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Kathrin Engels Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany

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Helena Rakov Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany

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Denise Zwanziger Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany

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Lars C. Moeller Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany

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Georg Homuth Department of Functional Genomics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

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Josef Köhrle Institute of Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Klaudia Brix Department of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany

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Dagmar Führer Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany

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were studied under conditions of euthyroidism and chronic hyperthyroidism. In addition to serum concentrations, total thyroxine (TT 4 ), free thyroxine (fT 4 ) and free triiodothyronine (fT 3 ), TH transporter mRNA levels and expression of TH

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000381020
Volume/Issue:
Volume 4: Issue 1_Suppl
Free access
N. Papanikolaou Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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P. Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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reported to be between 60 and 80% [ 2 , 3 ]. • Thyrotoxic myopathy usually resolves after the restoration of euthyroidism [ 4 , 5 ]. What Does This Case Report Add? • It highlights that myalgia can rarely be the presenting symptom of

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000343826
Volume/Issue:
Volume 1: Issue 4
Free access
Sangeetha Sirigiri Departments of Endocrinology, Tirupati, India

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Suresh Vaikkakara Departments of Endocrinology, Tirupati, India

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Alok Sachan Departments of Endocrinology, Tirupati, India

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P.V.L.N. Srinivasarao Departments of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, India

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Sunil Epuri Departments of Endocrinology, Tirupati, India

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Sailaja Anantarapu Departments of Endocrinology, Tirupati, India

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Arun Mukka Departments of Endocrinology, Tirupati, India

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Srinivasa Rao Chokkapu Departments of Endocrinology, Tirupati, India

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Ashok Venkatanarasu Departments of Endocrinology, Tirupati, India

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Ravi Poojari Departments of Endocrinology, Tirupati, India

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percentage of body fat [ 7 ] and truncal distribution of fat has been reported in hypothyroidism in comparison to matched euthyroid controls [ 8 , 9 ]. Such a body composition is also known to be associated with the metabolic syndrome [ 10 ], which in turn is

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000448889
Volume/Issue:
Volume 5: Issue 4
Free access

2020 research and innovation action EUthyroid (Project ID: 634453, http://euthyroid.eu/) are increasingly concerned about the deteriorating commitment of policymakers to address public health strategies against IDD in the European populations

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000490143
Volume/Issue:
Volume 7: Issue 4
Free access
Ilaria Muller Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom

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Lucy S. Kilburn Institute of Cancer Research – Clinical Trials & Statistics Unit (ICR-CTSU), London, United Kingdom

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Peter N. Taylor Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom

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Peter J. Barrett-Lee Academic Breast Department, Velindre Cancer Centre, Cardiff, United Kingdom

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Judith M. Bliss Institute of Cancer Research – Clinical Trials & Statistics Unit (ICR-CTSU), London, United Kingdom

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Paul Ellis Guy’s Hospital and King’s College, London, United Kingdom

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Marian E. Ludgate Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom

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Colin M. Dayan Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom

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variable: euthyroid (FT4 and TSH within the normal ranges), hypothyroid (FT4 <9.0 pmol/L and/or TSH >4.40 mIU/L), and hyperthyroid (FT4 >19.1 pmol/L and/or TSH <0.3 mIU/L). Statistical Analysis According to TPOAb prevalence in age-matched females of

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000460246
Volume/Issue:
Volume 6: Issue 4
Free access
Hicham Benabdelkamel Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Malak A Jaber Pharmaceutical Medicinal Chemistry & Pharmacognosy, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan

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Lina A Dahabiyeh Division of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman, Jordan

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Afshan Masood Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Reem H Almalki Metabolomics Section, Department of Clinical Genomics, Center for Genome Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia

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Mohthash Musambil Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Anas M Abdel Rahman Metabolomics Section, Department of Clinical Genomics, Center for Genome Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Department of Medicine, College of Medicine and King Saud Medical City, King Saud University, Riyadh, Saudi Arabia

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Assim A Alfadda Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia
Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia

