Rudolf Hoermann
Rudolf Hoermann
Department of Nuclear Medicine, Klinikum Luedenscheid, Luedenscheid, Germany
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John E.M. Midgley
John E.M. Midgley
North Lakes Clinical, Ilkley, UK
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Rolf Larisch
Rolf Larisch
Department of Nuclear Medicine, Klinikum Luedenscheid, Luedenscheid, Germany
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Johannes W. Dietrich
Johannes W. Dietrich
Medical Department I, Endocrinology and Diabetology, Bergmannsheil University Hospitals, Ruhr University of Bochum
Ruhr Center for Rare Diseases (CeSER), Ruhr University of Bochum and Witten/Herdecke University, Bochum, Germany
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Ruhr Center for Rare Diseases (CeSER), Ruhr University of Bochum and Witten/Herdecke University, Bochum, Germany
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3 ) and FT 4 , which also maintain interdependent equilibrium positions. While allowing for greater flexibility in the physiological responses of individuals across the euthyroid reference range, this may demand significant variation in the
Shinsuke Shinkai
Shinsuke Shinkai
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
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Kenji Ohba
Kenji Ohba
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
Medical Education Center, Hamamatsu University School of Medicine, Shizuoka, Japan
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Medical Education Center, Hamamatsu University School of Medicine, Shizuoka, Japan
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Kennichi Kakudo
Kennichi Kakudo
Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Osaka, Japan
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Takayuki Iwaki
Takayuki Iwaki
Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan
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Yoshihiro Mimura
Yoshihiro Mimura
Department of Internal Medicine, American Hospital of Paris, Neuilly sur Seine, France
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Akio Matsushita
Akio Matsushita
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
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Go Kuroda
Go Kuroda
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
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Yuki Sakai
Yuki Sakai
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
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Nobuhiko Nishino
Nobuhiko Nishino
Department of Surgery, Maruyama Hospital, Shizuoka, Japan
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Kazuo Umemura
Kazuo Umemura
Medical Education Center, Hamamatsu University School of Medicine, Shizuoka, Japan
Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan
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Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan
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Takafumi Suda
Takafumi Suda
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
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Shigekazu Sasaki
Shigekazu Sasaki
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
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of 0.01 mIU/L (reference range: 0.05–5.00), a free thyroxine level of 23.2 pmol/L (reference range: 11.6–21.9), and a free tri-iodothyronine level of 6.6 pmol/L (reference range: 3.5–6.2) as measured by ECLusys (Roche Diagnostics K.K., Tokyo, Japan
Tina Toft Kristensen
Tina Toft Kristensen
Department of Otorhinolaryngology, Head and Neck Surgery, Køge Hospital, Region Zealand, Køge
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Jacob Larsen
Jacob Larsen
Departments of Clinical Pathology, Næstved Hospital, Region Zealand, Næstved, Denmark
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Palle Lyngsie Pedersen
Palle Lyngsie Pedersen
Departments of Clinical Biochemistry, Næstved Hospital, Region Zealand, Næstved, Denmark
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Anne-Dorthe Feldthusen
Anne-Dorthe Feldthusen
Departments of Gynecology and Obstetrics, Næstved Hospital, Region Zealand, Næstved, Denmark
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Christina Ellervik
Christina Ellervik
Departments of Clinical Biochemistry, Næstved Hospital, Region Zealand, Næstved, Denmark
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Søren Jelstrup
Søren Jelstrup
Department of Otorhinolaryngology, Head and Neck Surgery, Køge Hospital, Region Zealand, Køge
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Jan Kvetny
Jan Kvetny
Internal Medicine, Næstved Hospital, Region Zealand, Næstved, Denmark
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Introduction Whereas hemithyroidectomy is associated with a recognized risk of overt hypothyroidism [ 1 ], the significance of perturbations of thyroid-stimulating hormone (TSH) and thyroid hormones within the laboratory reference ranges after
Cléber P. Camacho
Cléber P. Camacho
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Susan C. Lindsey
Susan C. Lindsey
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Teresa S. Kasamatsu
Teresa S. Kasamatsu
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Alberto L. Machado
Alberto L. Machado
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
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Fleury Medicine and Health, São Paulo, Brazil
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João Roberto M. Martins
João Roberto M. Martins
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Rosa Paula M. Biscolla
Rosa Paula M. Biscolla
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
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Fleury Medicine and Health, São Paulo, Brazil
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Magnus R. Dias da Silva
Magnus R. Dias da Silva
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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José Gilberto H. Vieira
José Gilberto H. Vieira
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
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Fleury Medicine and Health, São Paulo, Brazil
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Rui M.B. Maciel
Rui M.B. Maciel
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
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Fleury Medicine and Health, São Paulo, Brazil
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diagnosis of nodular thyroid disease (NTD) while other guidelines assume a neutral or a contrary position regarding the use of sCT for NTD due to false-positive results, cost-effectiveness, and large reference range of assays [ 2 , 3 , 4 , 5 , 6 , 7 , 8
Marise Codeco de Andrade Barreto
Marise Codeco de Andrade Barreto
Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Natalia Treistman
Natalia Treistman
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Lara Bessa Campelo Pinheiro Cavalcante
Lara Bessa Campelo Pinheiro Cavalcante
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Daniel Bulzico
Daniel Bulzico
Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
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Fernanda Accioly de Andrade
Fernanda Accioly de Andrade
Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
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Rossana Corbo
Rossana Corbo
Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
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Paulo Alonso Garcia Alves Junior
Paulo Alonso Garcia Alves Junior
Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Fernanda Vaisman
Fernanda Vaisman
Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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.01–7.81) AMH out-of-reference range for age 10 (21) N/A Age at AMH measurement 47 (100) 26.1 ± 9.2 25 (12.4–50.8) Interval (years) between last RAI and AMH measurement 47 (100) 10.7 ± 7.2 10.5 (0.7–26.2) Pregnancies ( n = 17
