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Anita Boelen Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Nitash Zwaveling-Soonawala Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands

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Annemieke C Heijboer Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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A S Paul van Trotsenburg Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands

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) program in the Netherlands. CH is characterized by low blood thyroid hormone (TH) concentrations. When caused by defective thyroid gland development or TH synthesis (primary or thyroidal CH), typically an increased secretion of thyrotropin

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Tumay Ozgur Departments of Pathology, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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Hasan Gokce Departments of Pathology, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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Ihsan Ustun Endocrinology and Metabolism, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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Mehmet Yaldiz Departments of Pathology, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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Mehmet Mustafa Akin Departments of Pathology, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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Cumali Gokce Endocrinology and Metabolism, Mustafa Kemal University Medical Faculty, Hatay, Turkey

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-needle aspiration cytology), and histopathology-confirmed Riedel thyroiditis. Introduction Riedel’s thyroiditis (RT) is a rare inflammatory disease that results in fibrosis of the thyroid gland and invasion to the surrounding structures of the neck [ 1 , 2

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Tetsuya Hiraiwa Hiraiwa Thyroid Clinic, Ibaraki City
Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Naoyuki Tsujimoto Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Keiji Tanimoto Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Jungo Terasaki Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Nobuyuki Amino Kuma Hospital, Kobe, Japan

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Toshiaki Hanafusa Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Introduction In 1987, Ralls et al. [ 1 ] first used color Doppler ultrasonography (CDU) to show increased blood flow to the thyroid gland in patients with Graves' disease (GD). Since then, CDU has been used to investigate the pathogenesis of

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Laure Felix Univ. Grenoble Alpes, Department of Radiology, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France

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Peggy Jacon Univ. Grenoble Alpes, Department of Cardiology, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France

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Maxime Lugosi Univ. Grenoble Alpes, Department of Internal Medicine, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France

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Justine Cristante Univ. Grenoble Alpes, Department of Endocrinology, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France

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Julie Roux Univ. Grenoble Alpes, Department of Nuclear Medicine, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France

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Olivier Chabre Univ. Grenoble Alpes, Department of Endocrinology, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France

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occurs. In conclusion, we show that the evolution of unenhanced radiological thyroid gland density is closely related to the evolution of thyroid function throughout the whole time course of AIT. This suggests that measurement of thyroid gland

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Elli Anagnostou Departments of Endocrinology, Alexandra General Hospital, Athens, Greece

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Antonios Polymeris Departments of Endocrinology, Alexandra General Hospital, Athens, Greece

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Georgios Morphopoulos Departments of Pathology, Alexandra General Hospital, Athens, Greece

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Alexios Travlos Departments of Endocrinology, Alexandra General Hospital, Athens, Greece

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Vassiliki Sarantopoulou Departments of Endocrinology, Alexandra General Hospital, Athens, Greece

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Irini Papaspyrou Departments of Pathology, Alexandra General Hospital, Athens, Greece

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attributable to a mass effect, such as pelvic pain. In thyrotoxic patients, serum thyroid-stimulating hormone (TSH) is low and free thyroxine (fT 4 ) and/or triiodothyronine (T 3 ) are elevated along with serum thyroglobulin (TG). The thyroid gland is typically

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Saeed Sohrabpour Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

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Farrokh Heidari Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

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Ebrahim Karimi Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

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Reza Ansari Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

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Ardavan Tajdini Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

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Firouzeh Heidari Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

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anterior neck pain, data of which are presented in Table 1 . Patients’ physical examination revealed markedly painful, tender, and slightly enlarged thyroid gland. With suspicion to SAT, cervical ultrasonography was performed for each patient. The

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Sampath Satish Kumar Departments of Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Sheila Fraser Departments of Endocrine Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Andrew Scarsbrook Departments of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Ken MacLennan Leeds Institute of Molecular Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Mark Lansdown Departments of Endocrine Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Robert D. Murray Departments of Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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What Is Known about This Topic • Riedel’s thyroiditis is a rare condition of unknown aetiology, characterised by chronic inflammatory invasive fibrosclerosis of the thyroid gland and surrounding structures. Riedel’s thyroiditis is also

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Mohammad-Reza Mahmoudian-sani Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Department of Genetics and Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

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Ameneh Mehri-Ghahfarrokhi Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

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Majid Asadi-Samani Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran

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Gholam-Reza Mobini Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

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made to introduce a suitable marker that can predict the diverse nature of thyroid glands and as a diagnostic and prognostic factor alongside other pathological-clinical methods. Approaches to detect thyroid cancer glands include blood tests, imaging

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Steen J. Bonnema Departments of Endocrinology, Odense University Hospital, Odense

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Elisabeth S. Stovgaard Laboratory of Clinical Pharmacology Q7642, Rigshospitalet

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Søren Fast Departments of Endocrinology, Odense University Hospital, Odense

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Kasper Broedbaek Laboratory of Clinical Pharmacology Q7642, Rigshospitalet

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Jon T. Andersen Laboratory of Clinical Pharmacology Q7642, Rigshospitalet

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Allan Weimann Laboratory of Clinical Pharmacology Q7642, Rigshospitalet

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Peter Grupe Departments of Nuclear Medicine, Odense University Hospital, Odense

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Laszlo Hegedüs Departments of Endocrinology, Odense University Hospital, Odense

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Henrik E. Poulsen Laboratory of Clinical Pharmacology Q7642, Rigshospitalet
Department of Clinical Pharmacology, Bispebjerg Hospital
Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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to increased intracellular oxidative stress, and eventually cell death [ 2 , 3 , 4 ]. Other organs than the thyroid gland are affected by 131 I therapy. Chromosomal alterations in peripheral lymphocytes are seen after 131 I therapy, with recovery

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Renaud Ciappuccini Department of Nuclear Medicine and Thyroid Unit, François Baclesse Cancer Centre, Caen, France
INSERM 1086 ANTICIPE, Caen University, Caen, France

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Virginie Saguet-Rysanek Department of Pathology, François Baclesse Cancer Centre, Caen, France

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Marine Dorbeau Department of Pathology, François Baclesse Cancer Centre, Caen, France

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Justine Lequesne Department of Clinical Research, François Baclesse Cancer Centre, Caen, France

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Camille Linard Department of Pathology, François Baclesse Cancer Centre, Caen, France

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Sophie Lefevre-Arbogast Department of Clinical Research, François Baclesse Cancer Centre, Caen, France

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Bénédicte Clarisse Department of Clinical Research, François Baclesse Cancer Centre, Caen, France

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Stéphane Bardet Department of Nuclear Medicine and Thyroid Unit, François Baclesse Cancer Centre, Caen, France

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thyroid nodules with indeterminate cytology, enabling malignancy in 18 FCH-negative nodules to be reliably excluded ( 3 ). Some cases of increased and diffuse 18 FCH uptake in the thyroid gland have been described in the imaging workup of patients with

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