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Adile Begüm Bahçecioğlu Department of Endocrinology and Metabolism, Ankara University, School of Medicine, Ankara, Turkey

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Alptekin Gürsoy Department of Endocrinology and Metabolism, Ankara Guven Hospital, Ankara, Turkey

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Serpil Dizbay Sak Department of Pathology, Ankara University, School of Medicine Ankara, Turkey

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Seyfettin Ilgan Department of Nuclear Medicine, Ankara Guven Hospital, Ankara, Turkey

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Banu Bilezikçi Department of Pathology, Ankara Guven Hospital, Ankara, Turkey

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Murat Faik Erdoğan Department of Endocrinology and Metabolism, Ankara University, School of Medicine, Ankara, Turkey

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Introduction Ultrasonographic (US) echogenic microfoci (EMF) are frequently seen in papillary thyroid carcinoma (PTC). European Thyroid Association, the American College of Radiology (ACR), and the Korean Society of Thyroid Radiology classify

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-23-0108
Volume/Issue:
Volume 12: Issue 6
Open access
Amanda La Greca Endocrinology Service, Department of Medicine, New York, N.Y., USA

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Bin Xu Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill-Cornell College of Medicine, New York, N.Y., USA

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Ronald Ghossein Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill-Cornell College of Medicine, New York, N.Y., USA

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R. Michael Tuttle Endocrinology Service, Department of Medicine, New York, N.Y., USA

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Mona M. Sabra Endocrinology Service, Department of Medicine, New York, N.Y., USA

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Introduction Multifocal involvement of the thyroid gland is a well-recognized feature of papillary carcinoma. The reported frequency is about 20%, with wide variations depending on the extent of the sampling and reporting by the pathologist

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000448752
Volume/Issue:
Volume 6: Issue 1
Free access
Eun Kyung Jang Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Dong Eun Song Departments of Pathology, University of Ulsan College of Medicine, Seoul, South Korea

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Gyungyub Gong Departments of Pathology, University of Ulsan College of Medicine, Seoul, South Korea

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Jung Hwan Baek Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

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Yun Mi Choi Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Min Ji Jeon Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Ji Min Han Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Won Gu Kim Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Tae Yong Kim Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Young Kee Shong Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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Won Bae Kim Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

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-10% [ 3 , 4 , 5 ]. It is very rare to have a result of no evidence of malignancy by histological evaluation of the thyroid in patients with a preoperative cytological diagnosis of papillary thyroid carcinoma (PTC) [ 6 , 7 ]. One report noted disappearing

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000353624
Volume/Issue:
Volume 2: Issue 3
Free access
Ian D Hay Department of Medicine 1, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Suneetha Kaggal Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Geoffrey B Thompson Department of Surgery, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Introduction Adults with low-risk ( 1 ) papillary thyroid carcinoma (PTC) represent the commonest endocrine malignancy ( 2 ). In 2017, Pontius and colleagues ( 3 ) demonstrated, in a study of 244,040 PTC patients managed in USA during 2004

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-22-0084
Volume/Issue:
Volume 11: Issue 4
Open access
Markus Eszlinger Department of Oncology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada, and Institute of Pathology, University Hospital Halle, Halle, Germany

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Alexandra Stephenson Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada

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Shideh Mirhadi Program in Cell Biology, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada

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Konrad Patyra Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland

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Michael F Moran Program in Cell Biology, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada

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Moosa Khalil Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Jukka Kero Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
Department of Pediatrics, Turku University Hospital, Turku, Finland

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Ralf Paschke Department of Oncology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada, and Institute of Pathology, University Hospital Halle, Halle, Germany
Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada

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-dependent compensatory mechanisms ( 11 ). However, most interestingly, our data strongly suggest that a permanently active TSHR can lead to the malignant transformation of thyrocytes. After 12 months, papillary thyroid carcinoma (PTC) occurred in both heterozygous (HEZ

Article Type:
Research Article
Collections:
Thyroid cancer - basic and translational
DOI:
https://doi.org/10.1530/ETJ-23-0049
Volume/Issue:
Volume 12: Issue 6
Open access
Pedro Weslley Souza Rosario Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Gabriela Franco Mourão Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Pedro Henrique Lopes Oliveira Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Tulio Henrique Silva Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Introduction Patients with small papillary thyroid carcinomas (PTC) can currently be maintained under active surveillance (AS) instead of being submitted to immediate surgery [ 1 - 5 ]. This management is accepted for cases in which the risk

