Search for other papers by Kristine Z Swan in
Google Scholar
PubMed
Search for other papers by Johnson Thomas in
Google Scholar
PubMed
Search for other papers by Viveque E Nielsen in
Google Scholar
PubMed
Search for other papers by Marie Louise Jespersen in
Google Scholar
PubMed
Search for other papers by Steen J Bonnema in
Google Scholar
PubMed
Introduction Risk stratification of thyroid nodules uses ultrasound features predictive of benign or malignant disease to identify nodules that should undergo biopsy. Biopsy is an invasive procedure and may not yield a final diagnosis one out
Search for other papers by Cosimo Durante in
Google Scholar
PubMed
Search for other papers by Laszlo Hegedüs in
Google Scholar
PubMed
Search for other papers by Agnieszka Czarniecka in
Google Scholar
PubMed
Search for other papers by Ralf Paschke in
Google Scholar
PubMed
Search for other papers by Gilles Russ in
Google Scholar
PubMed
Search for other papers by Fernando Schmitt in
Google Scholar
PubMed
Search for other papers by Paula Soares in
Google Scholar
PubMed
Search for other papers by Tamas Solymosi in
Google Scholar
PubMed
Search for other papers by Enrico Papini in
Google Scholar
PubMed
Introduction A thyroid nodule is a discrete lesion within the thyroid gland that is ultrasonographically distinct from the surrounding thyroid parenchyma. With the widespread use of sensitive imaging techniques, which include neck
Search for other papers by Mathieu Bergeron in
Google Scholar
PubMed
Search for other papers by Danielle Beaudoin in
Google Scholar
PubMed
What Is Known about This Topic So Far? • Although many authors recommend a core-needle biopsy as an alternative modality in cases of inconclusive cytology with fine-needle aspiration for thyroid nodule, it is not in the American Thyroid
Search for other papers by Chantal A Lebbink in
Google Scholar
PubMed
Search for other papers by Thera P Links in
Google Scholar
PubMed
Search for other papers by Agnieszka Czarniecka in
Google Scholar
PubMed
Search for other papers by Renuka P Dias in
Google Scholar
PubMed
Search for other papers by Rossella Elisei in
Google Scholar
PubMed
Search for other papers by Louise Izatt in
Google Scholar
PubMed
Search for other papers by Heiko Krude in
Google Scholar
PubMed
Search for other papers by Kerstin Lorenz in
Google Scholar
PubMed
Search for other papers by Markus Luster in
Google Scholar
PubMed
Search for other papers by Kate Newbold in
Google Scholar
PubMed
Search for other papers by Arnoldo Piccardo in
Google Scholar
PubMed
Search for other papers by Manuel Sobrinho-Simões in
Google Scholar
PubMed
Search for other papers by Toru Takano in
Google Scholar
PubMed
Search for other papers by A S Paul van Trotsenburg in
Google Scholar
PubMed
Search for other papers by Frederik A Verburg in
Google Scholar
PubMed
Search for other papers by Hanneke M van Santen in
Google Scholar
PubMed
NTRK fusions, while mutations in BRAF, V600E, and RAS point mutations are less frequent ( 4 , 5 ). Due to these genomic differences, the utility of molecular testing on biopsies of thyroid nodules and on thyroid tissue in children may be different
Search for other papers by Chitra Choudhary in
Google Scholar
PubMed
Search for other papers by Leonard Wartofsky in
Google Scholar
PubMed
Search for other papers by Eshetu Tefera in
Google Scholar
PubMed
Search for other papers by Kenneth D. Burman in
Google Scholar
PubMed
prognostication, to provide information on the risk of recurrence and to plan the follow-up of these patients [ 1 ]. Delayed risk stratification after 6-8 months of radioiodine ablation can provide more information on the risk of recurrence. Thyroid bed nodules
Search for other papers by Rachelle P Mendoza in
Google Scholar
PubMed
Search for other papers by Richard Cody Simon in
Google Scholar
PubMed
Search for other papers by Nicole A Cipriani in
Google Scholar
PubMed
Search for other papers by Tatjana Antic in
Google Scholar
PubMed
Introduction Fine needle aspiration cytology (FNA) is widely accepted as the most accurate and cost-effective diagnostic procedure in the assessment of thyroid nodules. The Bethesda System outlines the diagnostic categories for thyroid nodules
Search for other papers by Enrico Papini in
Google Scholar
PubMed
Search for other papers by Hervé Monpeyssen in
Google Scholar
PubMed
Search for other papers by Andrea Frasoldati in
Google Scholar
PubMed
Search for other papers by Laszlo Hegedüs in
Google Scholar
PubMed
Scope of the Document Thyroid nodules are common in the adult population with a prevalence at ultrasound (US) examination of up to 50% in adult females and 30% in males [ 1 - 3 ]. Most lesions are cytologically benign and neither cause local
Search for other papers by Laszlo Hegedüs in
Google Scholar
PubMed
Search for other papers by Andrea Frasoldati in
Google Scholar
PubMed
Search for other papers by Roberto Negro in
Google Scholar
PubMed
Search for other papers by Enrico Papini in
Google Scholar
PubMed
treat thyroid cysts and benign nodules associated with symptoms of compression, and are currently routinely used in some European countries as well as in the Far East [ 1 , 3 , 7 ]. Recently, TA of thyroid tissue, that is destruction by heating and
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
Search for other papers by Ernesto Maddaloni in
Google Scholar
PubMed
Search for other papers by Silvia Irina Briganti in
Google Scholar
PubMed
Search for other papers by Anna Crescenzi in
Google Scholar
PubMed
Search for other papers by Giuseppina Beretta Anguissola in
Google Scholar
PubMed
Search for other papers by Eleonora Perrella in
Google Scholar
PubMed
Search for other papers by Chiara Taffon in
Google Scholar
PubMed
Search for other papers by Andrea Palermo in
Google Scholar
PubMed
Search for other papers by Silvia Manfrini in
Google Scholar
PubMed
Search for other papers by Paolo Pozzilli in
Google Scholar
PubMed
Search for other papers by Angelo Lauria Pantano in
Google Scholar
PubMed
Introduction Thyroid nodules affect up to two-thirds of the general population, with 7–15% being thyroid cancers. The number of thyroid nodules’ diagnoses is constantly increasing due to the fortuitous findings during imaging procedures
Search for other papers by Bülent Öcal in
Google Scholar
PubMed
Search for other papers by Mehmet Hakan Korkmaz in
Google Scholar
PubMed
Search for other papers by Demet Yılmazer in
Google Scholar
PubMed
Search for other papers by Tuğba Taşkın Türkmenoğlu in
Google Scholar
PubMed
Search for other papers by Ömer Bayır in
Google Scholar
PubMed
Search for other papers by Güleser Saylam in
Google Scholar
PubMed
Search for other papers by Emel Çadallı Tatar in
Google Scholar
PubMed
Search for other papers by Sevilay Karahan in
Google Scholar
PubMed
Search for other papers by Erman Çakal in
Google Scholar
PubMed
Introduction The estimated prevalence of thyroid nodules in an adult population is 4–7% by palpation and 10–41% by ultrasound (US) scanning [ 1 , 2 ]. The overall malignancy risk, regardless of nodule size, is < 10%, and even smaller nodules