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Else Marie Opsahl Section of Breast- and Endocrine Surgery, Department of Oncology, Oslo University Hospital, Oslo, Norway
Institute of Clinical Medicine, University of Oslo, Oslo, Norway

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Lars Andreas Akslen Section for Pathology, Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Pathology, Haukeland University Hospital Bergen, Bergen, Norway

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Ellen Schlichting Section of Breast- and Endocrine Surgery, Department of Oncology, Oslo University Hospital, Oslo, Norway

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Turid Aas Department of Breast- and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway

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Katrin Brauckhoff Department of Breast- and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway

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Anne Irene Hagen Department of Breast- and Endocrine Surgery, St. Olavs University Hospital, Trondheim, Norway

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Alf Frimann Rosenlund Section of Breast- and Endocrine Surgery, Department of Surgery, University Hospital of North Norway, Tromsø, Norway

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Eva Sigstad Department of Pathology, Oslo University Hospital, Oslo, Norway

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Krystyna K. Grøholt Department of Pathology, Oslo University Hospital, Oslo, Norway

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Lars H. Jørgensen Department of Thoracic Surgery, Oslo University Hospital, Oslo, Norway

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Trine Bjøro Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway

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, Plukker JT , Wolffenbuttel BH , Wiggers T , Sluiter WJ , Links TP . Determinants of life expectancy in medullary thyroid cancer: age does not matter . Clin Endocrinol (Oxf) . 2006 Dec ; 65 ( 6 ): 729 – 36 . 10.1111/j.1365-2265.2006.02659.x 17121523

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Simona Censi Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Elisabetta Cavedon Familial Tumor Unit, Veneto Institute of Oncology, (IOV)-IRCCS, Padua, Italy

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Sara Watutantrige-Fernando Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Susi Barollo Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Loris Bertazza Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Jacopo Manso Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Maurizio Iacobone Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Padua, Italy

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Davide Nacamulli Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Francesca Galuppini Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Gianmaria Pennelli Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Caterina Mian Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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A , Dralle H . Biomarker-based risk stratification for previously untreated medullary thyroid cancer . J Clin Endocrinol Metab . 2010 Jun ; 95 ( 6 ): 2655 – 63 . 10.1210/jc.2009-2368 20339026 0021-972X 6 Gharib H , McConahey

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Laure Cazabat Endocrinology Department, Ambroise Paré University Hospital, AP-HP, Boulogne, France
Inserm U1173, Université Versailles-Saint-Quentin, Montigny-Le-Bretonneux, France

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Aglae  Terray Endocrinology Department, Ambroise Paré University Hospital, AP-HP, Boulogne, France

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Philippe de Mazancourt UMR U1179, U1173, Université Versailles-Saint-Quentin, Montigny-Le-Bretonneux, France

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Jacques  Ropers Clinical Research Unit, Ambroise Paré University Hospital, AP-HP, Boulogne, France

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Lionel Groussin Department of Endocrinology, Cochin University Hospital, AP-HP, Paris, France
UMR 8104, Institut Cochin, Paris, France

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Marie-Laure Raffin-Sanson Endocrinology Department, Ambroise Paré University Hospital, AP-HP, Boulogne, France
Inserm U1173, Université Versailles-Saint-Quentin, Montigny-Le-Bretonneux, France

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Assistance Publique Hôpitaux de Paris funding and a grant from the Direction Générale de l’Offre de Soin: PHRC AOR01093. References 1 Ngeow J, Eng C: HABP2 in familial non-medullary thyroid cancer: will the real mutation please stand up? J Natl

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Renata Alencar Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil

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Daniel Barretto Kendler Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil

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Fernanda Andrade Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil

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Carla Nava Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil

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Daniel Bulzico Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil

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Cencita Cordeiro de Noronha Pessoa Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil

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Rossana Corbo Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil

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Fernanda Vaisman Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil

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Incl Mol Pathol . 1992 ; 62 ( 2 ): 79 – 88 . 10.1007/BF02899668 1355324 0340-6075 11 Elisei R , Lorusso L , Romei C , Bottici V , Mazzeo S , Giani C , et al. Medullary thyroid cancer secreting carbohydrate antigen 19-9 (Ca 19

