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P. Beck-Peccoz Department of Clinical Sciences and Community Health, University of Milan, Endocinology and Diabetology Unit, Fondazione IRCCS Cà Granda Policlinico

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A. Lania Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, University of Milan, Endocrine Unit, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy

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A. Beckers Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Université de Liège, Liège, Belgium

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K. Chatterjee Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK

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J.-L. Wemeau CHRU, Hôpital Claude-Huriez, Clinique Endocrinologique Marc-Linquette, Lille, France

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.328.7454.1490 15205295 8 Guyatt GH, Cook DJ, Jaeschke R, Pauker SG, Schunemann HJ: Grades of recommendation for antithrombotic agents: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, ed 8. Chest 2008

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Richard T. Kloos Divisions of Endocrinology, Diabetes and Metabolism, and Nuclear Medicine, Departments of Internal Medicine and Radiology, The Ohio State University, Columbus, Ohio, USA

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Introduction The European Thyroid Association (ETA) launched a taskforce, chaired by Martin Schlumberger, to create guidelines on the treatment of metastatic medullary thyroid cancer (MTC) [ 1 ]. The decision to create a focused guideline

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Laura Fugazzola Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Rossella Elisei Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Dagmar Fuhrer Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany

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Barbara Jarzab Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Institute, Oncology Center, Gliwice Branch, Gliwice, Poland

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Université Paris Saclay, Villejuif, France

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Kate Newbold Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom

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Jan Smit Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Premise Few prospective studies are available on the management of patients with advanced thyroid cancer (TC), and the decision making is mostly based on the personal experience of physicians. The present guidelines are mainly based on the

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Leonidas H. Duntas Endocrine Unit, Evgenidion Hospital, University of Athens, Athens, Greece

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Georg Brabant Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

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Fabio Monzani Department of Clinical and Experimental Medicine, Università di Pisa, Pisa, Italy

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Simon H.S. Pearce Institute of Genetic Medicine, Newcastle University, UK
Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Robin Patrick Peeters Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Salman Razvi Institute of Genetic Medicine, Newcastle University, UK
Queen Elizabeth Hospital, Gateshead, UK

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Jean-Louis Wemeau Clinique Endocrinologique Marc-Linquette, CHU, Lille, France

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We appreciate the interest of Stott et al. [ 1 ] in the Management of Subclinical Hypothyroidism ETA Guidelines 2013 [ 2 ]. We are, however, somewhat puzzled by the authors' statement that the guidelines ‘risk doing more harm than good

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Luigi Bartalena Department of Clinical and Experimental Medicine, University of Insubria, Endocrine Unit, Ospedale di Circolo, Varese, Italy

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Lelio Baldeschi Department of Ophthalmology, Hospital Saint Luc, Catholic University of Louvain, Brussels, Belgium

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Kostas Boboridis Ophthalmology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Anja Eckstein Zentrum für Augenheilkunde, Universitätsklinikum Essen, Essen

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George J. Kahaly Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Claudio Marcocci Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Petros Perros Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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Mario Salvi Graves' Orbitopathy Center, Endocrinology, Fondazione Ca' Granda IRCCS, University of Milan, Milan, Italy

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Wilmar M. Wiersinga Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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been in widespread use ever since. Guidelines for the management of hyperthyroidism by the American Thyroid Association and American Association of Clinical Endocrinologists were published in 2011; recommendations were made on how hyperthyroidism should

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Petros Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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References 1 Wiersinga WM, Duntas L, Fadeyev V, Nygaard B, Vanderpump MPJ: 2012 ETA Guidelines: the use of L-T4 + L-T3 in the treatment of hypothyroidism. Eur Thyroid J 2012;1:55–71. 2 Bunevicius R, Kazanavicius G, Zalinkevicius R

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Salman Razvi Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Bronia Arnott Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Dawn Teare Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Shaun Hiu Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Nicki O’Brien Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom

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Simon H. Pearce Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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not specifically highlight that age should be a criterion when considering treatment in patients with mild SCH, although it does state that normal serum TSH reference range changes with age [ 20 ]. It is unclear whether guidelines formulated by these

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X Y Hu Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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J Wu Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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P Seal EFW Radiology, Calgary, Alberta, Canada

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S A Ghaznavi Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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C Symonds Department of Medicine, Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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S Kinnear Department of Medicine, Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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R Paschke Department of Medicine, Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Introduction Thyroid ultrasound (TUS) is the most sensitive and cost-effective modality for the evaluation of thyroid nodules ( 1 ). When thyroid nodules are incidentally discovered on other imaging modalities, current guidelines suggest that

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Kris Poppe Endocrine Unit, Department of Internal Medicine, University Hospital UZ Brussel (VUB), Brussels, Belgium

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Alicja Hubalewska-Dydejczyk Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland

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Peter Laurberg Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce

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Francesco Vermiglio Cattedra di Endocrinologia, Policlinico Universitario, Messina, Italy

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Bijay Vaidya Department of Endocrinology, Royal Devon & Exeter Hospital, Exeter, UK

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(PTU) is associated with rare but severe liver failure [ 7 , 8 ]. The Endocrine Society guidelines on the management of thyroid disorders, including hyperthyroidism, during pregnancy were published in 2007 [ 9 ]. The aim of this questionnaire survey was

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Luigino Dal Maso Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Daniela Pierannunzio National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy

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Silvia Francisci National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy

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Angela De Paoli Epidemiological Department, Azienda Zero, Padova, Italy

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Federica Toffolutti Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Salvatore Vaccarella Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France

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Silvia Franceschi Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Ugo Fedeli Epidemiological Department, Azienda Zero, Padova, Italy

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of the DEPTH Working Group
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of the DEPTH Working Group

Nuclear Medicine Department to perform this treatment. Beginning with the 2006 American Thyroid Association (ATA) guidelines, which were updated in 2009 and 2015, more selective use of RAI has been recommended ( 5 , 6 , 7 ). In 2009, RAI ablation was

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