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000490701
Volume/Issue:
Volume 7: Issue 5
Free access
Eijun Nishihara Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yoshitaka Hobo ASKA Pharmamedical Co., Ltd. Fujisawa, Japan

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Akira Miyauchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yasuhiro Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Miyoko Higuchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuyoshi Hirokawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuru Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Shuji Fukata Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsushige Nishikawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Takashi Akamizu Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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measurement on structural recurrence in TgAb-positive patients with papillary thyroid carcinoma (PTC), we compared the Tg values of our Tg-LC-MS/MS with a commercially available electrochemiluminescence immunoassay for Tg (Tg-ECLIA). Furthermore, we elucidated

Article Type:
Research Article
Collections:
Thyroid function tests
DOI:
https://doi.org/10.1530/ETJ-21-0041
Volume/Issue:
Volume 11: Issue 1
Open access
Marko Stojanović Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Sandra Pekić Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Mirjana Doknić Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Dragana Miljić Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Slavica Ćirić Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Aleksandar Diklić Faculty of Medicine, University of Belgrade
Endocrine Surgery Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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Svetislav Tatić Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia

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Miloje Joksimović Clinic for Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia

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Emilija Manojlović-Gačić Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia

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Milica Skender-Gazibara Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia

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Vera Popović Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia

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insipidus or ophthalmoplegia indicate a metastatic nature of the lesion, particularly in the presence of primary malignancy. Papillary thyroid carcinoma (PTC) rarely metastasizes to the central nervous system. What This Case Report Adds • This case

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000343910
Volume/Issue:
Volume 1: Issue 4
Free access
Akira Miyauchi Departments of Surgery, Kuma Hospital, Kobe, Japan

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Takumi Kudo Departments of Internal Medicine, Kuma Hospital, Kobe, Japan

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Mitsuyoshi Hirokawa Departments of Pathology, Kuma Hospital, Kobe, Japan

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Yasuhiro Ito Departments of Surgery, Kuma Hospital, Kobe, Japan

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Minoru Kihara Departments of Surgery, Kuma Hospital, Kobe, Japan

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Takuya Higashiyama Departments of Surgery, Kuma Hospital, Kobe, Japan

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Tomonori Yabuta Departments of Surgery, Kuma Hospital, Kobe, Japan

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Hiroo Masuoka Departments of Surgery, Kuma Hospital, Kobe, Japan

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Hisakazu Shindo Departments of Surgery, Kuma Hospital, Kobe, Japan

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Kaoru Kobayashi Departments of Surgery, Kuma Hospital, Kobe, Japan

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Akihiro Miya Departments of Surgery, Kuma Hospital, Kobe, Japan

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Introduction Thyroid cancer is the most common malignancy in the endocrine organs. Papillary thyroid carcinoma is the representative pathological type, constituting about 90% of thyroid cancers. Papillary carcinoma generally shows an indolent

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000347148
Volume/Issue:
Volume 2: Issue 1
Free access
Sang-Hyeon Ju Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea

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Yong Bae Ji Department of Otolaryngology–Head and Neck Surgery, Hanyang University College of Medicine, Seoul, Republic of Korea

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Minchul Song Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea

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Joung Youl Lim Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea

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Da Beom Heo Department of Otorhinolaryngology–Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea

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Min-Gyu Kim Department of Otorhinolaryngology–Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea

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Jae Won Chang Department of Otorhinolaryngology–Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea
Department of Otorhinolaryngology–Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea

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Ho-Ryun Won Department of Otorhinolaryngology–Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Department of Otorhinolaryngology–Head and Neck Surgery, Chungnam National University Sejong Hospital, Sejong, Republic of Korea

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Yea Eun Kang Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea

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Eu Jeong Ku Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea

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Mijin Kim Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea

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Eun Kyung Lee Department of Internal Medicine, Center for Thyroid Cancer, National Cancer Center, Goyang-si, Republic of Korea

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June Young Choi Department of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea

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Hyeong Won Yu Department of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea

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Young Joo Park Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

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Jun-Ho Choe Division of Endocrine Surgery, Department of Surgery, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea

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Bon Seok Koo Department of Otorhinolaryngology–Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea
Department of Otorhinolaryngology–Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea

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the MASTER study group †
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the MASTER study group

.6–4.8% between 2003 and 2019 ( 4 ). Consequently, given the resulting prevalence of low-risk papillary thyroid carcinoma (PTC) patients and the burden posed by the potential complications, active surveillance (AS) has received increased attention ( 6 , 7

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-23-0258
Volume/Issue:
Volume 13: Issue 2
Open access