France
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Introduction Registering the incidence of differentiated thyroid carcinoma (DTC) is highly dependent on the medical practice and, in particular, on organized or opportunistic screening [ 1 ]. Therefore, comparing reported incidences requires
Maria Rossing
Maria Rossing
Department of Endocrinology, Herlev University Hospital, Herlev
Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark
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Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark
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Birte Nygaard
Birte Nygaard
Department of Endocrinology, Herlev University Hospital, Herlev
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Finn Cilius Nielsen
Finn Cilius Nielsen
Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark
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Finn Noe Bennedbæk
Finn Noe Bennedbæk
Department of Endocrinology, Herlev University Hospital, Herlev
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Frates et al. [ 7 ] the accumulated predicted value of US characteristics and basic clinical features ranged between 3 and 48%. The papillary thyroid microcarcinoma (PTMC) is a papillary thyroid carcinoma with a size of ≤1 cm. The overall incidence of
Lan Wu
Lan Wu
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
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Salvatore Vaccarella
Salvatore Vaccarella
International Agency for Research on Cancer (IARC/WHO), Lyon, France
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Chen-Yang Feng
Chen-Yang Feng
Information Technology Center, Sun Yat-sen University Cancer Center, Guangzhou, China
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Luigino Dal Maso
Luigino Dal Maso
Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy
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Yu Chen
Yu Chen
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
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Wei-Wei Liu
Wei-Wei Liu
Department of Head and Neck, Sun Yat-sen University Cancer Center, Guangzhou, China
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Miao-Bian Liang
Miao-Bian Liang
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
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Zike Zhang
Zike Zhang
Department of Laboratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
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Jun Yang
Jun Yang
School of Public Health, Guangzhou Medical University, Guangzhou, China
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Su-Mei Cao
Su-Mei Cao
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
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Mengmeng Li
Mengmeng Li
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
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Introduction Thyroid cancer is the most common cancer in the endocrine system, and its incidence rates have increased rapidly worldwide over the past decades, with relatively stable or declining mortality rates ( 1 , 2 ). The diverging gap
L.A. Jonker
L.A. Jonker
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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C.A. Lebbink
C.A. Lebbink
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M.C.J. Jongmans
M.C.J. Jongmans
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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R.A.J. Nievelstein
R.A.J. Nievelstein
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Pediatric Radiology and Nuclear Medicine, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Radiology and Nuclear Medicine, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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J.H.M. Merks
J.H.M. Merks
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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E.J.M. Nieveen van Dijkum
E.J.M. Nieveen van Dijkum
Department of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands
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T.P. Links
T.P. Links
Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
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N. Hoogerbrugge
N. Hoogerbrugge
Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands
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A.S.P. van Trotsenburg
A.S.P. van Trotsenburg
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands
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H.M. van Santen
H.M. van Santen
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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any childhood cancer may be justified when its incidence reaches 5%, also for tumors with a good prognosis [ 8 , 9 ]. For this reason, the first question that needs to be answered is about the incidence of DTC in children with PHTS. The second
Carla Colombo
Carla Colombo
Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Daniele Ceruti
Daniele Ceruti
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Simone De Leo
Simone De Leo
Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
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Grzegorz Bilo
Grzegorz Bilo
Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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Matteo Trevisan
Matteo Trevisan
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Noemi Giancola
Noemi Giancola
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Claudia Moneta
Claudia Moneta
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Gianfranco Parati
Gianfranco Parati
Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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Luca Persani
Luca Persani
Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Laura Fugazzola
Laura Fugazzola
Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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most frequent toxicities recorded during both clinical trials and real-life (RL) studies and has a high incidence during LEN treatment (reviewed in Table 1 ). Indeed, in the LEN registration trial SELECT, it was recorded in 67.8% of cases, and 41.8% of
Dillwyn Williams
Dillwyn Williams
Department of Public Health, University of Cambridge, Cambridge, UK
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areas needs to be considered: the age-specific incidence of thyroid malignancy, the age-related sensitivity to radiation-induced thyroid cancer, the molecular findings in malignancy, the cell of origin of thyroid carcinomas, and the growth pattern of the
