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Maria Lopes-Pereira Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Hospital de Braga, Braga, Portugal

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Anna Quialheiro Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal

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Patrício Costa Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal

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Susana Roque Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal

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Nadine Correia Santos Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
ACMP5 – Associação Centro de Medicina P5 (P5), School of Medicine, University of Minho, Braga, Portugal

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Margarida Correia-Neves Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal

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Ana Goios Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal

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Ivone Carvalho Newborn Screening, Metabolism & Genetics Unit, National Institute of Health Dr Ricardo Jorge, Porto, Portugal

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Tim I M Korevaar Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, the Netherlands
Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands
The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands

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Laura Vilarinho Newborn Screening, Metabolism & Genetics Unit, National Institute of Health Dr Ricardo Jorge, Porto, Portugal

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Joana Almeida Palha Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Clinical Academic Center-Braga (2CA-B), Braga, Portugal

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Introduction Iodine is an essential nutrient required for the biosynthesis of thyroid hormone. Thyroid hormone regulates growth and metabolism and is essential for proper fetal brain- and nervous system development ( 1 ). During pregnancy

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Rodrigo Moreno-Reyes Department of Nuclear Medicine, Hospital Erasme, Université Libre de Bruxelles, Brussels, Belgium

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Ulla Feldt-Rasmussen Department of Endocrinology and Metabolism, University Hospital Rigshospitalet, and Faculty of Ηealth and Clinical Sciences, University of Copenhagen, Copenhagen, Denmark

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Agnieszka Piekiełko-Witkowska Centre of Postgraduate Medical Education, Centre of Translational Research, Department of Biochemistry and Molecular Biology, Warsaw, Poland: Basic Lead of the European Society of Endocrinology Focus Area on Thyroid

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Adriana Gaspar da Rocha Public Health Unit, ULS Baixo Mondego, Figueira da Foz, Portugal Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal

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Corin Badiu National Institute of Endocrinology "C. Davila" University of Medicine and Pharmacy, Bucharest, Romania

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Josef Köhrle Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Experimentelle Endokrinologie, Berlin, Germany: Co-Lead of the European Society of Endocrinology Focus Area on Environmental Endocrinology

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Leonidas Duntas Evgenideion Hospital, Unit of Endocrinology, Metabolism and Diabetes, National Kapodistrian University of Athens, Athens, Greece

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Introduction Why is European Chemicals Agency’s (ECHA) statement not considered scientifically accurate by the thyroid community? The ECHA statement made in September 2022 ( 1 ) concluding that iodine is an endocrine disruptor (ED) and the

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Joachim N Nilsson Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden

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Jonathan Siikanen Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Vincenzo Condello Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Kenbugul Jatta Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden

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Ravi Saini Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden

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Christel Hedman Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Stockholms Sjukhem Foundation's Research and Development Department, Stockholm, Sweden
Department of Clinical Sciences Lund, Lund University, Lund, Sweden

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Catharina Ihre Lundgren Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden

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adequate uptake and trapping of iodine in the target tissue, which is conceptualised as iodine avidity. For most patients with low-risk disease, post-surgical treatment includes thyroid remnant ablation – a highly iodine avid target. However, in the

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Line Tang Møllehave Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Nils Knudsen Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Denmark

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Allan Linneberg Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Inge Bülow Pedersen Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark

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Gitte Ravn-Haren Research Group for Risk Benefit, National Food Institute, Technical University of Denmark, Lyngby, Denmark

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Anja Lykke Madsen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Allan Carlé Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark

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Charlotte Cerqueira The Danish Clinical Quality Program – National Clinical Registries (RKKP), Denmark

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Anne Krejbjerg Department of Oncology, Aalborg University Hospital, Aalborg, Denmark

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Lone Banke Rasmussen Independent researcher, Klemensker, Denmark

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Lars Ovesen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Hans Perrild Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Denmark

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Lena Bjergved Sigurd Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark

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Betina Heinsbæk Thuesen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Pernille Vejbjerg Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Torben Jørgensen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Introduction: iodine fortification in Denmark The Danish investigation on iodine intake and thyroid disease (DanThyr) was the first extensive examination of the effects of an iodine fortification (IF) program ( 1 ). IF is implemented to obtain

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Ying Sun Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China

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Di Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China

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Lei Zhao Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Heping District, Shenyang, Liaoning, China

