Patrick W. Owens
Patrick W. Owens
Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland
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Terri P. McVeigh
Terri P. McVeigh
Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland
Cancer Genetics Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
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Cancer Genetics Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
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Eoin J. Fahey
Eoin J. Fahey
Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland
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Marcia Bell
Marcia Bell
Department of Endocrinology, Galway University Hospital, Galway, Ireland
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Denis S. Quill
Denis S. Quill
Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland
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Michael J. Kerin
Michael J. Kerin
Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland
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Aoife J. Lowery
Aoife J. Lowery
Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland
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lobectomy alone as an option for those with tumours 1–4 cm without risk factors. Emerging evidence also advocates active surveillance for microPTC, with interval growth over 5 years observed in < 15% of patients [ 18 , 19 ]. Improved identification and
Amanda La Greca
Amanda La Greca
Endocrinology Service, Department of Medicine, New York, N.Y., USA
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Bin Xu
Bin Xu
Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill-Cornell College of Medicine, New York, N.Y., USA
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Ronald Ghossein
Ronald Ghossein
Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill-Cornell College of Medicine, New York, N.Y., USA
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R. Michael Tuttle
R. Michael Tuttle
Endocrinology Service, Department of Medicine, New York, N.Y., USA
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Mona M. Sabra
Mona M. Sabra
Endocrinology Service, Department of Medicine, New York, N.Y., USA
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metastasis on follow-up. At the discretion of the treating physician, 25 patients were initially treated with active surveillance without RAI ablation after the initial surgery. Only 3 of these patients had N1 disease, with up to 3 affected nodes measuring
Ilaria Muller
Ilaria Muller
Thyroid Research Group, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom
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Carla Moran
Carla Moran
Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Beatriz Lecumberri
Beatriz Lecumberri
Department of Endocrinology and Nutrition, La Paz University Hospital, IdiPAZ, Autonomous University of Madrid, Madrid, Spain
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Brigitte Decallonne
Brigitte Decallonne
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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Neil Robertson
Neil Robertson
Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom
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Joanne Jones
Joanne Jones
Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
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Colin M. Dayan
Colin M. Dayan
Thyroid Research Group, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom
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autoantibodies in euthyroid patients during surveillance (1,∅○○○). 8. Should Patients Be Routinely Screened with Thyroid Imaging post IRT? In the phase III clinical trials comparing alemtuzumab with interferon β-1a in highly active MS, no overall
F. Cecoli
F. Cecoli
Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa
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E.M. Ceresola
E.M. Ceresola
Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa
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V. Altrinetti
V. Altrinetti
Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa
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M. Cabria
M. Cabria
Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa
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M. Cappagli
M. Cappagli
Endocrine Unit, Sant'Andrea Hospital, La Spezia
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A. Montepagani
A. Montepagani
Endocrine Unit, Sant'Andrea Hospital, La Spezia
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C.M. Cuttica
C.M. Cuttica
Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa
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U. Filippi
U. Filippi
Evangelico Internazionale Hospital, Genoa
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D. Saverino
D. Saverino
Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa
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M. Raffa
M. Raffa
Endocrine-Metabolic Center, ASL 1, Imperia, Italy
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M. Caputo
M. Caputo
Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa
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F. Minuto
F. Minuto
Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa
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M. Giusti
M. Giusti
Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa
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M. Bagnasco
M. Bagnasco
Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa
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from observation to total thyroidectomy [ 10 ]. MPTC mortality rate is very low, ranging from 0.2 to 2.2%. The 2015 American Thyroid Association Thyroid Cancer Management Guidelines [ 11 ] state that active surveillance ‘can be considered' as an
Henry B Burch
Henry B Burch
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Endocrinology Division, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA
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Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Endocrinology Division, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA
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Petros Perros
Petros Perros
Department of Endocrinology, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
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Tomasz Bednarczuk
Tomasz Bednarczuk
Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland
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David S Cooper
David S Cooper
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
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Peter J Dolman
Peter J Dolman
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada
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Angela M Leung
Angela M Leung
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, UCLA David Geffen School of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
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Ilse Mombaerts
Ilse Mombaerts
Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium
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Mario Salvi
Mario Salvi
Department of Clinical and Community Services, Graves’ Orbitopathy Center, Endocrinology, Fondazione IRCCS Cà Granda, Milan, Italy
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Marius N Stan
Marius N Stan
Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, Minnesota, USA
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selenium selenite 100 μg twice daily for 6 months may be considered for patients with mild, active TED, particularly in regions of selenium insufficiency. Key Point 6.2.1: The clinician should regularly assess the psychosocial impact of concerns
Chantal A Lebbink
Chantal A Lebbink
Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands
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Thera P Links
Thera P Links
Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Agnieszka Czarniecka
Agnieszka Czarniecka
The Oncologic and Reconstructive Surgery Clinic, M. Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland
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Renuka P Dias
Renuka P Dias
Department of Paediatric Endocrinology and Diabetes, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, United Kingdom
