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Marie Alix Balay
Marie Alix Balay
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Patrick Aidan
Patrick Aidan
American Hospital of Paris, Neuilly sur Seine, France
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Marie Helene Schlageter
Marie Helene Schlageter
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Odette Georges
Odette Georges
American Hospital of Paris, Neuilly sur Seine, France
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Taly Meas
Taly Meas
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Maroun Bechara
Maroun Bechara
American Hospital of Paris, Neuilly sur Seine, France
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Marie Elisabeth Toubert
Marie Elisabeth Toubert
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Isabelle Faugeron
Isabelle Faugeron
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Herve Monpeyssen
Herve Monpeyssen
American Hospital of Paris, Neuilly sur Seine, France
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Cécile N. Chougnet
Cécile N. Chougnet
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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treatment are summarized in Table 2 . At the time of RAI therapy, the median stimulated Tg level was 4.5 ng/mL (range 0.16–125 ng/mL) and 7 patients had anti-Tg Ab. At that time, 3 patients had a suspicious cervical lymph node on ultrasonography. Table
L. Leenhardt
L. Leenhardt
Department of Nuclear Medicine, Pitié Salpêtrière Hospital, Cancer Institute, Pierre et Marie Curie University, Paris, France
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M.F. Erdogan
M.F. Erdogan
Department of Endocrinology and Metabolism, University of Ankara School of Medicine, İbni Sina Hastanesi, Ankara, Turkey
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L. Hegedus
L. Hegedus
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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S.J. Mandel
S.J. Mandel
Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa., USA
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R. Paschke
R. Paschke
Department of Endocrinology, University of Leipzig, Leipzig, Germany
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T. Rago
T. Rago
Endocrine Unit 1, Department of Internal Medicine, Ospedale Cisanello, University of Pisa, Pisa, Italy
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G. Russ
G. Russ
Department of Nuclear Medicine, Pitié Salpêtrière Hospital, Cancer Institute, Pierre et Marie Curie University, Paris, France
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characteristics) (fig. 5 ): Fig. 5 Cervical lymph node metastasis. - Microcalcifications. - Partially cystic appearance. - Peripheral or diffusely increased vascularization. - Hyperechoic tissue looking like thyroid. Small LNs are
Shaodong Hou
Shaodong Hou
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China
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Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China
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Yiceng Sun
Yiceng Sun
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Zeyu Yang
Zeyu Yang
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Mi Tang
Mi Tang
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Tingjie Yin
Tingjie Yin
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Cong Shao
Cong Shao
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Cunye Yan
Cunye Yan
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Linlong Mo
Linlong Mo
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Yuquan Yuan
Yuquan Yuan
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Supeng Yin
Supeng Yin
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
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Fan Zhang
Fan Zhang
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China
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Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China
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biopsy specimens for diagnosing cervical lymph node metastasis in patients with papillary thyroid cancer . World Journal of Surgery 2005 29 483 – 485 . ( https://doi.org/10.1007/s00268-004-7701-0 ) 11 Moon JH Kim YI Lim JA Choi HS Cho SW Kim
Fahim U. Hassan
Fahim U. Hassan
Nuclear Medicine Department, Borough Wing, Guy's Hospital, London, UK
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Hosahalli K. Mohan
Hosahalli K. Mohan
Nuclear Medicine Department, Borough Wing, Guy's Hospital, London, UK
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patients had pathological cervical lymphadenopathy which was non-radioiodine avid. They were referred for surgical clearance of lymph nodes; this confirmed de-differentiated disease. In the thorax, 5 patients had mediastinal disease and 8 had lung
Hélène Théodon
Hélène Théodon
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Erell Guillerm
Erell Guillerm
Department of Oncogenetic, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Johanna Wassermann
Johanna Wassermann
Department of Oncology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Gabrielle Deniziaut
Gabrielle Deniziaut
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Loïc Jaffrelot
Loïc Jaffrelot
Department of Oncology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Jérome Denis
Jérome Denis
Department of Endocrine and Oncology Biochemistry, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris, France
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Nathalie Chereau
Nathalie Chereau
Department of Endocrine Surgery, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Claude Bigorgne
Claude Bigorgne
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Wiame Potonnier
Wiame Potonnier
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Florence Coulet
Florence Coulet
Department of Oncogenetic, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Laurence Leenhardt
Laurence Leenhardt
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Camille Buffet
Camille Buffet
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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selection. Of the 34 samples included, 21 were from metastatic neck lymph nodes and 13 from metastatic masses, including 12 thyroid bed recurrences and 1 muscle metastasis. One patient was submitted to the sampling of two different lesions: one
Camille Buffet
Camille Buffet
Department of Thyroid Pathologies and Endocrine Tumors, AP-HP, Pitié-Salpêtrière Hospital, Groupe de Recherche Clinique n°16 Tumeurs Thyroïdiennes, Sorbonne Université, Paris, France
UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France
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UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France
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Sophie Leboulleux
Sophie Leboulleux
