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Dorinda Mullen Department of Pathology, St. Vincent’s University Hospital, Dublin 4, Ireland

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Sarah Mullins Department of Pathology, St. Vincent’s University Hospital, Dublin 4, Ireland

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Aoife Doyle Department of Pathology, St. Vincent’s University Hospital, Dublin 4, Ireland

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Rachel K. Crowley Department of Endocrinology, St. Vincent’s University Hospital, Dublin 4, Ireland
School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland

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Stephen Skehan Department of Radiology, St. Vincent’s University Hospital, Dublin 4, Ireland
School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland

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Enda W. McDermott Department of Surgery, St. Vincent’s University Hospital, Dublin 4, Ireland
School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland

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Ruth S. Prichard Department of Surgery, St. Vincent’s University Hospital, Dublin 4, Ireland
School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland

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David Gibbons Department of Pathology, St. Vincent’s University Hospital, Dublin 4, Ireland
School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland

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Introduction Thyroid nodules are a common finding in the general population with estimates of up to 50% of the population having a sonographically detectable thyroid lesion [ 1 ]. Only 5% of these are malignant, and the use of fine needle

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000478773
Volume/Issue:
Volume 6: Issue 5
Free access
Kathrin Engels Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany

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Helena Rakov Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany

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Denise Zwanziger Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany

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Lars C. Moeller Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany

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Georg Homuth Department of Functional Genomics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

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Josef Köhrle Institute of Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Klaudia Brix Department of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany

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Dagmar Führer Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany

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Introduction Hyperthyroidism is a pathological state characterized by excessive thyroid hormone (TH) action in the body. Classical clinical features include anxiety, nervousness, tremor, weight loss and heat intolerance, which are often

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000381020
Volume/Issue:
Volume 4: Issue 1_Suppl
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Filipe Pereira Clinical and Experimental Endocrinology, Multidisciplinary Unit for Biomedical Research (UMIB), ICBAS, University of Porto, Porto

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Sofia S. Pereira Clinical and Experimental Endocrinology, Multidisciplinary Unit for Biomedical Research (UMIB), ICBAS, University of Porto, Porto
Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto

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Marta Mesquita Serviço de Anatomia Patológica, Instituto Português Oncologia de Lisboa, Francisco Gentil, Lisbon

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Tiago Morais Clinical and Experimental Endocrinology, Multidisciplinary Unit for Biomedical Research (UMIB), ICBAS, University of Porto, Porto

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Madalena M. Costa Clinical and Experimental Endocrinology, Multidisciplinary Unit for Biomedical Research (UMIB), ICBAS, University of Porto, Porto

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Pedro Quelhas Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto
Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto

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Carlos Lopes Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)
Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto

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Mariana P. Monteiro Clinical and Experimental Endocrinology, Multidisciplinary Unit for Biomedical Research (UMIB), ICBAS, University of Porto, Porto

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Valeriano Leite Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
Serviço de Endocrinologia, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisbon, Portugal

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Introduction Malignant thyroid tumors provide a good model to study the mechanisms underlying the metastatic process. The most prevalent thyroid tumors are papillary (PTC) and follicular (FTC) carcinomas. Although both originate from

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000457794
Volume/Issue:
Volume 6: Issue 2
Free access
Mathieu Bergeron Department of Otolaryngology - Head and Neck Surgery, Laval University, Quebec, Que., Canada

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Danielle Beaudoin Enfant-Jésus Hospital, Quebec, Que., Canada

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What Is Known about This Topic So Far? • Although many authors recommend a core-needle biopsy as an alternative modality in cases of inconclusive cytology with fine-needle aspiration for thyroid nodule, it is not in the American Thyroid

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000360985
Volume/Issue:
Volume 3: Issue 2
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Rania Mehanna Departments of Otolaryngology, South Infirmary Victory University Hospital, Cork, Ireland

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Matthew S. Murphy Endocrinology, South Infirmary Victory University Hospital, Cork, Ireland

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Patrick Sheahan Departments of Otolaryngology, South Infirmary Victory University Hospital, Cork, Ireland

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Introduction The thyroid tubercle of Zuckerkandl (TZ) (fig. 1 , 2 ) is an important landmark in thyroid surgery, which was first described by the Viennese anatomist, Emil Zuckerkandl, in 1902 [ 1 ]. This structure is usually present as a

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000355823
Volume/Issue:
Volume 3: Issue 1
Free access
Denise P. Carvalho Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Corinne Dupuy Université Paris-Sud, UMR 8200 CNRS, Institute Gustave Roussy, Villejuif, France

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Introduction The thyroid follicle is the functional structure responsible for thyroid hormone biosynthesis, storage and secretion (fig. 1 ). Follicular thyroid cells are polarized and specialized in the production of thyroxine (T4) and 3

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000354745
Volume/Issue:
Volume 2: Issue 3
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Peter P.A. Smyth School of Medicine, University College Dublin, Dublin, Ireland

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especially true in the first weeks of life, as the developing foetus does not develop a functioning thyroid until about 18- to 20-week gestation during which time it is totally dependent on the mother to produce thyroid hormones necessary for growth and

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000512971
Volume/Issue:
Volume 10: Issue 2
Free access
Evangelos Karvounis Department of Endocrine Surgery Center of Excellence, Euroclinic Hospital, Athens, Greece

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Ioannis Kappas Department of Endocrine Surgery Center of Excellence, Euroclinic Hospital, Athens, Greece

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Anna Angelousi First Department of Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece

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Georgios-Marios Makris Department of Gynecology, Euroclinic Hospital, Athens, Greece

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Eva Kassi First Department of Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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gastrointestinal tract; however, other organs may also be affected. A prerequisite for the occurrence of MALT lymphoma is abundance of lymphoid tissue in the affected organ; therefore, it is usually seen in the salivary gland, the thyroid, the eye, the skin, and

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000502204
Volume/Issue:
Volume 9: Issue 1
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Till Ittermann Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Adrian Richter Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
German Rheumatism Research Center, Berlin, Germany

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Martin Junge Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Matthias Nauck Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

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Astrid Petersmann Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
Institute for Clinical Chemistry, Interdisciplinary University Laboratory, University Medicine Göttingen, Göttingen, Germany

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Clemens Jürgens Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Harald Below Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany

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Carsten Oliver Schmidt Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Henry Völzke Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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variations. For example, individual urinary iodine excretion levels vary strongly from day to day and during the day because they mainly depend on previous food intake [ 2 ]. Diurnal and seasonal variations have also been reported for thyroid hormone levels

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000507018
Volume/Issue:
Volume 10: Issue 2
Open access
Robert Opitz Institute of Interdisciplinary Research in Molecular Human Biology, Université Libre de Bruxelles, Brussels, Belgium

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Francesco Antonica Institute of Interdisciplinary Research in Molecular Human Biology, Université Libre de Bruxelles, Brussels, Belgium

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Sabine Costagliola Institute of Interdisciplinary Research in Molecular Human Biology, Université Libre de Bruxelles, Brussels, Belgium

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Introduction Congenital hypothyroidism (CH) represents the most common congenital endocrine disorder in humans affecting approximately 1 of 2,000-4,000 live births [ 1 , 2 ]. The majority of CH cases are due to thyroid dysgenesis (TD), which

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000357079
Volume/Issue:
Volume 2: Issue 4
Free access