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Xiaoguang Shi Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China

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Yongze Li Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China

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Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China

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Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China

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(SCH) ( 3 ). Animal studies have shown that aging is associated with a low thyroid state and organ-specific sensitivity to thyroxine ( 4 ). Previous studies have suggested that age has an important influence on TH sensitivity ( 4 ). Iodine is the main

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Rosália P. Padovani Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil
Department of Nuclear Medicine, Irmandade Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil

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Rui M.B. Maciel Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil

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Teresa S. Kasamatsu Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil

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Beatriz C.G. Freitas Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil

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Marilia M.S. Marone Department of Nuclear Medicine, Irmandade Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil

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Cleber P. Camacho Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil

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Rosa Paula M. Biscolla Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil

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challenging factor is the iodine uptake capacity of thyroid cancer tissue, which is poorer than that of normal thyroid cells [ 4 ]. In addition, to maximize the RAI uptake by residual thyroid remnants, persistent disease, or metastases, TSH levels must be

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Marta Taida García-Ascaso Servicio de Pediatría, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain

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Susana Ares Segura Servicio de Neonatología, Hospital Universitario La Paz, Madrid, Spain

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Purificación Ros Pérez Servicio de Pediatría, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain

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Roi Piñeiro Pérez Servicio de Pediatría, Hospital General de Villalba, Madrid, Spain

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Marta Alfageme Zubillaga Servicio de Radiología, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain

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Introduction Iodine is an essential trace element required for the formation of the thyroid hormones, which are crucial for somatic and cognitive development. The recommended iodine intake is 90 µg/day from birth to 8 years of age, 120 µg

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Temesgen Muche Ewunie Department of Human Nutrition, School of Public Health, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia

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Robel Hussen Kabthymer Department of Human Nutrition, School of Public Health, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia

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Samrawit Hailu Department of Reproductive Health, School of Public Health, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia

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Moges Mareg Department of Reproductive Health, School of Public Health, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia

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Tesfa Mengie Amhara Regional Health Bureau, CDC Project Zonal Monitoring and Evaluation Officer, Dessie, Ethiopia

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Daniel Sisay Epidemiology-Biostatistics Unit, School of Public Health, College of Medicine and Health Science, Dilla University, Dilla, Ethiopia

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Getachew Arage Department of School of Public Health, College of Medicine and Health Science, Debre Tabor University, Debre Tabor, Ethiopia

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Introduction Iodine is present in the body in scarce amounts ( 1 ) and is an essential micronutrient that is required for the production of thyroid hormone which is vital for immune response, growth, and brain development of the fetus, infants

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Catarina Senra Moniz Department of Endocrinology and Nutrition, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal

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Rita Carvalho Department of Endocrinology and Nutrition, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal

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Susana Prazeres Laboratory of Endocrinology, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisboa, Portugal

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Edward Limbert Department of Endocrinology, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisboa, Portugal

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Inês Mendes Department of Endocrinology and Nutrition, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal

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Rui César Department of Endocrinology and Nutrition, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal

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Introduction Iodine is an essential micronutrient for thyroid hormone synthesis, and its deficiency during childhood has been shown to impair growth, cognition, and motor function [ 1 , 2 ]. In order to meet iodine requirements for disease

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Jean-Charles Martin Centre de recherche en CardioVasculaire et Nutrition (C2VN), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Institut National pour la Santé Et la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Marseille, France

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Thierry Pourcher Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Guillaume Phan Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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Julien Guglielmi Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Caroline Crambes Pharmacie Centrale des Armées (PCA), Direction des Approvisionnements en produits de Santé des Armées, Fleury-les-Aubrais, France

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François Caire-Maurisier Pharmacie Centrale des Armées (PCA), Direction des Approvisionnements en produits de Santé des Armées, Fleury-les-Aubrais, France

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Dalila Lebsir Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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David Cohen Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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Clément Rosique Centre de recherche en CardioVasculaire et Nutrition (C2VN), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Institut National pour la Santé Et la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Marseille, France

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Lun Jing Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Maha Hichri Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Lisa Salleron Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Jacques Darcourt Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Maamar Souidi Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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Marc Benderitter Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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years ( 1 ). It aimed to define the conditions for repetitive administration of potassium iodide (KI) in order to protect the population undergoing prolonged exposure to radioactive iodine in a nuclear or radiological accidental situation. The results

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