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Cléber P. Camacho Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Susan C. Lindsey Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Teresa S. Kasamatsu Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Alberto L. Machado Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil

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João Roberto M. Martins Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Rosa Paula M. Biscolla Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil

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Magnus R. Dias da Silva Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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José Gilberto H. Vieira Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil

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Rui M.B. Maciel Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil

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diagnosis of nodular thyroid disease (NTD) while other guidelines assume a neutral or a contrary position regarding the use of sCT for NTD due to false-positive results, cost-effectiveness, and large reference range of assays [ 2 , 3 , 4 , 5 , 6 , 7 , 8

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000363055
Volume/Issue:
Volume 3: Issue 2
Free access
Tilman Witte The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, Lebanon, N.H., USA
Institute for Community Medicine, Greifswald, Germany

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Henry Völzke Institute for Community Medicine, Greifswald, Germany

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Markus M. Lerch Departments of Medicine A, Greifswald, Germany

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Katrin Hegenscheid Departments of Diagnostic Radiology, Greifswald, Germany

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Nele Friedrich Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald School of Medicine, Greifswald, Germany

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Till Ittermann Institute for Community Medicine, Greifswald, Germany

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John A. Batsis The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, Lebanon, N.H., USA
Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, N.H., USA

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Introduction Both thyroid disease and obesity are common disorders in the general population. Several studies have found a prevalence dependent on selected reference ranges from 0.1 to 2% for hypothyroidism [elevated thyroid

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000450977
Volume/Issue:
Volume 6: Issue 1
Free access
Sze May Ng Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
Department of Paediatrics, Southport and Ormskirk NHS Trust, Ormskirk, United Kingdom

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Mark A. Turner Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

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Shivaram Avula Department of Radiology, Alder Hey Foundation Trust Hospital, Liverpool, United Kingdom

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21 Mikołajczak A, Borszewska-Kornacka MK, Bokiniec R: Sonographic reference ranges for the thyroid gland in euthyroid term newborns. Am J Perinatol 2015; 32: 1257–1262. 10.1055/s-0035-1552937 26023906 22 Mahajan SD, Aalinkeel R, Singh S

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000481857
Volume/Issue:
Volume 7: Issue 1
Free access
Françoise Brucker-Davis Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Patricia Panaïa-Ferrari Departments of Biochemistry, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Jocelyn Gal Departments of Biostatistics, CHU de Nice, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Patrick Fénichel Department of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, Université Nice-Sophia Antipolis, Nice, France

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Sylvie Hiéronimus Department of Endocrinology, Diabetology and Reproductive Medicine

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5th or 10th percentile of the reference range for FT4 associated with normal TSH [ 3 , 4 ]. There is, however, the question of threshold for normal values, linked in part to the lack of laboratory reference ranges in pregnancy. The association of

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000350882
Volume/Issue:
Volume 2: Issue 3
Free access
Yiyun Cui Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China

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Jinlong Chen Department of Cardiology, Children's Hospital of Nanjing Medical University, Nanjing, China

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Rui Guo Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China

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Ruize Yang Department of Public Health, Children's Hospital of Nanjing Medical University, Nanjing, China

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Dandan Chen Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China

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Wei Gu Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China

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Francis Manyori Bigambo School of Public Health, Nanjing Medical University, Nanjing, China

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Xu Wang Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China

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remission and relapse groups on admission. Reference ranges Remission group ( n  = 39) Relapse group ( n  = 40) P ALT (U/L) 5–40 25.00 (19.00–37.00) 28.50 (21.75–37.50) 0.50 AST (U/L) 5–40 25.00 (20

Article Type:
Research Article
Collections:
Hyperthyroidism and thyrotoxicosis
DOI:
https://doi.org/10.1530/ETJ-23-0018
Volume/Issue:
Volume 12: Issue 3
Open access
Hiroyuki Iwaki Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Kenji Ohba Medical Education Center, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Eisaku Okada Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Takeshi Murakoshi Obstetrics and Gynecology, Maternal and Perinatal Care Center, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Yumiko Kashiwabara Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Chiga Hayashi Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Akio Matsushita Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Shigekazu Sasaki Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Takafumi Suda Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Yutaka Oki Department of Metabolism and Endocrinology, Hamamatsu-Kita Hospital, Hamamatsu, Japan

