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Line Tang Møllehave Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark

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Allan Linneberg Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark

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Tea Skaaby Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark

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Nils Knudsen Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Copenhagen, Denmark

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Lars Ehlers Danish Center for Healthcare Improvements, Department of Business and Management, Aalborg University, Aalborg, Denmark

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Torben Jørgensen Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Faculty of Medicine, Aalborg University, Aalborg, Denmark

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Betina Heinsbæk Thuesen Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark

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changes in thyroid diseases after IF [ 4 ]. Therefore, changes in costs were assessed combined and by region. Iodine Fortification Before 1998 IF was prohibited in Denmark. From 1998 voluntary IF with 8 ppm of salt was endorsed but proved

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Line Tang Møllehave Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Nils Knudsen Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Denmark

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Allan Linneberg Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Inge Bülow Pedersen Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark

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Gitte Ravn-Haren Research Group for Risk Benefit, National Food Institute, Technical University of Denmark, Lyngby, Denmark

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Anja Lykke Madsen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Allan Carlé Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark

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Charlotte Cerqueira The Danish Clinical Quality Program – National Clinical Registries (RKKP), Denmark

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Anne Krejbjerg Department of Oncology, Aalborg University Hospital, Aalborg, Denmark

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Lone Banke Rasmussen Independent researcher, Klemensker, Denmark

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Lars Ovesen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Hans Perrild Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Denmark

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Lena Bjergved Sigurd Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark

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Betina Heinsbæk Thuesen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Pernille Vejbjerg Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Torben Jørgensen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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group was established to evaluate the iodine situation in Denmark and possible actions. It concluded that Denmark was iodine deficient and proposed a cautious fortification of salt ( 16 ). The Danish Food and Veterinary Administration introduced IF with

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John H. Lazarus Thyroid Research Group, Institute of Molecular and Experimental Medicine, Cardiff University, University Hospital of Wales, Cardiff, UK

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% having a UI of <50 µg/l [ 3 ]. In pregnancy, the median UI should be at least 150 µg/l, on account of increased iodine requirements during gestation and lactation [ 9 ]. The results of the questionnaire showed, firstly, that salt iodisation is mandatory

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Bing Han Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

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Chi Chen Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

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Yi Chen Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

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Ningjian Wang Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

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Jie Yu Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

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Jing Cheng Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

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Yingchao Chen Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

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Chunfang Zhu Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

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Yingli Lu Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

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iodine intake can cause goiter, while more than adequate iodine intake can also result in thyroid disorders. In 1996, a mandatory universal salt iodization program was performed. Since then, China has eliminated iodine deficiency disorders, and iodine

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Juan Bernal
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Maria Jesús Obregon
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Pilar S. Santisteban
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of congenital hypothyroidism and was instrumental in the introduction of iodized salt. She was very active and influential in Spanish and international scientific societies. She was one of the founders of the European Thyroid Association, in 1967

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Yi Pan Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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Kathleen L. Caldwell Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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Yan Li Joint Program in Survey Methodology, University of Maryland, College Park, Md., USA

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Samuel P. Caudill Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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Mary E. Mortensen Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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Amir Makhmudov Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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Robert L. Jones Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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well as fruits, vegetables and iodized salt. When iodine intake is inadequate, thyroid enlargement, termed goiter, can result. Historically, endemic goiter, which resulted from iodine deficiency, was described as ‘one of the most important and

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Wenxing Guo The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Long Tan The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Shuyao Dong The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Ya Jin The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Mei Zhu The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China

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Hongyan Wei The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China

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Yanting Chen The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Lili Fan The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Cong Du The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Wanqi Zhang The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China
The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China
Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China

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-sufficient populations. Chinese goitre standard published in 2007 [ 4 ] was based on European data from 1993 [ 5 ]. As the universal salt iodization programme has been mandatory since 1994 in China, iodine status has been greatly improved [ 6 ]. A previous study showed

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Roberto Negro Division of Endocrinology, “V. Fazzi” Hospital, Lecce

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Roberto Attanasio Endocrinology Service, Galeazzi Institute IRCCS, Milan

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Franco Grimaldi Endocrinology and Metabolic Disease Unit, Azienda Ospedaliero-Universitaria “S. Maria della Misericordia,” Udine

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Andrea Frasoldati Division of Endocrinology, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia

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Rinaldo Guglielmi Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Enrico Papini Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Benign Nodule For a 25-year-old patient with a nodular goiter, benign FNA, and no compressive symptoms, 54.7% suggest iodized salt, 24.4% levothyroxine treatment aiming at a low-normal thyroid-stimulating hormone, and 18.6% advise avoidance of iodine

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Stine Linding Andersen Department of Endocrinology, Aalborg University Hospital, Aalborg

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Jørn Olsen Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark

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Chun Sen Wu Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark

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Peter Laurberg Department of Endocrinology, Aalborg University Hospital, Aalborg

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Great Belt). The mandatory iodine fortification of salt was introduced in the year 2000 and had increased urinary iodine to a lower recommended level in 2004-2005 [ 21 ]. From the DNHR, we obtained information on maternal first-time diagnosis of

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Françoise Brucker-Davis Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Patricia Panaïa-Ferrari Departments of Biochemistry, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Jocelyn Gal Departments of Biostatistics, CHU de Nice, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Patrick Fénichel Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Sylvie Hiéronimus Department of Endocrinology, Diabetology and Reproductive Medicine

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. 84% of women who knew what type of salt they were taking reported consumption of iodinated salt, with no significant difference between the two groups. Table 1 Baseline characteristics of the 86 women followed until delivery

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