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Rudolf Hoermann Department of Nuclear Medicine, Klinikum Luedenscheid, Luedenscheid, Germany

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John E.M. Midgley North Lakes Clinical, Ilkley, UK

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Rolf Larisch Department of Nuclear Medicine, Klinikum Luedenscheid, Luedenscheid, Germany

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Johannes W. Dietrich Medical Department I, Endocrinology and Diabetology, Bergmannsheil University Hospitals, Ruhr University of Bochum
Ruhr Center for Rare Diseases (CeSER), Ruhr University of Bochum and Witten/Herdecke University, Bochum, Germany

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3 ) and FT 4 , which also maintain interdependent equilibrium positions. While allowing for greater flexibility in the physiological responses of individuals across the euthyroid reference range, this may demand significant variation in the

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000447967
Volume/Issue:
Volume 5: Issue 3
Free access
Linda M. Thienpont Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent

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Katleen Van Uytfanghe Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent

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Sofie Van Houcke Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent

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Barnali Das Biochemistry and Immunology Laboratory, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India

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James D. Faix Stanford University School of Medicine, Palo Alto, Calif., Abbott Park, Ill., USA

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Finlay MacKenzie Birmingham Quality/UK NEQAS, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Frank A. Quinn Medical and Scientific Affairs, Abbott Diagnostics, Abbott Laboratories, Abbott Park, Ill., USA

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Michael Rottmann Roche Diagnostics GmbH, Penzberg, Germany

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Annick Van den Bruel Department of Endocrinology, General Hospital Sint Jan, Bruges, Belgium

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<9 pmol/l). This reconfirmed that, currently, FT4 measurement results outside the range of one assay are well within that of another, which can confuse clinicians when they do not consider assay-specific reference intervals. For TSH, concentration

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000358270
Volume/Issue:
Volume 3: Issue 2
Open access
John Lazarus Thyroid Research Group, Institute of Molecular Medicine, Cardiff University, University Hospital of Wales, Cardiff

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Rosalind S. Brown Clinical Trials Research Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, Mass., USA

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Chantal Daumerie Endocrinologie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

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Alicja Hubalewska-Dydejczyk Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Bijay Vaidya Department of Endocrinology, Royal Devon and Exeter Hospital and University of Exeter Medical School, Exeter, UK

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Introduction Subclinical hypothyroidism (SCH) in pregnancy is defined by a serum thyroid-stimulating hormone (TSH) concentration higher than the upper limit of the pregnancy-related reference range associated with a normal serum thyroxine [T 4

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000362597
Volume/Issue:
Volume 3: Issue 2
Free access
Till Ittermann Institute for Community Medicine, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

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Roberto Lorbeer Institute for Community Medicine, Germany

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Daniel Tiller Institute of Medical Epidemiology, Biostatistics and Informatics, Germany

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Ina Lehmphul Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Alexander Kluttig Institute of Medical Epidemiology, Biostatistics and Informatics, Germany

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Stephan B. Felix Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

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Karl Werdan Department of Medicine III, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

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Karin Halina Greiser German Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg, Germany

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Henry Völzke Institute for Community Medicine, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

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Marcus Dörr Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

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1 ). In all three studies individuals with a TSH <0.3 mIU/l were in the median older than individuals with a TSH in the reference range. This difference was more pronounced in the SHIP studies than in CARLA. In the SHIP studies, individuals with a

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000381309
Volume/Issue:
Volume 4: Issue 1_Suppl
Free access
Laura P.B. Elbers Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Hjalmar A. Boon Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam

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Maaike I. Moes Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam

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Bregje van Zaane Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Dees P.M. Brandjes Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Eric Fliers Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam

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Harry R. Büller Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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Suzanne Cannegieter Department of Clinical Epidemiology, Leiden University Medical Center
Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Victor E.A. Gerdes Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Amsterdam
Departments of Vascular Medicine, University of Amsterdam, Amsterdam

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reference range had an increased risk of major bleeding compared to those with higher FT 4 levels, suggesting that FT 4 levels play a role in the etiology of major bleeding in VKA users. Bleeding is one of the major short-term complications after

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000446431
Volume/Issue:
Volume 5: Issue 2
Open access
Shinsuke Shinkai Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan

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Kenji Ohba Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
Medical Education Center, Hamamatsu University School of Medicine, Shizuoka, Japan

