Search for other papers by Amanda La Greca in
Google Scholar
PubMed
Search for other papers by Bin Xu in
Google Scholar
PubMed
Search for other papers by Ronald Ghossein in
Google Scholar
PubMed
Search for other papers by R. Michael Tuttle in
Google Scholar
PubMed
Search for other papers by Mona M. Sabra in
Google Scholar
PubMed
(includes more than 1 tumor focus sized ≥1 cm). Several studies have confirmed the risk of structural disease recurrence in multifocal papillary microcarcinoma treated with total thyroidectomy to be low, varying from 4 to 6% [ 4 , 5 , 6 ]. In similar
Search for other papers by Tina Toft Kristensen in
Google Scholar
PubMed
Search for other papers by Jacob Larsen in
Google Scholar
PubMed
Search for other papers by Palle Lyngsie Pedersen in
Google Scholar
PubMed
Search for other papers by Anne-Dorthe Feldthusen in
Google Scholar
PubMed
Search for other papers by Christina Ellervik in
Google Scholar
PubMed
Search for other papers by Søren Jelstrup in
Google Scholar
PubMed
Search for other papers by Jan Kvetny in
Google Scholar
PubMed
Background: The significance of perturbations of thyroid-stimulating hormone (TSH) and thyroid hormones within the laboratory reference ranges after hemithyroidectomy is unknown. Our aim was to examine changes in TSH and thyroid hormones after hemithyroidectomy for benign euthyroid goiter, focusing on tissue response by examining the mitochondrial membrane potential (MMP) of peripheral blood mononuclear cells (PBMCs) and basal oxygen consumption (V˙<smlcap>O</smlcap><sub>2</sub>). Materials and Methods: In a prospective study on 28 patients and controls, we examined serum TSH and thyroid hormones before hemithyroidectomy and 1, 3, 6 and 12 months after hemithyroidectomy for benign euthyroid goiter. In the hemithyroidectomy group, flow cytometry was used to measure the MMP of tetramethylrhodamine methyl ester (TMRM)- and MitoTracker Green (MTG)-stained PBMCs, and V˙<smlcap>O</smlcap><sub>2</sub> was measured by an Oxycon Pro apparatus. Results: One year after hemithyroidectomy, TSH had increased from a median of 0.97 mIU/l (interquartile range, IQR: 0.69-1.50 mIU/l) to 2.10 mIU/l (IQR: 1.90-3.00 mIU/l; p < 0.001); free thyroxine (fT<sub>4</sub>) had decreased from a median of 16.0 pmol/l (IQR: 14.9-17.0 pmol/l) to 14.8 pmol/l (IQR: 14.1-16.4 pmol/l; p = 0.009), whereas total triiodothyronine variations did not differ from those in controls. Concomitantly, the MMP of TMRM- and MTG-stained PBMCs was increased by 58% (p < 0.001) and 22% (p = 0.008), respectively. V˙<smlcap>O</smlcap><sub>2</sub> was increased by 14% (p = 0.01). Conclusion: Hemithyroidectomy for benign euthyroid goiter induced persistently increased TSH and decreased fT<sub>4</sub>, sustained mitochondrial hyperpolarization and increased V˙<smlcap>O</smlcap><sub>2</sub>. Our results demonstrate a decrease after hemithyroidectomy of the metabolic state to which the individual is adapted, with persistent cellular metabolic changes in a hemithyroidectomized patient group which is normally considered clinically and biochemically euthyroid.
Search for other papers by Bruno Bouça in
Google Scholar
PubMed
Search for other papers by Ana Cláudia Martins in
Google Scholar
PubMed
Search for other papers by Paula Bogalho in
Google Scholar
PubMed
Search for other papers by Lídia Sousa in
Google Scholar
PubMed
Search for other papers by Tiago Bilhim in
Google Scholar
PubMed
Search for other papers by Filipe Veloso Gomes in
Google Scholar
PubMed
Search for other papers by Élia Coimbra in
Google Scholar
PubMed
Search for other papers by Ana Agapito in
Google Scholar
PubMed
Search for other papers by José Silva-Nunes in
Google Scholar
PubMed
challenging scenario ( 2 ). The European Thyroid Association recommends emergency thyroidectomy for AIT unresponsive to medical therapy in patients with severe underlying cardiac disease or deteriorating cardiac function ( 6 ). Nevertheless, this decision
Search for other papers by Patrick Aidan in
Google Scholar
PubMed
Search for other papers by Helen Pickburn in
Google Scholar
PubMed
Search for other papers by Hervé Monpeyssen in
Google Scholar
PubMed
Search for other papers by Gilles Boccara in
Google Scholar
PubMed
is superior to endoscopic techniques in terms of completeness of resection [ 2 ], and complications after robotic thyroidectomy are no higher than experienced after open [ 10 ] or endoscopic techniques [ 15 ]; this is attributed mainly to the
University of Sheffield, Sheffield, UK
Search for other papers by Muhammad Fahad Arshad in
Google Scholar
PubMed
Search for other papers by Amardass Dhami in
Google Scholar
PubMed
Search for other papers by Gillian Quarrell in
