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Nooshin Zargari Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran

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Maral Mokhtari Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran

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Introduction Thyroid lesions with a follicular pattern, which is defined as the cells arranged around a central lumen containing colloid material, consist of a large group of thyroid neoplasms, including follicular adenoma (FA), follicular

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000494430
Volume/Issue:
Volume 8: Issue 1
Free access
Massimiliano Andrioli Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano

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Chiara Carzaniga Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano

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Luca Persani Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano
Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy

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Introduction Nodular thyroid disease is a common finding, especially in females and in the elderly population. Thyroid nodules are found in 5% of the general population with the use of palpation [ 1 ], but high-resolution ultrasonography (US

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000347144
Volume/Issue:
Volume 2: Issue 1
Free access
Marco Marino Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Center for Genomic Research, Italy

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Maria Laura Monzani Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Giulia Brigante Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Katia Cioni Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Bruno Madeo Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Daniele Santi Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Antonino Maiorana Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Italy

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Stefania Bettelli Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Italy

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Valeria Moriondo Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Center for Genomic Research, Italy

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Elisa Pignatti Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Center for Genomic Research, Italy

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Lara Bonacini Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Cesare Carani Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy

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Vincenzo Rochira Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Azienda USL of Modena, Modena, Italy

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Manuela Simoni Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Italy
Center for Genomic Research, Italy
Azienda USL of Modena, Modena, Italy

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Introduction BRAF point mutations are common in papillary thyroid cancer (PTC) [ 1 ]. The most frequent missense mutation BRAF V600E is due to the replacement of valine by glutamic acid (NM_004333.4), resulting in a constitutive MEK

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000430092
Volume/Issue:
Volume 4: Issue 2
Free access
Kris Poppe Endocrine Unit, Department of Internal Medicine, University Hospital UZ Brussel (VUB), Brussels, Belgium

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Alicja Hubalewska-Dydejczyk Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland

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Peter Laurberg Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce

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Francesco Vermiglio Cattedra di Endocrinologia, Policlinico Universitario, Messina, Italy

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Bijay Vaidya Department of Endocrinology, Royal Devon & Exeter Hospital, Exeter, UK

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(GTT), which results from the direct stimulatory effect of human chorionic gonadotrophin on the thyroid gland, is also fairly common and accounts for ∼10% of cases. It most often presents as a subclinical hyperthyroidism in the first half of gestation

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000336101
Volume/Issue:
Volume 1: Issue 1
Free access
Catherine Brophy Departments of Otolaryngology - Head and Neck Surgery, Cork, Ireland

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Rania Mehanna Departments of Otolaryngology - Head and Neck Surgery, Cork, Ireland

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Julie McCarthy Departments of Cytopathology, Cork University Hospital, Cork, Ireland

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Antoinette Tuthill Departments of Endocrinology, Cork University Hospital, Cork, Ireland

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Matthew S. Murphy Departments of Endocrinology, South Infirmary Victoria University Hospital, Cork, Ireland

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Patrick Sheahan Departments of Otolaryngology - Head and Neck Surgery, Cork, Ireland

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Introduction Thyroid nodules are common, being present by palpation in up to 5% of individuals and by ultrasonography (US) in up to 50% [ 1 ]. While the overwhelming majority are benign, it is estimated that the incidence of cancer in

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000441221
Volume/Issue:
Volume 4: Issue 4
Free access
Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Matteo Rucco United Technology Research Center, Trento, Italy

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Annalisa Creanza Division of Endocrinology and Metabolism, Mauriziano Hospital Umberto I, Turin, Italy

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Alberto Mormile Division of Endocrinology and Metabolism, Mauriziano Hospital Umberto I, Turin, Italy

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Paolo Piero Limone Division of Endocrinology and Metabolism, Mauriziano Hospital Umberto I, Turin, Italy

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Roberto Garberoglio Division of Endocrinology and Metabolism, Molinette Hospital, Turin, Italy

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Stefano Spiezia Endocrine Surgery, Ospedale del Mare, ASL NA1 Centro, Naples, Italy

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Salvatore Monti Endocrinology Unit, Azienda Ospedaliera Universitaria Sant’Andrea, Rome, Italy

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Christian Cugini Radiology Department, Villa Salus Hospital, Venice, Italy

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Ghassan El Dalati Radiology Department, Policlinico G.B. Rossi, Verona, Italy

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Maurilio Deandrea Division of Endocrinology and Metabolism, Mauriziano Hospital Umberto I, Turin, Italy

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Introduction Thyroid nodules are a common finding in endocrine clinical practice. Their prevalence is approximately 5% when detected by palpation but may occur at 70% frequency when the thyroid is examined by ultrasound [ 1 - 3 ]. Most nodules

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000504882
Volume/Issue:
Volume 9: Issue 4
Free access
Taha Yusuf Kuzan Department of Radiology, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkey

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Ceren Canbey Goret Department of Surgical Pathology, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkey

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Introduction Nodule development is a commonly seen entity in the thyroid gland, and 4–7% of the adult population has a palpable thyroid nodule [ 1 ]. With imaging modalities, especially the widespread use of ultrasound

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000504094
Volume/Issue:
Volume 9: Issue 1
Free access
Caroline M J van Kinschot Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands
Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Ivona Lončar Academic Center for Thyroid Diseases, Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Tessa M van Ginhoven Academic Center for Thyroid Diseases, Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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W Edward Visser Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Robin P Peeters Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Charlotte van Noord Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands

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the Thyroid Network Study Group †
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the Thyroid Network Study Group

observations is needed in hospitals with varying numbers of thyroid surgeries and experience. Therefore, we developed a symptom-based treatment algorithm for our multicenter thyroid network. A protocolized schedule to phase out supplementation was included

Article Type:
Research Article
Collections:
Goiter and thyroid nodules
DOI:
https://doi.org/10.1530/ETJ-23-0044
Volume/Issue:
Volume 12: Issue 6
Open access
Roberto Negro Division of Endocrinology, ‘V. Fazzi' Hospital, Lecce

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Roberto Attanasio Endocrinology Service, Galeazzi Institute IRCCS, Milan

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Franco Grimaldi Endocrinology and Metabolic Disease Unit, Azienda Ospedaliero-Universitaria ‘S. Maria della Misericordia', Udine

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Claudio Marcocci Department of Clinical and Experimental Medicine, University of Pisa, Pisa

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Rinaldo Guglielmi Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Enrico Papini Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Introduction An essential trace element, selenium (Se) is required for correct immune system function and plays a key role in thyroid physiology [ 1 ]. Se is incorporated into the molecular structures of some proteins. These so

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000447667
Volume/Issue:
Volume 5: Issue 3
Free access
Sule Canberk Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal

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Joana C. Ferreira Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal

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Luísa Pereira Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal

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Rui Batısta Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal

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Andre F. Vieira Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal

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Paula Soares Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal

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Manuel Sobrinho Simões Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal
Department of Pathology and Oncology, Centro Hospitalar São João, Porto, Portugal

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Valdemar Máximo Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal

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Introduction Thyroid cancer is the most common of all endocrine malignancies. Despite the advances in its genetic characterization, many authors now accept that about 30% of thyroid cancer cases are in a genetic “dark zone” due to the lack of

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000509183
Volume/Issue:
Volume 9: Issue 6
Free access