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Pedro Weslley Rosario Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Gabriela Franco Mourão Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Maria Regina Calsolari Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Introduction Ultrasonography (US) is a widely available, noninvasive, and sensitive technique for the detection of locoregional disease in patients operated on for papillary thyroid carcinoma (PTC). After ablation or adjuvant therapy with

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Daniela Cavaco Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal

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Ana Filipa Martins Department of Endocrinology and Diabetes, Hospital da Luz, Lisbon, Portugal

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Rafael Cabrera Department of Patology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal

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Helena Vilar Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal

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Valeriano Leite Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
Nova Medical School, Lisbon, Portugal

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Introduction Papillary thyroid carcinoma (PTC) is the most common thyroid cancer, accounting for more than 85% of the thyroid malignant lesions ( 1 ). An increase of its prevalence is recognized worldwide, mainly due to overdiagnosis of

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Marco Capezzone Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Noemi Fralassi Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Chiara Secchi Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Silvia Cantara Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Lucia Brilli Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Tania Pilli Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Fabio Maino Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Raffaella Forleo Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Furio Pacini Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Gabriele Cevenini Department of Medical Biotechnologies, University of Siena, Siena, Italy

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Alessandra Cartocci Department of Medical Biotechnologies, University of Siena, Siena, Italy

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Maria Grazia Castagna Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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. 10.1530/ERC-16-0067 27807061 1351-0088 7 Pinto AE , Silva GL , Henrique R , Menezes FD , Teixeira MR , Leite V , et al. Familial vs sporadic papillary thyroid carcinoma: a matched-case comparative study showing similar

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Elen Dias Accordi Group for Advanced Molecular Investigation (NIMA), Graduate Program in Health Sciences (PPGCS), School of Medicine (EM), Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba

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Paraskevi Xekouki Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics (PDEGEN) and Pediatric Endocrinology Inter-Institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)

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Bruna Azevedo Group for Advanced Molecular Investigation (NIMA), Graduate Program in Health Sciences (PPGCS), School of Medicine (EM), Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba

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Rodrigo Bertollo de Alexandre Group for Advanced Molecular Investigation (NIMA), Graduate Program in Health Sciences (PPGCS), School of Medicine (EM), Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba

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Carla Frasson Group for Advanced Molecular Investigation (NIMA), Graduate Program in Health Sciences (PPGCS), School of Medicine (EM), Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba
Álvaro Center for Analysis and Clinical Research - Diagnósticos da América (DASA), Cascavel, Brazil

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Siliane Marie Gantzel Group for Advanced Molecular Investigation (NIMA), Graduate Program in Health Sciences (PPGCS), School of Medicine (EM), Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba

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Georgios Z. Papadakis Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health (NIH), Bethesda, Md., USA

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Anna Angelousi Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics (PDEGEN) and Pediatric Endocrinology Inter-Institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)

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Constantine A. Stratakis Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics (PDEGEN) and Pediatric Endocrinology Inter-Institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)

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Vanessa Santos Sotomaior Group for Advanced Molecular Investigation (NIMA), Graduate Program in Health Sciences (PPGCS), School of Medicine (EM), Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba

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Fabio R. Faucz Group for Advanced Molecular Investigation (NIMA), Graduate Program in Health Sciences (PPGCS), School of Medicine (EM), Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba
Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics (PDEGEN) and Pediatric Endocrinology Inter-Institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)

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collectively classified as well-differentiated thyroid cancers and account for around 95% of thyroid malignancies. Although the majority of papillary and follicular thyroid carcinomas are sporadic, familial tumors may account for 5-10% of thyroid carcinoma

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Dillwyn Williams Department of Public Health, University of Cambridge, Cambridge, UK

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incidence at age 30-39 is about the same as the incidence in those over 80. The great majority of thyroid carcinomas are papillary in type. This analysis is primarily concerned with papillary carcinoma, although the main conclusions on age of origin will

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Francesca Carlomagno Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Università degli Studi di Napoli Federico II, Napoli, Italia

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of the RET gene have been identified in two different types of thyroid neoplasia: medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma. RET Mutations in MTC: A New Target for Cancer Treatment MTC arises from neural crest

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Nooshin Zargari Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran

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Maral Mokhtari Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran

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carcinoma (FC), and follicular variant of papillary thyroid carcinoma (FVPTC). The standard diagnosis of thyroid tumors is based on hematoxylin-eosin (HE)-stained slides, but sometimes the diagnosis of thyroid lesions, especially follicular patterned thyroid

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Anne-Sophie Bertrand Department of Interventional Radiology Imaging, Antoine Lacassagne Cancer Research Center, Nice, France

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Antoine Iannessi Department of Interventional Radiology Imaging, Antoine Lacassagne Cancer Research Center, Nice, France

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Isabelle Peyrottes Department of Anatomopathology, Antoine Lacassagne Cancer Research Center, Nice, France

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Alexis Lacout Department of Radiology, Centre médico-chirurgical ELSAN, Aurillac, France

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Antoine Thyss Department of Oncology, Antoine Lacassagne Cancer Research Center, Nice, France

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Pierre-Yves Marcy Department of Interventional Radiology and Diagnostic Imaging, Polyclinique Les Fleurs Groupe ELSAN, Ollioules, France

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case of tumor-to-tumor metastasis from a well-differentiated papillary thyroid carcinoma (PTC) into a benign uterine leiomyoma. Case Presentation We present the case of a 53-year-old female patient with a slow-growing latero-uterine mass on

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Andrea Palermo Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

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Andrea Napolitano Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy

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Daria Maggi Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

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Anda Mihaela Naciu Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

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Gaia Tabacco Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

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Silvia Manfrini Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

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Anna Crescenzi Department of Anatomic Pathology, Campus Bio-Medico University, Rome, Italy

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Chiara Taffon Department of Anatomic Pathology, Campus Bio-Medico University, Rome, Italy

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Francesco Pantano Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy

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Bruno Vincenzi Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy

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Guiseppe Tonini Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy

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Daniele Santini Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy

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papillary thyroid carcinoma. The presence of histiocyte aggregates on the site where the prior nodule had been observed supports the hypothesis of an immune-mediated tumor regression. Introduction Immune checkpoint inhibitors have been

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Daniela Dias Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Inês Damásio Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Pedro Marques Endocrinology Department, Hospital de Santa Maria, Centro Hospitalar Universitário de Lisboa Norte (CHULN), Lisbon, Portugal

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Helder Simões Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Ricardo Rodrigues Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Branca Maria Cavaco Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Nova Medical School: Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon, Portugal

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response. Discussion Follicular thyroid carcinoma (FTC) is a rare cancer, corresponding to less than 10% of all differentiated thyroid cancer (DTC). Compared to classic papillary thyroid carcinoma (PTC), FTC displays a different clinical behavior

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