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]. Values are about one tenth of those at the accident of Chernobyl NPS. Figure 1 shows the total deposition of cesium-134 and cesium-137 on the ground surface throughout all of East Japan, reflecting the results of the Fourth Airborne Monitoring Survey
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, 14 ). A Chinese study of 264 sarcopenic patients aged 80 years and older found that in a euthyroid population, those with lower levels of free triiodothyronine (FT3) had a higher risk of mortality ( 15 ). An American survey also found the association
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Objective: As thionamide is associated with various adverse effects, we reevaluated the practical efficacy of potassium iodide (KI) therapy for Graves’ hyperthyroidism (GD).
Methods: We administered KI (mainly 100 mg/day) to 324 untreated GD patients, and added methimazole (MMI) only to those remaining thyrotoxic even at 200 mg/day. When the patient became hypothyroid, MMI if taken was stopped, then levothyroxine (LT4) was added without reducing the KI dose. Radioactive iodine (RI) therapy or thyroidectomy was performed whenever required. We evaluated the early effects of KI at 2-4 weeks, and followed patients for 2 years.
Results: At 2 weeks, serum thyroid hormone decreased in all 324 patients. At 4 weeks, fT4, fT3, and both fT4 and fT3 levels became normal or low in 74.7%, 50.6%, and 50.6%, respectively. In a cross-sectional survey over 2-years, GD was well-controlled with KI or KI+LT4 (KI-effective) in >50% of patients at all time points. Among 288 patients followed for 2 years, 42.7% remained ‘KI-effective’ throughout 2 years (KI Group), 30.9% were well-controlled with additional MMI given for 1-24 months, and 26.4% were successfully treated with ablative therapy (mainly RI). Among ‘KI-effective’ patients at 4 weeks, 76.5% were classified into KI Group. No patients experienced adverse effects of KI.
Conclusion: KI therapy was useful in the treatment of GD. A sufficient dose of KI was effective in >50% of GD patients from 4 weeks to 2 years, and 42.7% (76.5% of ‘KI effective’ patients at 4 weeks) remained ‘KI-effective’ throughout 2 years.
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Hungary, Budapest in the middle of the country, and Szolnok in East Hungary) were selected to participate in the European ThyroMobil program (1994), and the survey was repeated in the same cities a decade later (2005). Thyroid ultrasound was performed in
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Japan
Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Japan
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incidences of damage to their genome, and based on data on the prevalence of clinically evident thyroid cancer, the first event of carcinogenesis was believed to occur in middle age [ 7 ]. The Fukushima Health Management Survey (FHMS) showed data
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. Table 1 Countries of the ICCIDD GN in West and Central Europe During 2013, a postal enquiry survey was performed requesting relevant information on the iodine status from all national coordinators of the ICCIDD GN in the West and Central
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is in contrast to the previous postal survey of members of the American Thyroid Association that was published in 2001 [ 30 ]. In that study, both the hypothetical patients had a higher reported TSH of 8.2 mU/l and positive autoantibodies, with 96 and
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seaweed and overcooked sea sponge [ 4 ]. A large number of studies have shown the effect of iodine supplementation on the epidemiology of goiter [ 5 , 6 , 7 ]. In two surveys conducted in Pescopagano [ 8 , 9 ], an Italian village with a previous moderate
Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
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Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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inhabitants are registered with a unique identification number [ 21 ], we randomly extracted civilians residing in the two study areas for two cross-sectional studies. For each hyperthyroid patient, we included 4 randomly selected women from two surveys, all
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Dear Editor, In the September issue of the European Thyroid Journal , Negro et al. [ 1 ] reported on a survey carried out among members of AME (Associazione Medici Endocrinologi) and AACE (American Association of Clinical Endocrinologists