Tilman Witte
Tilman Witte
The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, Lebanon, N.H., USA
Institute for Community Medicine, Greifswald, Germany
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Institute for Community Medicine, Greifswald, Germany
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Henry Völzke
Henry Völzke
Institute for Community Medicine, Greifswald, Germany
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Markus M. Lerch
Markus M. Lerch
Departments of Medicine A, Greifswald, Germany
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Katrin Hegenscheid
Katrin Hegenscheid
Departments of Diagnostic Radiology, Greifswald, Germany
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Nele Friedrich
Nele Friedrich
Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald School of Medicine, Greifswald, Germany
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Till Ittermann
Till Ittermann
Institute for Community Medicine, Greifswald, Germany
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John A. Batsis
John A. Batsis
The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, Lebanon, N.H., USA
Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, N.H., USA
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Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, N.H., USA
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Introduction Both thyroid disease and obesity are common disorders in the general population. Several studies have found a prevalence dependent on selected reference ranges from 0.1 to 2% for hypothyroidism [elevated thyroid
Laura P.B. Elbers
Laura P.B. Elbers
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Hjalmar A. Boon
Hjalmar A. Boon
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
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Maaike I. Moes
Maaike I. Moes
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
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Bregje van Zaane
Bregje van Zaane
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Dees P.M. Brandjes
Dees P.M. Brandjes
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Eric Fliers
Eric Fliers
Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam
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Harry R. Büller
Harry R. Büller
Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Suzanne Cannegieter
Suzanne Cannegieter
Department of Clinical Epidemiology, Leiden University Medical Center
Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Victor E.A. Gerdes
Victor E.A. Gerdes
Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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Departments of Vascular Medicine, University of Amsterdam, Amsterdam
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reference range had an increased risk of major bleeding compared to those with higher FT 4 levels, suggesting that FT 4 levels play a role in the etiology of major bleeding in VKA users. Bleeding is one of the major short-term complications after
Marta Kostecka-Matyja
Marta Kostecka-Matyja
Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow
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Anna Fedorowicz
Anna Fedorowicz
Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow
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Ewa Bar-Andziak
Ewa Bar-Andziak
Department of Internal Medicine and Endocrinology, Medical University, Warsaw
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Tomasz Bednarczuk
Tomasz Bednarczuk
Department of Internal Medicine and Endocrinology, Medical University, Warsaw
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Monika Buziak-Bereza
Monika Buziak-Bereza
Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow
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Paulina Dumnicka
Paulina Dumnicka
Department of Medical Diagnostics, Jagiellonian University, Collegium Medicum, Krakow
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Maria Górska
Maria Górska
Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok
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Małgorzata Krasnodębska
Małgorzata Krasnodębska
Department of Internal Medicine and Endocrinology, Medical University, Warsaw
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Beata Niedźwiedzka
Beata Niedźwiedzka
Department of Internal Medicine and Endocrinology, Medical University, Warsaw
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Dorota Pach
Dorota Pach
Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow
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Marek Ruchała
Marek Ruchała
Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, Poznan
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Katarzyna Siewko
Katarzyna Siewko
Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok
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Bogdan Solnica
Bogdan Solnica
Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University, Collegium Medicum, Krakow, Poland
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Jerzy Sowiński
Jerzy Sowiński
Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, Poznan
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Małgorzata Szelachowska
Małgorzata Szelachowska
Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok
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Małgorzata Trofimiuk-Müldner
Małgorzata Trofimiuk-Müldner
Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow
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Katarzyna Wachowiak-Ochmańska
Katarzyna Wachowiak-Ochmańska
Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, Poznan
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Alicja Hubalewska-Dydejczyk
Alicja Hubalewska-Dydejczyk
Chair and Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow
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determine reference intervals for thyroid hormones by local laboratories [ 13 ]. The reference ranges established for the general population are not relevant for pregnant women. Also, since the rapid hormonal changes during pregnancy must be addressed, there
Françoise Brucker-Davis
Françoise Brucker-Davis
Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Patricia Panaïa-Ferrari
Patricia Panaïa-Ferrari
Departments of Biochemistry, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Jocelyn Gal
Jocelyn Gal
Departments of Biostatistics, CHU de Nice, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Patrick Fénichel
Patrick Fénichel
Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Sylvie Hiéronimus
Sylvie Hiéronimus
Department of Endocrinology, Diabetology and Reproductive Medicine
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5th or 10th percentile of the reference range for FT4 associated with normal TSH [ 3 , 4 ]. There is, however, the question of threshold for normal values, linked in part to the lack of laboratory reference ranges in pregnancy. The association of
Selwan Khamisi
Selwan Khamisi
Department of Endocrinology and Diabetes, Uppsala University, Uppsala, Sweden
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Peter Lindgren
Peter Lindgren
Women's and Children's Health, University Hospital, Uppsala University, Uppsala, Sweden
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F. Anders Karlsson
F. Anders Karlsson
Department of Endocrinology and Diabetes, Uppsala University, Uppsala, Sweden
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University Hospital. Reference ranges for amniotic TSH (0.04-0.51 mU/l) and fT 4 (1.29-9.93 pmol/l) are based on the study by Baumann and Gronowski 2007 [ 12 ]. The ultrasound equipment used was Voluson E8, Expert (General Electric Co./GE Healthcare