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Rieko Gemma Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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dosage that ensures maternal serum free thyroxine (FT4) levels at or moderately above the upper limit of the reference range is reported to be appropriate for fetal euthyroid status [ 2 ]. This recommendation was incorporated into the 2017 American

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000509324
Volume/Issue:
Volume 10: Issue 5
Free access
Wilmar M. Wiersinga Department of Endocrinology and Metabolism

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Noortje I. Regensburg Orbital Center, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Maarten P. Mourits Orbital Center, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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certain extent also the rather wide interindividual variation observed in orbital volumes (OV range 20.7-34.5 cm 3 , FV range 9.2-25.7 cm 3 , MV range 2.47-5.42 cm 3 ). Reference values, however, had to be age specific. Reference intervals of FV/OV and MV

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000348246
Volume/Issue:
Volume 2: Issue 1
Free access
Johannes W. Dietrich Department of Endocrinology and Diabetes, Medical Hospital I, Germany

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Patrick Müller Department of Cardiology and Angiology, Medical Hospital II, Germany
Heart Center Bad Neustadt, Clinic for Interventional Electrophysiology, Bad Neustadt an der Saale, Germany

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Fabian Schiedat Department of Cardiology and Angiology, Medical Hospital II, Germany

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Markus Schlömicher Department of Cardiac Surgery, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, Germany

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Justus Strauch Department of Cardiac Surgery, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, Germany

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Apostolos Chatzitomaris Department of Endocrinology and Diabetes, Medical Hospital I, Germany

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Harald H. Klein Department of Endocrinology and Diabetes, Medical Hospital I, Germany

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Andreas Mügge Department of Cardiology and Angiology, Medical Hospital II, Germany

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Eddy Rijntjes Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Ina Lehmphul Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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FT 4 outside their respective reference ranges; (7) an insufficient amount of preoperative serum aliquots, and (8) any antiarrhythmic medication pre- or perioperatively with the exception of β-blocking agents and verapamil. All patients had received

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000381543
Volume/Issue:
Volume 4: Issue 2
Free access
Wilmar M. Wiersinga Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Leonidas Duntas Endocrine Unit, Evgenidion Hospital, University of Athens Medical School, Athens, Greece

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Valentin Fadeyev Federal Endocrinological Scientific Center, Moscow, Russia

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Birte Nygaard Department of Endocrinology, Herlev Hospital, Herlev, Denmark

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Mark P.J. Vanderpump Department of Endocrinology, Royal Free Hampstead NHS Trust, London, UK

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been on L-T4 for a minimum of 4 months and had normal serum TSH values (local reference ranges were 0.1–5.5 or 0.2–6.0 mU/l) were compared with 535 age- and sex-matched controls [ 11 ]. Two questionnaires were used: the General Health Questionnaire (GHQ

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000339444
Volume/Issue:
Volume 1: Issue 2
Free access
Tanja Diana Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Hans-Peter Holthoff AdvanceCor GmbH, Martinsried, Germany

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Julia Fassbender AdvanceCor GmbH, Martinsried, Germany

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Christian Wüster Endocrine Laboratory and Practice Prof. Wüster, Mainz, Germany

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Michael Kanitz Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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George J. Kahaly Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Martin Ungerer AdvanceCor GmbH, Martinsried, Germany

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manufacturer’s instructions. The reference ranges in humans for fT4 and TBII are 0.9–1.8 ng/mL and 0.1–40.0 IU/L, respectively, while the cut-off for the bridge binding TBII immunoassay is 0.55 IU/L. Neat serum samples (approx. 50 µL) were used to measure fT4

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000508790
Volume/Issue:
Volume 9: Issue 1_Suppl
Free access