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Regional Center for Newborn Screening, Diagnosis and Treatment of Congenital Metabolic and Endocrinological Diseases, Verona, Italy
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Pediatric Section, Department Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
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Regional Center for Newborn Screening, Diagnosis and Treatment of Congenital Metabolic and Endocrinological Diseases, Verona, Italy
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Pediatric Section, Department Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
Regional Center for the Diagnosis and Treatment of Children and Adolescents Rare Skeletal Disorders, Pediatric Clinic, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
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pregnancy. The median values are represented as a horizontal line. The edges represent respectively the 25th and the 75th centile of the cohort. Vertical lines represent the range. FT4, free thyroxine; LT4, levothyroxine; DBS, dried blood spot; TSH, thyroid
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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-Ab, anti-thyroid peroxidase antibodies. TSH and free thyroxine (fT4) have a complex, nonlinear relationship, and small variations in fT4 circulating levels result in substantial changes in serum TSH ( 5 ). For this reason, the TSH is the most
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between the pregnancy and non-pregnancy groups. Assay Serum free thyroxine (FT4), free triiodothyronine (FT3), and thyrotropin or thyroid stimulating hormone (TSH) levels were measured using electrochemiluminescence immunoassay kits (ECLusys FT4
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Committee on Molecular Metabolism and Nutrition, University of Chicago, Chicago, Illinois, USA
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Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
Committee on Genetics, University of Chicago, Chicago, Illinois, USA
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free thyroxine (FT4) and TSH levels and presented a mix of hypothyroid and hyperthyroid symptoms. TFT results while she was taking 137 µg of LT4 daily are shown in Figure 1 . The proband had elevated serum total thyroxine (TT4), FT4 index (FT4I), total
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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demonstrated ( 4 , 5 , 6 , 7 ). RTHβ, firstly described by Refetoff in 1967 ( 8 ), is characterized by elevated circulating free thyroxine (fT4) and free tri-iodothyronine (fT3) together with an unsuppressed thyroid-stimulating hormone (TSH). RTHβ is
Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China
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Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Heping District, Shenyang, Liaoning, China
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Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China
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. TSH, TPOAb, and TgAb levels were measured via electrochemiluminescence immunoassays with a Cobas 601 analyzer (Roche Diagnostic). Free thyroxine (fT4) and free triiodothyronine (fT3) were measured when the participant’s TSH levels were outside the
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.2 (first) to 1.68 ± 1.0 (second) and 2.02 ± 1.2 mU/l (third; p < 0.001), and serum-free thyroxine (fT 4 ) decreased from 1.22 ± 0.34 (first) to 1.01 ± 0.21 (second) and 0.96 ± 0.2 ng/ml (third; p < 0.05). Serum Tg levels did not change significantly during
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women’s next follow-up visit. Plasma samples were stored at –20°C for 6.5–13 years (range) at The Institute of Cancer Research (London, UK), and transferred to the Thyroid Research Group (Cardiff, UK) for TPOAb, thyrotropin (TSH), and free-thyroxine (FT4
Azienda USL, Modena, Italy
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Center of Genomic Research, University of Modena and Reggio Emilia
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Center of Genomic Research, University of Modena and Reggio Emilia
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) and free thyroxine (fT 4 ) [ 2 ]. Many factors are involved in thyroid hormone requirement [ 3 ], such as age [ 4 ], body weight [ 5 ], residual thyroid function [ 6 ], timing of LT 4 administration [ 7 ], food and beverages [ 8 ], concomitant
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Introduction Hypothyroidism is the most common disorder of thyroid function in pregnancy [ 1 ]. Subclinical hypothyroidism (SCH) is defined as serum thyroid-stimulating hormone (TSH) >97.5% and normal free thyroxine (FT 4 ), with or without