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Division of Interventional Radiology, European Institute of Oncology, IRCCS, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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00270-016-1313-6 . 47 Wang L , Ge M , Xu D , Chen L , Qian C , Shi K , . Ultrasonography-guided percutaneous radiofrequency ablation for cervical lymph node metastasis from thyroid carcinoma . J Cancer Res Ther . 2014 Nov ; 10
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histopathological findings. All the patients presented negative anti-thyroglobulin antibody in serum, well-differentiated type of papillary thyroid carcinoma and lymph node metastasis on histopathology. Cervical lymph nodes swelling indicating metastasis were
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Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
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Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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following treatment may affect up to 30% of patients ( 3 , 4 ), with cervical lymph node metastasis (LNM) in central and lateral neck compartments being well-established sites of persistent and recurrent disease. The 2015 American Thyroid Association (ATA
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cervical lymph node metastasis . Horumon To Rinsho . 2017 Jun ; 86 ( 6 ): 845 – 51 . 10.1111/cen.13322 0045-7167 20 Sugitani I , Toda K , Yamada K , Yamamoto N , Ikenaga M , Fujimoto Y . Three distinctly different kinds of
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NOVA Medical School
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extensive metastization into cervical lymph nodes, bone, lung, and liver. Due to the advanced age of the patient, extensive metastatic disease of thyroid cancer and multiple comorbidities, a multidisciplinary team decided for palliative treatment, and
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in twice-daily fractions of 1.5 Gy for 5 days a week. Twenty-two patients received radiotherapy for primary and lymph node metastasis lesions, and 11 patients received radiotherapy for primary lesions, lymph node metastasis, and regional cervical
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Nova Medical School, Lisbon, Portugal
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, Med (Q 1 ;Q 3 ), min–máx ( n = 26) 9.5 (0; 16.8), 0–45 anti-Tg, antithyroglobulin; Bi, bilateral; Uni, unilateral. Fine-needle aspiration biopsy (FNAB) of the thyroid gland or the cervical lymph nodes was performed in all
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Endocrinology Department, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
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). Previous studies have suggested some clinical differences between prepubertal and pubertal pediatric DTC. Prepubertal patients present with a greater prevalence of lymph node ( 4 , 5 ) and lung metastasis ( 6 ) at diagnosis than pubertal patients. At the
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Radiology and Nuclear Medicine, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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(s), thyroid asymmetry, or abnormal cervical lymph node(s) [ 4 ]. The Dutch association for clinical geneticists (VKGN) proposes annual surveillance of the thyroid gland in children, by means of palpation or thyroid ultrasound. The Dutch VKGN guideline for
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more lymph node involvement, distant metastasis, and multifocal disease ( 3 ). Despite this more aggressive presentation, pediatric DTC has an excellent prognosis ( 1 , 2 ). Also, the most common genetic alterations in pediatric DTC are RET-PTC and