Otorhinolaryngology, Tan Tock Seng Hospital, Singapore, Singapore
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Otolaryngology, Head and Neck Surgery, Sheba Medical Center, Ramat Gan, Israel
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-oncogene. Laboratory tests revealed a basal calcitonin level of 3,786 ng/L and carcinoembryonic antigen (CEA) level of 286.8 ng/mL. Parathyroid hormone, serum calcium, and 24-hour urinary catecholamines were within the normal range. Computed tomography (CT) of the neck
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tumour with until recently few treatment opportunities other than surgery. However, in the past, these calcitonin-secreting cells and their homologous counterparts in lower vertebrates (in which C cells are present outside the thyroid) played a prominent
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endocrine secretions of carcinomas can be life-threatening. Medullary thyroid carcinoma (MTC) is a rare cancer that is often responsible not only for hormone secretion, mainly calcitonin secretion, but also possibly adrenocorticotrophic hormone (ACTH
Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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, early diagnosis of the primary tumor and metastases is essential for outcomes. Basal calcitonin (bCt) and carcinoembryonic antigen (CEA) can be used for diagnosis and follow-up of MTC. In case of increased bCt levels, a calcium stimulation test may be
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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Department of Pathology, Haukeland University Hospital Bergen, Bergen, Norway
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Department of Medical Genetics, St. Olavs University Hospital, Trondheim, Norway
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Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
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improved due to better sensitivity and increased use of biochemical, radiological, and cytological examinations, hence making MTC diagnosis possible at lower tumor stages [ 3 , 12 , 13 ]. Calcitonin is a good tumor marker in diagnostics and follow
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elevated serum calcitonin (Ct) or carcinoembryonic antigen (CEA) levels. In fact, serum markers remain detectable after initial treatment in a significant percentage of patients, and more frequently in those with large thyroid tumors, tumor extension beyond
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. All patients underwent a biochemical and hormone examination before and after the study, including fasting plasma glucose (FPG), post-prandial glucose (PPG), glycated haemoglobin (HbA 1c ), thyroid function tests, thyroid antibodies, and calcitonin
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Introduction Medullary thyroid cancer (MTC) is a neuroendocrine tumor arising from parafollicular or calcitonin-producing C cells that retain the biochemical and pathological features of the cells from which it derives. MTC accounts for 3
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necessary if there is lateral lymph node compartment involvement ( 2 ). MTC follow-up is then based on a periodical neck ultrasound (US) and biochemical follow-up, based primarily on calcitonin (Ct) and carcinoembryonic antigen (CEA) measurement. Ct is
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selpercatinib. Introduction Serum tumour markers are important tools in the management of patients with medullary thyroid carcinoma (MTC) ( 1 ). Serum calcitonin (CT) and carcinoembryonic antigen (CEA) are produced by neoplastic C-cells, and their