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Louise Izatt
Louise Izatt
Department of Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, United Kingdom
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Heiko Krude
Heiko Krude
Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin, Berlin, Germany
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Kerstin Lorenz
Kerstin Lorenz
Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
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Markus Luster
Markus Luster
Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany
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Kate Newbold
Kate Newbold
Thyroid Therapy Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
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Arnoldo Piccardo
Arnoldo Piccardo
Department of Nuclear Medicine, EO Ospedali Galliera, Genoa, Italy
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Manuel Sobrinho-Simões
Manuel Sobrinho-Simões
University Hospital of São João, Medical Faculty and Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
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Toru Takano
Toru Takano
Thyroid Center, Rinku General Medical Center, Osaka, Japan
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A S Paul van Trotsenburg
A S Paul van Trotsenburg
Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
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Frederik A Verburg
Frederik A Verburg
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
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Hanneke M van Santen
Hanneke M van Santen
Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands
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total thyroidectomy vs active surveillance ( 91 ). Similar to the 2015 ATA Pediatric Guideline, the expert panel recommends extensive neck US in these cases to detect contralateral disease/regional lymph node spread ( 8 ). Patients with no disease in US
Eric Fliers
Eric Fliers
Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, Location AMC, Amsterdam, The Netherlands
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Barbara Demeneix
Barbara Demeneix
Evolution des Régulations Endocriniennes, Département “Adaptation du Vivant”, UMR 7221 Muséum National d’Histoire Naturelle/CNRS, Paris, France
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Ashok Bhaseen
Ashok Bhaseen
, Montreal, Québec, Canada
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Thomas H. Brix
Thomas H. Brix
Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
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(however, according to patient associations, the ANSM documents requesting the formulation change have yet to be released). In January 2018, 17,310 reports of adverse effects had been received by the national site for drug surveillance (BNPV, Base National
Matthieu Bosset
Matthieu Bosset
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Maxime Bonjour
Maxime Bonjour
Service de Biostatistique, Hospices Civils de Lyon, Lyon, France
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Solène Castellnou
Solène Castellnou
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Zakia Hafdi-Nejjari
Zakia Hafdi-Nejjari
Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Claire Bournaud-Salinas
Claire Bournaud-Salinas
Centre de Médecine Nucléaire, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Myriam Decaussin-Petrucci
Myriam Decaussin-Petrucci
Service d’Anatomie-Pathologique, Hospices Civils de Lyon, Groupement Hospitalier Lyon-Sud, Pierre Bénite, France
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Jean Christophe Lifante
Jean Christophe Lifante
Service de Chirurgie Endocrinienne, Hospices Civils de Lyon, Groupement Hospitalier Lyon-Sud, Pierre Bénite, France
Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France
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Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France
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Agnès Perrin
Agnès Perrin
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Jean-Louis Peix
Jean-Louis Peix
Service de Chirurgie Endocrinienne, Hospices Civils de Lyon, Groupement Hospitalier Lyon-Sud, Pierre Bénite, France
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Philippe Moulin
Philippe Moulin
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
CarMeN Laboratory, Université Claude-Bernard Lyon 1, Inserm U1060, INRA U1397, INSA Lyon, IMBL, Villeurbanne, France
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CarMeN Laboratory, Université Claude-Bernard Lyon 1, Inserm U1060, INRA U1397, INSA Lyon, IMBL, Villeurbanne, France
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Geneviève Sassolas
Geneviève Sassolas
Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Michel Pugeat
Michel Pugeat
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Françoise Borson-Chazot
Françoise Borson-Chazot
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France
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Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France
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benefit from active surveillance instead of surgery [ 4 , 26 , 27 ]. Their incidence is increasing as they are often found fortuitously, leading to an overdiagnosis of thyroid cancers [ 4 , 28 - 30 ]. In line with the present results, contralateral
Gilles Russ
Gilles Russ
Thyroid and Endocrine Tumors, Institute of Endocrinology, Pitié Salpêtrière Hospital, Pierre and Marie Curie University, Paris, France
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Steen J. Bonnema
Steen J. Bonnema
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Murat Faik Erdogan
Murat Faik Erdogan
Department of Endocrinology and Metabolism, University of Ankara School of Medicine, İbni Sina Hastanesi, Ankara, Turkey
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Cosimo Durante
Cosimo Durante
Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy
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Rose Ngu
Rose Ngu
Head Neck and Thyroid Imaging, Department of Radiology, Guy’s and St Thomas’ Hospitals NHS Foundation Trust, London, United Kingdom
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Laurence Leenhardt
Laurence Leenhardt
Thyroid and Endocrine Tumors, Institute of Endocrinology, Pitié Salpêtrière Hospital, Pierre and Marie Curie University, Paris, France
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cytological result, FNA should be repeated within 3 months to reduce the rate of false-negative samples. In case of subcentimeter nodules with high-risk US features, active surveillance is recommended, provided that there are no abnormal lymph nodes and the
Rui Guo
Rui Guo
Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China
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Bowen Zheng
Bowen Zheng
Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China
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Tao Wu
Tao Wu
Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China
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Yufan Lian
Yufan Lian
Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China
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Tinghui Yin
Tinghui Yin
Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China
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Yuting He
Yuting He
Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China
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Jingya Qin
Jingya Qin
Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China
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Zhicheng Yao
Zhicheng Yao
Department of General Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China
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Wen Xu
Wen Xu
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China
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Jie Ren
Jie Ren
Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China
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using the VRS01 RFA system (STARmed, Korea) and initiated internal cooling of the 18G electrodes with 10 mm or 7 mm active tips under the guidance of the same US equipment. Local anesthesia, a lateral approach, a moving-shot technique, and a