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Abbas Al-Kurd Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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David J. Gross Neuroendocrine Tumor Unit, Department of Endocrinology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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David Zangen Department of Pediatrics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Karine Atlan Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Haggi Mazeh Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Unit, Department of Endocrinology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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, Frank-Raue K, van Vroonhoven TJ, Roeher HD, Wahl RA, Lamesch P, Raue F, Conte-Devolx B, Dralle H; European Multiple Endocrine Neoplasia Study Group: Early malignant progression of hereditary medullary thyroid cancer. N Engl J Med 2003; 349: 1517–1525. 10

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Marco Capezzone Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Noemi Fralassi Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Chiara Secchi Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Silvia Cantara Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Lucia Brilli Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Tania Pilli Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Fabio Maino Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Raffaella Forleo Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Furio Pacini Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Gabriele Cevenini Department of Medical Biotechnologies, University of Siena, Siena, Italy

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Alessandra Cartocci Department of Medical Biotechnologies, University of Siena, Siena, Italy

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Maria Grazia Castagna Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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Introduction The incidence of non-medullary thyroid cancer, in particular papillary thyroid cancer (PTC), has increased in many countries over the past 20 years [ 1 - 3 ]. As a consequence, also the reported incidence of the familial form of

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Sravanthi Nagavalli Division of Endocrinology and Metabolism, Torrance, CA, USA

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Marelle Yehuda Division of Endocrinology and Metabolism, Torrance, CA, USA

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Laron W. McPhaul Department of Pathology and Laboratory Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA

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Andrew G. Gianoukakis Division of Endocrinology and Metabolism, Torrance, CA, USA

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. Negative staining for calcitonin, CEA, thyroglobulin, TTF1, melan-A, and HMB45 excluded melanoma, medullary thyroid cancer, and well-differentiated thyroid cancer. While on contrast-enhanced computed tomography the lesion had appeared intrinsic to the

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Furio Pacini Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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the case of medullary thyroid cancer). Other recommendations are devoted to provide indications and timing for neck US and US-FNA. In the past literature, it was advocated that follow-up of thyroid cancer patients should go on for their entire lives

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Carles Zafon Department of Endocrinology, Hospital Vall d'Hebron, and Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona

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Juan J. Díez Department of Endocrinology and Nutrition, Hospital Ramón y Cajal
Department of Medicine, University of Alcalá de Henares, Madrid

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Juan C. Galofré Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain
IdiSNA (Instituto de investigación en la salud de Navarra), Pamplona, Spain

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David S. Cooper Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

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>TGG) mutation. Endocr Relat Cancer 2008;15:1035-1041. 75 Hu MI, Ying AK, Jimenez C: Update on medullary thyroid cancer. Endocrinol Metab Clin North Am 2014;43:423-442. 76 Verbeek HH, Plukker JT, Koopmans KP, de Groot JW, Hofstra RM, Muller Kobold

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Giovanni Mauri Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
Division of Interventional Radiology, European Institute of Oncology, IRCCS, Milan, Italy

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, University of Southern Denmark, Odense, Denmark

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Steven Bandula Interventional Oncology Service, University College Hospital, London, United Kingdom

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Roberto Luigi Cazzato Department of Interventional Radiology, University Hospital of Strasbourg, Strasbourg, France

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Agnieszka Czarniecka The Oncologic and Reconstructive Surgery Clinic, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland

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Oliver Dudeck Center for Microtherapy, Klinik Hirslanden, Zurich, Switzerland

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Laura Fugazzola Department of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Romana Netea-Maier Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Gilles Russ Thyroid and Endocrine Tumors Unit, La Pitie-Salpetriere Hospital, Sorbonne University, Paris, France

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Göran Wallin Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

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Enrico Papini Department of Endocrinology & Metabolism, Ospedale Regina Apostolorum, Albano, Italy

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). The efficacy decreased significantly according to the degree of tracheal abutment of the tumors [ 35 ]. Both LA and RFA may be used for the management of medullary thyroid cancer in patients not amenable to surgery [ 67 , 68 ]. A few case reports

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