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been applied to understand the molecular mechanism in the urine of rats ( 16 ), detect metabolic changes associated with the transition from hypothyroidism to euthyroidism using NMR-based metabolomics ( 17 ), identify biomarkers to distinguish between

Article Type:
Research Article
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1530/ETJ-23-0062
Volume/Issue:
Volume 12: Issue 4
Open access
Sarah L. Lutterman Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Nitash Zwaveling-Soonawala Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Hein J. Verberne Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Frederik A. Verburg Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

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A.S. Paul van Trotsenburg Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Christiaan F. Mooij Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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was to achieve euthyroidism; hypothyroidism was considered a side effect. The current American Thyroid Association and European Thyroid Association treatment guidelines both state that in pediatric GD patients, the RAI treatment goal is to achieve

Article Type:
Systematic Review
DOI:
https://doi.org/10.1159/000517174
Volume/Issue:
Volume 10: Issue 5
Open access
Kris Poppe Endocrine Unit, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Peter Bisschop Department of Endocrinology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Laura Fugazzola Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, and Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Gesthimani Minziori Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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David Unuane Department of Internal Medicine, Endocrine Unit, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium

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Andrea Weghofer Department of Gynecological Endocrinology & Reproductive Medicine, Medical University of Vienna, Vienna, Austria

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/L, LT4 treatment increased LBR to comparable rates to those in women without elevated TSH [ 11 ]. In a recent meta-analysis investigating the impact of euthyroid TAI on ART pregnancy outcomes, no decreased LBR was observed [ 15 ]. This discrepancy with

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000512790
Volume/Issue:
Volume 9: Issue 6
Free access
Sujoy Ghosh Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Subhodip Pramanik Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Kaushik Biswas Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Kingshuk Bhattacharjee Biocon Limited, Bengaluru, India

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Rajib Sarkar School of Digestive and Liver Diseases, Kolkata, India

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Subhankar Chowdhury Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Pradip Mukhopadhyay Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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[ 2 ]. However, absorption pattern is different in euthyroid subjects as compared to hypothyroid subjects. Benvenga et al.[ 3 ] reported that absorption peak of levothyroxine was more than 70%, which occurs at around 2 h in euthyroid subjects, 3 h in

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000504218
Volume/Issue:
Volume 9: Issue 1
Free access
David Shaki Pediatric Endocrinology Unit, Saban Pediatric Medical Center for Israel, Beer Sheva, Israel
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Marina Eskin-Schwartz Genetics Institute at Soroka University Medical Center and the Morris Kahn Laboratory of Human Genetics, National Center for Rare Diseases, at the Faculty of Health Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Noam Hadar Genetics Institute at Soroka University Medical Center and the Morris Kahn Laboratory of Human Genetics, National Center for Rare Diseases, at the Faculty of Health Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Emily Bosin Endocrinology Lab, Soroka University Medical Center, Beer Sheva, Israel

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Lior Carmon Pediatric Endocrinology Unit, Saban Pediatric Medical Center for Israel, Beer Sheva, Israel
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Samuel Refetoff Departments of Medicine and Pediatrics and the Committee on Genetics, The University of Chicago, Chicago, Illinois, USA

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Eli Hershkovitz Pediatric Endocrinology Unit, Saban Pediatric Medical Center for Israel, Beer Sheva, Israel
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Ohad S Birk Genetics Institute at Soroka University Medical Center and the Morris Kahn Laboratory of Human Genetics, National Center for Rare Diseases, at the Faculty of Health Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Alon Haim Pediatric Endocrinology Unit, Saban Pediatric Medical Center for Israel, Beer Sheva, Israel
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

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immunoassay interference issues due to the existence of endogenous antibodies ( 4 , 5 ). In the current study, we describe three unrelated families of Bene Israel Indian Jewish ethnicity, with clinically euthyroid individuals having low or undetectable TSH

Article Type:
Research Article
Collections:
Hypothalamus-pituitary-thyroid axis
DOI:
https://doi.org/10.1530/ETJ-21-0072
Volume/Issue:
Volume 11: Issue 1
Open access