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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
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than differentiated thyroid cancer; There are scarce data about malignant SO evolution during pregnancy. Novel Insight Pregnancy may represent a stimulus for malignant SO growth in patients with previous biochemical evidence of
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Introduction Hypothyroidism is the most common disorder of thyroid function in pregnancy [ 1 ]. Subclinical hypothyroidism (SCH) is defined as serum thyroid-stimulating hormone (TSH) >97.5% and normal free thyroxine (FT 4 ), with or without
London School of Hygiene and Tropical Medicine, London
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Introduction Hyperthyroidism in pregnancy is a serious condition, resulting in increased risk of adverse obstetric outcomes including miscarriage, stillbirth, pre-term birth and intra-uterine growth restriction [ 1 ]. Its management is complex
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The Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel
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hyperthyroidism and hypothyroidism both affect the fetal and neonatal thyroid. Hyperthyroidism is mainly caused by Graves’ disease, and hypothyroidism during pregnancy in most women is attributed to Hashimoto's thyroiditis. In Graves’ disease, fetal and newborn
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Introduction Population median urinary iodine concentration (UIC) is the recommended method to assess iodine status [ 1 ]. UIC in pregnancy is extensively studied and adequate maternal iodine intake is of major concern [ 2 , 3 , 4
Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea
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Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
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Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Seoul, Korea
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Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
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Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
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between selenium deficiency and the prevalence of hypothyroidism ( 5 , 6 ). During pregnancy, the thyroid undergoes various alterations, including enlargement of the thyroid gland and a concomitant increase of over 50% in the production of thyroid
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Objective: There are few reports of subacute thyroiditis (SAT) during pregnancy. This study aimed to clarify the clinical characteristics of SAT in pregnant patients. Methods and results: Seven patients diagnosed with SAT during pregnancy at our institution from January 2004 to December 2021 were identified, and their clinical findings were retrospectively examined. At SAT diagnosis, the median age was 34 [range 31-42] years, the median duration of pregnancy was 5 [4-24] weeks, and all patients had neck pain but no fever. On laboratory examination, median (range) free thyroxine, free triiodothyronine, and C-reactive protein levels were 2.66 (1.14-7.77) ng/dL, 7.1 (3.3-16.1) pg/mL, and 2.22 (0.42-5.79) mg/dL, respectively, and all patients had a hypoechoic lesion of the thyroid gland. Three patients (43%) were treated with steroids, and 3 patients (43%) received replacement therapy with levothyroxine for hypothyroidism following destructive thyroiditis. There were no pregnancy complications in any of the cases. These 7 patients (pregnancy group) were compared with 217 non-pregnant female patients (non-pregnancy group) aged 31 to 42 years who were diagnosed with SAT at our institution from 2016 to 2019. The frequency of body temperatures above 37°C was lower in the pregnancy group than in the non-pregnancy group (0% vs. 65%). Conclusion: Patients who develop SAT during pregnancy may have less fever than non-pregnant patients with SAT. There were no pregnancy complications in the pregnancy group in this study. This suggests that adverse pregnancy outcomes may be avoided by appropriate management of SAT, including hypothyroidism after destructive thyroiditis.
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France
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Introduction The thyroid hormone economy changes profoundly during pregnancy to accommodate maternal and fetal needs [ 1 ]. The main factors involved are the βHCG secretion by the placenta (with its stimulatory effect on maternal thyroid), the
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Dear Editor, The clinical evidence highlighting the importance of adequate maternal thyroid function during pregnancy for an optimal pregnancy outcome is rapidly accumulating. However, due to large differences across studies regarding study
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Pregnancy is a stress test for the thyroid [ 1 ]. In a pregnancy in which the thyroid gland has a normal physiological response, it maintains the euthyroid state by increasing the production of thyroxine-binding globulin, total thyroxine, and