Google Scholar
PubMed
University of Sheffield, Sheffield, UK
Search for other papers by Saba Prakash Balasubramanian in
Google Scholar
PubMed
-term complication after thyroidectomy. Hypocalcaemia appearing within first 24 h after surgery, reflecting parathyroid insufficiency, can occur in up to 30–60% of patients undergoing total thyroidectomy ( 1 ). In the majority of these patients (up to 90%), this is
Search for other papers by Lucie Allard in
Google Scholar
PubMed
Search for other papers by Jérôme Alexandre Denis in
Google Scholar
PubMed
Search for other papers by Gaëlle Godiris Petit in
Google Scholar
PubMed
Search for other papers by Gabrielle Deniziaut in
Google Scholar
PubMed
Search for other papers by Cécile Ghander in
Google Scholar
PubMed
Search for other papers by Elise Mathy in
Google Scholar
PubMed
Search for other papers by Erell Guillerm in
Google Scholar
PubMed
Search for other papers by Charlotte Lussey-Lepoutre in
Google Scholar
PubMed
Search for other papers by Laurence Leenhardt in
Google Scholar
PubMed
Search for other papers by Camille Buffet in
Google Scholar
PubMed
successfully, total thyroidectomy and central and right lymph node dissection were performed. During surgery, the subhyoid muscles and right internal jugular vein had to be excised due to cancer invasion, but the tumor was easily removed from the pharyngeal
Search for other papers by Eun Kyung Jang in
Google Scholar
PubMed
Search for other papers by Dong Eun Song in
Google Scholar
PubMed
Search for other papers by Gyungyub Gong in
Google Scholar
PubMed
Search for other papers by Jung Hwan Baek in
Google Scholar
PubMed
Search for other papers by Yun Mi Choi in
Google Scholar
PubMed
Search for other papers by Min Ji Jeon in
Google Scholar
PubMed
Search for other papers by Ji Min Han in
Google Scholar
PubMed
Search for other papers by Won Gu Kim in
Google Scholar
PubMed
Search for other papers by Tae Yong Kim in
Google Scholar
PubMed
Search for other papers by Young Kee Shong in
Google Scholar
PubMed
Search for other papers by Won Bae Kim in
Google Scholar
PubMed
histological examination of surgically removed thyroids. Subjects Patients who underwent FNA and thyroidectomy in Asan Medical Center from 2004 to 2012 were retrospectively reviewed. First, patients with FNAC findings of PTC prior to surgery were
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan
Search for other papers by Takaaki Konishi in
Google Scholar
PubMed
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for other papers by Michimasa Fujiogi in
Google Scholar
PubMed
Search for other papers by Nobuaki Michihata in
Google Scholar
PubMed
Search for other papers by Takayoshi Niwa in
Google Scholar
PubMed
Department of Health Services, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
Search for other papers by Kojiro Morita in
Google Scholar
PubMed
Search for other papers by Hiroki Matsui in
Google Scholar
PubMed
Search for other papers by Kiyohide Fushimi in
Google Scholar
PubMed
Search for other papers by Masahiko Tanabe in
Google Scholar
PubMed
Search for other papers by Yasuyuki Seto in
Google Scholar
PubMed
Search for other papers by Hideo Yasunaga in
Google Scholar
PubMed
Introduction Thyroidectomy is the only radical treatment for thyroid cancer. Several complications may occur following thyroidectomy: for example, post-operative bleeding, recurrent laryngeal nerve (RLN) paralysis, post-operative hypocalcaemia
Search for other papers by Pedro Weslley Rosario in
Google Scholar
PubMed
Search for other papers by Gabriela Franco Mourão in
Google Scholar
PubMed
Search for other papers by Maria Regina Calsolari in
Google Scholar
PubMed
thyroidectomy. Patients and Methods Study This was a prospective study. The study was approved by the local Research Ethics Committee, and the subjects gave informed consent. Patients The patients of this study were treated at our hospital
Search for other papers by Patrick W. Owens in
Google Scholar
PubMed
Cancer Genetics Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
Search for other papers by Terri P. McVeigh in
Google Scholar
PubMed
Search for other papers by Eoin J. Fahey in
Google Scholar
PubMed
Search for other papers by Marcia Bell in
Google Scholar
PubMed
Search for other papers by Denis S. Quill in
Google Scholar
PubMed
Search for other papers by Michael J. Kerin in
Google Scholar
PubMed
Search for other papers by Aoife J. Lowery in
Google Scholar
PubMed
thyroid cancer include diagnostic lobectomy for those with Thy3 or Thy4 fine-needle aspiration cytology (FNAC). Total thyroidectomy (TT) is advised for patients with Thy5 FNAC or with confirmed DTC following diagnostic lobectomy where tumour size exceeds 4
