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Haiyang Zhang
Haiyang Zhang
Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Shuo Wu
Shuo Wu
Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Shuyu Hu
Shuyu Hu
Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Xianqun Fan
Xianqun Fan
Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Xuefei Song
Xuefei Song
Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Tienan Feng
Tienan Feng
Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Huifang Zhou
Huifang Zhou
Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
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endeavors in this field. Given the current circumstances, the objective of this study was to conduct a comprehensive systematic review and meta-analysis to examine the effectiveness of existing prediction models in determining the response of patients with
Alessia Cozzolino
Alessia Cozzolino
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Tiziana Filardi
Tiziana Filardi
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Ilaria Simonelli
Ilaria Simonelli
Service of Medical Statistics and Information Technology, Fatebenefratelli Foundation for Health Research and Education, Rome, Italy
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
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Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
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Giorgio Grani
Giorgio Grani
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Camilla Virili
Camilla Virili
Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy
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Ilaria Stramazzo
Ilaria Stramazzo
Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy
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Maria Giulia Santaguida
Maria Giulia Santaguida
Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy
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Pietro Locantore
Pietro Locantore
Endocrinology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
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Massimo Maurici
Massimo Maurici
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
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Daniele Gianfrilli
Daniele Gianfrilli
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Andrea M Isidori
Andrea M Isidori
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Carlotta Pozza
Carlotta Pozza
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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on behalf of TALENT Group
on behalf of TALENT Group
on behalf of TALENT Group
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manuscript is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines ( 9 ). Eligibility criteria and study selection Observational/cohort/diagnostic accuracy studies dealing with thyroid nodule
Liliana Ribeiro Santos
Liliana Ribeiro Santos
Internal Medicine Department, Hospital of Santa Maria, Lisbon, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
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Inês Vasconcelos Bessa
Inês Vasconcelos Bessa
Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
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Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
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Adriana Gaspar da Rocha
Adriana Gaspar da Rocha
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
Public Health Unit, ACES Baixo Mondego, Coimbra, Portugal
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Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
Public Health Unit, ACES Baixo Mondego, Coimbra, Portugal
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Celestino Neves
Celestino Neves
Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Department of Endocrinology, Hospital University Centre of São João, Porto, Portugal
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Department of Endocrinology, Hospital University Centre of São João, Porto, Portugal
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Cláudia Freitas
Cláudia Freitas
Department of Endocrinology, Hospital University Centre of Porto, Porto, Portugal
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Paula Soares
Paula Soares
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto, Porto, Portugal
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Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto, Porto, Portugal
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effectively ( 34 ). On the other hand, a subsequent systematic review and meta-analysis, including trials in chronic autoimmune thyroiditis concluded that the evidence in clinical parameters, such as effects of Se-Su on disease remission, progression, lowered
Rémy Louvel
Rémy Louvel
Head and Neck Surgical Oncology Department, Institut Curie, PSL University, Paris, France
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Nathalie Badois
Nathalie Badois
Head and Neck Surgical Oncology Department, Institut Curie, PSL University, Paris, France
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Jerzy Klijanienko
Jerzy Klijanienko
Pathology Department, Institut Curie, PSL University, Paris, France
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Ségolène Hescot
Ségolène Hescot
Medical Oncology Department, Institut Curie, PSL University, Paris, France
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Caroline Hoffmann
Caroline Hoffmann
Head and Neck Surgical Oncology Department, Institut Curie, PSL University, Paris, France
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the manuscript. References 1 de Vries LH Aykan D Lodewijk L Damen JAA Borel Rinkes IHM Vriens MR . Outcomes of minimally invasive thyroid surgery – a systematic review and meta-analysis . Frontiers in Endocrinology 2021 12
Emna Jelloul
Emna Jelloul
Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium
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Georgiana Sitoris
Georgiana Sitoris
Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium
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Flora Veltri
Flora Veltri
Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium
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Pierre Kleynen
Pierre Kleynen
Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium
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Serge Rozenberg
Serge Rozenberg
Departement of Gynecology and Obstetrics, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium
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Kris G Poppe
Kris G Poppe
Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium
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meta-analysis . Lancet. Diabetes and Endocrinology 2022 10 243 – 252 . ( https://doi.org/10.1016/S2213-8587(2200007-9 ) 8 Chiu G Zhang X Zhao E & Liu B . Maternal thyroid disease and neonatal low birth weight: a systematic review and meta-analysis
Esther J. van Zuuren
Esther J. van Zuuren
Departments of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands
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Amira Y. Albusta
Amira Y. Albusta
College of Medicine, AMA International University of Bahrain, Manama