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institut, Villejuif, France
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Françoise Kraeber-Bodéré
Françoise Kraeber-Bodéré
Nuclear Medicine Department, Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA, Nantes, France
CHU Nantes/ICO, Saint-Herblain, France
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CHU Nantes/ICO, Saint-Herblain, France
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Caroline Bodet-Milin
Caroline Bodet-Milin
Nuclear Medicine Department, Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA, Nantes, France
CHU Nantes/ICO, Saint-Herblain, France
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CHU Nantes/ICO, Saint-Herblain, France
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Laure Cabanes
Laure Cabanes
Department of Cardiology, APHP, Cochin Hospital, Paris, France
Université de Paris, Paris, France
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Université de Paris, Paris, France
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Anthony Dohan
Anthony Dohan
Radiology Department, Université de Paris, Paris, France
Department of Radiology, AP-HP, Hôpital Cochin, Paris, France
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Department of Radiology, AP-HP, Hôpital Cochin, Paris, France
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Pascal Leprince
Pascal Leprince
Department of Thoracic and Cardiovascular Surgery, Sorbonne Université, AP-HP, Pitié-Salpêtrière Hospital, Paris, France
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Martin Schlumberger
Martin Schlumberger
UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institute, Villejuif, France
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Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institute, Villejuif, France
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Olivier Huillard
Olivier Huillard
Université de Paris, Sorbonne Paris Cité, Paris, France
Department of Medical Oncology, AP-HP, Hôpital Cochin, Paris, France
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Department of Medical Oncology, AP-HP, Hôpital Cochin, Paris, France
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Lionel Groussin
Lionel Groussin
INSERM Unité 1016, CNRS UMR 8104, Institut Cochin, Paris, France
Université de Paris, Paris, France
Department of Endocrinology, AP-HP, Hôpital Cochin, Paris, France
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Université de Paris, Paris, France
Department of Endocrinology, AP-HP, Hôpital Cochin, Paris, France
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unfavorable benefit-risk balance. Vandetanib (300 mg/day) was initiated, and a partial regression of the cardiac metastasis was observed (−30% in 8 months) and a decrease in cervical lymph node and lung metastases. Vandetanib dosage reduction was necessary
Laura Agate
Laura Agate
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Francesca Bianchi
Francesca Bianchi
Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy
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Federica Brozzi
Federica Brozzi
Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy
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Pierina Santini
Pierina Santini
Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Valeria Bottici
Valeria Bottici
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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David Viola
David Viola
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Loredana Lorusso
Loredana Lorusso
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Paolo Vitti
Paolo Vitti
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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by fine-needle aspiration cytology. Therefore, only 6/545 (1.1%) cases (3 LR [0.87%] and 3 IR [1.5%]) showed metastases (1 cervical and 1 mediastinal lymph node, 3 lung and 1 bone metastatic lesions) documented by ptWBS only. None of the patients with
Pedro Marques
Pedro Marques
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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Maria João Bugalho
Maria João Bugalho
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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Surg Oncol 2007;95:555-560. 10.1002/jso.20746 17226813 11 Chow SM, Law SC, Chan JK, Au SK, Yan S, Law WH: Papillary microcarcinoma of the thyroid - prognostic significance of lymph node metastasis and multifocality. Cancer 2003;98:31-40. 10
Joachim N Nilsson
Joachim N Nilsson
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
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Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
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Jonathan Siikanen
Jonathan Siikanen
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Vincenzo Condello
Vincenzo Condello
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Kenbugul Jatta
Kenbugul Jatta
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Ravi Saini
Ravi Saini
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Christel Hedman
Christel Hedman
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Stockholms Sjukhem Foundation's Research and Development Department, Stockholm, Sweden
Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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Stockholms Sjukhem Foundation's Research and Development Department, Stockholm, Sweden
Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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Catharina Ihre Lundgren
Catharina Ihre Lundgren
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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C Christofer Juhlin
C Christofer Juhlin
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Introduction Differentiated thyroid cancer is treated with surgery, and in cases of larger tumours or cervical lymph node metastases, additional hormone suppression and radioiodine therapy are given. Successful radioiodine therapy requires
Chitra Choudhary
Chitra Choudhary
Department of Endocrinology, Medstar Washington Hospital Center, Washington, D.C., USA
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Leonard Wartofsky
Leonard Wartofsky
Department of Endocrinology, Medstar Washington Hospital Center, Washington, D.C., USA
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Eshetu Tefera
Eshetu Tefera
MedStar Health Research Institute, Washington, D.C., USA
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Kenneth D. Burman
Kenneth D. Burman
Department of Endocrinology, Medstar Washington Hospital Center, Washington, D.C., USA
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and are usually accompanied by increases in serum Tg levels [ 11 ]. Suspicious cervical lymph nodes more than 5-8 mm in their smallest dimension should undergo fine-needle aspiration cytology while cervical lymph nodes less than 5-8 mm in the largest
