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José I. López Department of Pathology, Cruces University Hospital, BioCruces Research Institute, University of the Basque Country, Barakaldo

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Rosa Zabala Department of Radiology, Basurto University Hospital, University of the Basque Country, Bilbao, Spain

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José Luís del Cura Department of Radiology, Basurto University Hospital, University of the Basque Country, Bilbao, Spain

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sensitivity and specificity of the technique [ 4 ], and makes it possible to take samples of the solid areas in cystic lesions. Despite fine-needle aspiration cytology (FNAC) being almost universally used to take thyroid samples and, accordingly, there being

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Eun Kyung Jang Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Dong Eun Song Departments of Pathology, University of Ulsan College of Medicine, Seoul, South Korea

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Gyungyub Gong Departments of Pathology, University of Ulsan College of Medicine, Seoul, South Korea

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Jung Hwan Baek Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

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Yun Mi Choi Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Min Ji Jeon Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Ji Min Han Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Won Gu Kim Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Tae Yong Kim Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Young Kee Shong Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Won Bae Kim Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Introduction Fine needle aspiration (FNA) is a rapid, cost-effective, and safe test, which is widely used for the diagnosis of thyroid nodules [ 1 ]. The positive predictive value of a malignant FNA cytology (FNAC) result is 97-99% according

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Mathieu Bergeron Department of Otolaryngology - Head and Neck Surgery, Laval University, Quebec, Que., Canada

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Danielle Beaudoin Enfant-Jésus Hospital, Quebec, Que., Canada

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What Is Known about This Topic So Far? • Although many authors recommend a core-needle biopsy as an alternative modality in cases of inconclusive cytology with fine-needle aspiration for thyroid nodule, it is not in the American Thyroid

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Maria Mavromati Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Verdiana Caironi Department of Internal Medicine, Lugano Regional Hospital, Ente Ospedaliero Cantonale, Via Tesserete Lugano, Switzerland

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Essia Saiji Department of Pathology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Maria-Isabel Vargas Department of Neuroradiology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Shahan Momjian Department of Neurosurgery, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Stephanie Andrade-Lopes Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

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Capucine Gubert Department of Internal Medicine, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

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Marco Stefano Demarchi Department of Thoracic and Endocrine Surgery, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

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Ismini Mainta Department of Nuclear Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

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François R Jornayvaz Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Kaveh Samii Department of Hematology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Grégoire Stalder Service and Central Laboratory of Hematology, Lausanne University Hospital, rue du Bugnon Lausanne, Switzerland.
Service of Hematology and Laboratory of Hematology, Institut Central des Hôpitaux, Hôpital du Valais, Av. du Grand-Champsec, Sion, Switzerland

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Sophie Leboulleux Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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, 3 , 4 , 5 , 6 , 7 ). Thyroid ultrasound-guided fine needle aspiration cytology (FNAC) can be a noninvasive and useful tool to confirm the diagnosis and prevent unnecessary transcranial biopsy ( 3 , 8 ). Here we present the case of a young

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L. Leenhardt Department of Nuclear Medicine, Pitié Salpêtrière Hospital, Cancer Institute, Pierre et Marie Curie University, Paris, France

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M.F. Erdogan Department of Endocrinology and Metabolism, University of Ankara School of Medicine, İbni Sina Hastanesi, Ankara, Turkey

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L. Hegedus Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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S.J. Mandel Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa., USA

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R. Paschke Department of Endocrinology, University of Leipzig, Leipzig, Germany

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T. Rago Endocrine Unit 1, Department of Internal Medicine, Ospedale Cisanello, University of Pisa, Pisa, Italy

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G. Russ Department of Nuclear Medicine, Pitié Salpêtrière Hospital, Cancer Institute, Pierre et Marie Curie University, Paris, France

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are the standards for US examination, US-guided fine-needle aspiration (US-FNA) techniques, and reports? - Can US differentiate between benign and pathological cervical LN and lesions in the thyroid bed? - When should neck US be performed? - What

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Meenu Gill Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Ashima Batra Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Ashok Sangwaiya Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Samta Shakya General Hospital, Sirsa, India

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Sumiti Gupta Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Rajeev Sen Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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cervical lymph node obtained during fine-needle aspiration revealed a similar appearance with a predominant cell population of small- to medium-sized cells revealing paracentral to eccentric nuclei with clock-face chromatin and abundant sky-blue cytoplasm

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Yalin Iscan Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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Ismail Cem Sormaz Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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Fatih Tunca Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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Yasemin Giles Senyurek Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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ultrasonography (US) and the widespread use of fine-needle aspiration biopsy (FNAB) provided to identify PMC preoperatively [ 1 , 3 ]. In autopsy studies, the pathological detection rate of clinically occult papillary carcinoma has been in the range of 5.6 to

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Marco Marino Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Center for Genomic Research, Italy

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Maria Laura Monzani Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Giulia Brigante Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Katia Cioni Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Bruno Madeo Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Daniele Santi Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Antonino Maiorana Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Italy

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Stefania Bettelli Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Italy

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Valeria Moriondo Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Center for Genomic Research, Italy

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Elisa Pignatti Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Center for Genomic Research, Italy

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Lara Bonacini Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Cesare Carani Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy

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Vincenzo Rochira Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Manuela Simoni Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Center for Genomic Research, Italy
Azienda USL of Modena, Modena, Italy

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considered a diagnostic marker of PTC [ 1 ]. The wide clinical use of ultrasound (US) [ 5 ] allows detecting an increasing number of nodules that often require fine needle aspiration biopsy (FNAB) for ruling out thyroid cancer [ 6 ]. As the diagnostic value

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Sravanthi Nagavalli Division of Endocrinology and Metabolism, Torrance, CA, USA

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Marelle Yehuda Division of Endocrinology and Metabolism, Torrance, CA, USA

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Laron W. McPhaul Department of Pathology and Laboratory Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA

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Andrew G. Gianoukakis Division of Endocrinology and Metabolism, Torrance, CA, USA

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What Is Known about This Topic? • Cervical schwannomas can mimic thyroid nodules and are historically difficult to diagnosis preoperatively due to the low diagnostic yield of fine needle aspiration and their appearance as hypoechoic lesions on

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Berna Evranos Ogmen Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey

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Cevdet Aydin Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey

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Ibrahim Kilinc Department of General Surgery, Ankara Bilkent City Hospital, Ankara, Turkey

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Aysegul Aksoy Altinboga Department of Pathology, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey

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Reyhan Ersoy Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey

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Bekir Cakir Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey

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) or other radiological modalities ranges widely from 20 to 76% [ 3 , 4 ]. Fine-needle aspiration biopsy (FNAB) is the optimal procedure for preoperative discrimination of benign from malignant nodules [ 5 , 6 ]. The Bethesda System for Reporting

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