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Kennichi Kakudo Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Osaka, Japan

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Takayuki Iwaki Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan

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Yoshihiro Mimura Department of Internal Medicine, American Hospital of Paris, Neuilly sur Seine, France

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Akio Matsushita Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan

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Go Kuroda Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan

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Yuki Sakai Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan

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Nobuhiko Nishino Department of Surgery, Maruyama Hospital, Shizuoka, Japan

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Kazuo Umemura Medical Education Center, Hamamatsu University School of Medicine, Shizuoka, Japan
Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan

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Takafumi Suda Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan

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Shigekazu Sasaki Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan

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of 0.01 mIU/L (reference range: 0.05–5.00), a free thyroxine level of 23.2 pmol/L (reference range: 11.6–21.9), and a free tri-iodothyronine level of 6.6 pmol/L (reference range: 3.5–6.2) as measured by ECLusys (Roche Diagnostics K.K., Tokyo, Japan

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000513552
Volume/Issue:
Volume 10: Issue 3
Free access
Thea Riis Department of Endocrinology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Thomas Heiberg Brix Department of Endocrinology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Lars Folkestad Department of Endocrinology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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.8 2.9 2.1  >3 3.2 1.9 2.8 2.1 2.4 1.5 CCI, Charlson Comorbidity Index; HT, hyperthyroid; HTP, hyperthyroid population; IQR, interquartile range; n , total number of events; RP, reference population. Risk of

Article Type:
Research Article
Collections:
Hyperthyroidism and thyrotoxicosis
DOI:
https://doi.org/10.1530/ETJ-23-0181
Volume/Issue:
Volume 13: Issue 2
Open access
Tina Toft Kristensen Department of Otorhinolaryngology, Head and Neck Surgery, Køge Hospital, Region Zealand, Køge

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Jacob Larsen Departments of Clinical Pathology, Næstved Hospital, Region Zealand, Næstved, Denmark

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Palle Lyngsie Pedersen Departments of Clinical Biochemistry, Næstved Hospital, Region Zealand, Næstved, Denmark

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Anne-Dorthe Feldthusen Departments of Gynecology and Obstetrics, Næstved Hospital, Region Zealand, Næstved, Denmark

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Christina Ellervik Departments of Clinical Biochemistry, Næstved Hospital, Region Zealand, Næstved, Denmark

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Søren Jelstrup Department of Otorhinolaryngology, Head and Neck Surgery, Køge Hospital, Region Zealand, Køge

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Jan Kvetny Internal Medicine, Næstved Hospital, Region Zealand, Næstved, Denmark

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Introduction Whereas hemithyroidectomy is associated with a recognized risk of overt hypothyroidism [ 1 ], the significance of perturbations of thyroid-stimulating hormone (TSH) and thyroid hormones within the laboratory reference ranges after

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000357943
Volume/Issue:
Volume 3: Issue 1
Free access
Joke Marlier Department of Endocrinology, Ghent University Hospital, Ghent, Belgium

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Guy T’Sjoen Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium

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Jean Kaufman Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium

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Bruno Lapauw Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium

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/kg body weight, aiming for free thyroxine serum levels (fT4) prior to intake in the upper part of normal reference ranges ( 1 ). However, variability in TH absorption and metabolism, concomitant treatments and inaccurate interpretation of TSH levels still

Article Type:
Research Article
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1530/ETJ-21-0128
Volume/Issue:
Volume 11: Issue 6
Open access
Marise Codeco de Andrade Barreto Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Natalia Treistman Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Lara Bessa Campelo Pinheiro Cavalcante Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Daniel Bulzico Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil

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Fernanda Accioly de Andrade Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil

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Rossana Corbo Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil

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Paulo Alonso Garcia Alves Junior Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Fernanda Vaisman Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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.01–7.81) AMH out-of-reference range for age 10 (21) N/A Age at AMH measurement 47 (100) 26.1 ± 9.2 25 (12.4–50.8) Interval (years) between last RAI and AMH measurement 47 (100) 10.7 ± 7.2 10.5 (0.7–26.2) Pregnancies ( n = 17

Article Type:
Research Article
Collections:
Pediatric thyroid diseases
DOI:
https://doi.org/10.1530/ETJ-23-0252
Volume/Issue:
Volume 13: Issue 2
Open access