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Zbys Fedorowicz
Zbys Fedorowicz
UKCC (Bahrain Branch), The Cochrane Collaboration, Awali, Bahrain
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Ben Carter
Ben Carter
Institute of Primary Care & Public Health, Cardiff University School of Medicine, Cardiff, UK
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Hanno Pijl
Hanno Pijl
Departments of Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
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systematic review and a meta-analysis. Thyroid 2010;20:1163-1173. 10.1089/thy.2009.0351 20883174 7 Turker O, Kumanlioglu K, Karapolat I, Dogan I: Selenium treatment in autoimmune thyroiditis: 9-month follow-up with variable doses. J Endocrinol 2006
Beatrice Engelmann
Beatrice Engelmann
Interfaculty Institute for Genetics and Functional Genomics, Germany
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Julia Bischof
Julia Bischof
Interfaculty Institute for Genetics and Functional Genomics, Germany
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Anne-Luise Dirk
Anne-Luise Dirk
Experimental and Clinical Endocrinology, Med Clinic I, University of Lübeck, Lübeck, Germany
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Nele Friedrich
Nele Friedrich
Institute for Clinical Chemistry and Laboratory Medicine, Germany
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Elke Hammer
Elke Hammer
Interfaculty Institute for Genetics and Functional Genomics, Germany
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Thomas Thiele
Thomas Thiele
Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany
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Dagmar Führer
Dagmar Führer
Clinic for Endocrinology and Metabolic Disorders, University Clinics Essen, Essen, Germany
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Georg Homuth
Georg Homuth
Interfaculty Institute for Genetics and Functional Genomics, Germany
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Georg Brabant
Georg Brabant
Experimental and Clinical Endocrinology, Med Clinic I, University of Lübeck, Lübeck, Germany
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Uwe Völker
Uwe Völker
Interfaculty Institute for Genetics and Functional Genomics, Germany
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, Brandjes DP, Gerdes VE, Squizzato A: The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: a systematic review and meta-analysis. Thromb Haemost 2012;108:1077-1088. 10.1160/TH12-07-0496 23014708 3 Hooper JM, Stuijver
Ernesto Maddaloni
Ernesto Maddaloni
Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Silvia Irina Briganti
Silvia Irina Briganti
Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy
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Anna Crescenzi
Anna Crescenzi
Pathology Unit, Campus Bio-Medico University of Rome, Rome, Italy
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Giuseppina Beretta Anguissola
Giuseppina Beretta Anguissola
Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy
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Eleonora Perrella
Eleonora Perrella
Pathology Unit, Campus Bio-Medico University of Rome, Rome, Italy
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Chiara Taffon
Chiara Taffon
Pathology Unit, Campus Bio-Medico University of Rome, Rome, Italy
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Andrea Palermo
Andrea Palermo
Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy
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Silvia Manfrini
Silvia Manfrini
Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy
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Paolo Pozzilli
Paolo Pozzilli
Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy
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Angelo Lauria Pantano
Angelo Lauria Pantano
Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy
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color Doppler ultrasonography for the prediction of malignancy in follicular thyroid neoplasms: systematic review and meta-analysis . J Ultrasound Med . 2010 Mar ; 29 ( 3 ): 419 – 25 . 10.7863/jum.2010.29.3.419 20194937 0278-4297 4
Marie Alix Balay
Marie Alix Balay
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Patrick Aidan
Patrick Aidan
American Hospital of Paris, Neuilly sur Seine, France
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Marie Helene Schlageter
Marie Helene Schlageter
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Odette Georges
Odette Georges
American Hospital of Paris, Neuilly sur Seine, France
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Taly Meas
Taly Meas
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Maroun Bechara
Maroun Bechara
American Hospital of Paris, Neuilly sur Seine, France
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Marie Elisabeth Toubert
Marie Elisabeth Toubert
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Isabelle Faugeron
Isabelle Faugeron
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Herve Monpeyssen
Herve Monpeyssen
American Hospital of Paris, Neuilly sur Seine, France
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Cécile N. Chougnet
Cécile N. Chougnet
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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CKH, Tsang JS, Wong KP, Wan KY: A systematic review and meta-analysis evaluating completeness and outcomes of robotic thyroidectomy. Laryngoscope 2015; 125: 509–518. 10.1002/lary.24946 25236330 4 Lee SG, Lee J, Kim MJ, Choi JB, Kim TH, Ban EJ
Bülent Öcal
Bülent Öcal
Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
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Mehmet Hakan Korkmaz
Mehmet Hakan Korkmaz
Department of Otolaryngology, Yıldırım Beyazıt University Medical School, Ankara, Turkey
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Demet Yılmazer
Demet Yılmazer
Department of Pathology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
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Tuğba Taşkın Türkmenoğlu
Tuğba Taşkın Türkmenoğlu
Department of Pathology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
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Ömer Bayır
Ömer Bayır
Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
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Güleser Saylam
Güleser Saylam
Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
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Emel Çadallı Tatar
Emel Çadallı Tatar
Department of Otolaryngology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
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Sevilay Karahan
Sevilay Karahan
Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
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Erman Çakal
Erman Çakal
Department of Endocrinology, Ministry of Health Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
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. [ 2 ] found that a solitary nodule had a higher risk of malignancy than a nonsolitary nodule, but the risk of malignancy per patient remains the same regardless of the number of nodules. In a recent systematic review and meta-analysis, Brito et al
