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Hayri Bostan Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Muhammed Erkam Sencar Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Murat Calapkulu Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Sema Hepsen Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Hakan Duger Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Ilknur Ozturk Unsal Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Mustafa Ozbek Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Erman Cakal Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey

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Introduction Subacute thyroiditis (SAT) is a self-limiting, inflammatory process of the thyroid gland that often presents with painful swelling of the thyroid. SAT affects females more often than males (female to male ratio of 4:1) [ 1 - 3

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Lars Folkestad Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Frans Brandt Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark

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Thomas Brix Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Marianne Vogsen Department of Oncology, Odense University Hospital, Odense, Denmark

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Lars Bastholt Department of Oncology, Odense University Hospital, Odense, Denmark

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Peter Grupe Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark

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Jeanette  Krogh Petersen Department of Clinical Pathology, Odense University Hospital, Odense, Denmark

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark

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thyroidectomy and would be expected to occur with a much longer lag time [ 20 ]. On the other hand, the lack of histopathological signs of autoimmunity within the thyroid gland could indicate that TRAB is the result of thyroid surgery. We cannot clarify

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Wenxing Guo The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Long Tan The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Shuyao Dong The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Ya Jin The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Mei Zhu The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China

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Hongyan Wei The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China

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Yanting Chen The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Lili Fan The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Cong Du The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Wanqi Zhang The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China
The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China
Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China

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effects of variables on Tvol. Moreover, metabolic syndrome (MetS) has become a major health hazard in the modern world [ 15 ]. It was found to be related to functional/morphological abnormalities of the thyroid gland [ 16 ]. The association between MetS

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Kathrin A. Schmohl Department of Internal Medicine II, Germany

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Andrea M. Müller Department of Internal Medicine II, Germany

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Nathalie Schwenk Department of Internal Medicine II, Germany

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Kerstin Knoop Department of Internal Medicine II, Germany

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Eddy Rijntjes Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Heike Heuer Leibniz Institute for Environmental Medicine, Düsseldorf, Germany

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Peter Bartenstein Department of Nuclear Medicine, Germany

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Burkhard Göke Department of Internal Medicine II, Germany

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Peter J. Nelson Medical Policlinic IV, University Hospital of Munich, Munich, Germany

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Christine Spitzweg Department of Internal Medicine II, Germany

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published by Hamilton [ 2 ]in 1942. Since then, numerous protocols for radioiodide ablation of the mouse thyroid gland have been published with broad variation of the thyroid-lethal dose of 131 I administered to mice ranging from 28 to 1,000 µCi (1-37 MBq

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Rudolf Hoermann Department of Nuclear Medicine, Klinikum Luedenscheid, Luedenscheid, Germany

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John E.M. Midgley North Lakes Clinical, Ilkley, UK

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Rolf Larisch Department of Nuclear Medicine, Klinikum Luedenscheid, Luedenscheid, Germany

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Johannes W. Dietrich Medical Department I, Endocrinology and Diabetology, Bergmannsheil University Hospitals, Ruhr University of Bochum
Ruhr Center for Rare Diseases (CeSER), Ruhr University of Bochum and Witten/Herdecke University, Bochum, Germany

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Introduction Attainment of a physiologically adequate thyroidal state relies on the ability of the organism to (1) sufficiently raise the hormone output of the thyroid gland to a level appropriate for health and (2) supply the various tissues

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Francesco Boi Endocrinology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy

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Fabiana Pani Endocrinology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy

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Stefano Mariotti Endocrinology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy

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. Pathological series have looked at the presence of LTI in thyroid glands harboring thyroid cancer and reported a rate of associated HT, histologically defined, ranging between 5 and 48% [ 5 , 20 , 21 ]. This wide distribution may be due, at least in part, to

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Jean-Charles Martin Centre de recherche en CardioVasculaire et Nutrition (C2VN), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Institut National pour la Santé Et la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Marseille, France

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Thierry Pourcher Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Guillaume Phan Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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Julien Guglielmi Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Caroline Crambes Pharmacie Centrale des Armées (PCA), Direction des Approvisionnements en produits de Santé des Armées, Fleury-les-Aubrais, France

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François Caire-Maurisier Pharmacie Centrale des Armées (PCA), Direction des Approvisionnements en produits de Santé des Armées, Fleury-les-Aubrais, France

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Dalila Lebsir Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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David Cohen Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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Clément Rosique Centre de recherche en CardioVasculaire et Nutrition (C2VN), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Institut National pour la Santé Et la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Marseille, France

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Lun Jing Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Maha Hichri Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Lisa Salleron Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Jacques Darcourt Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Maamar Souidi Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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Marc Benderitter Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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, preclinical safety studies of repetitive ITB The ability of the thyroid gland to concentrate iodide is essential for the synthesis of thyroid hormones through a complex mechanism involving several functional proteins ( 14 , 15 ). The levels of circulating

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Tim Brandenburg Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Endocrine Tumour Center at West German Cancer Center, Member of ENDO-ERN and EURACAN, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Philipp Muchalla Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Endocrine Tumour Center at West German Cancer Center, Member of ENDO-ERN and EURACAN, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Sarah Theurer Endocrine Tumour Center at West German Cancer Center, Member of ENDO-ERN and EURACAN, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
University Duisburg-Essen, Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Kurt Werner Schmid Endocrine Tumour Center at West German Cancer Center, Member of ENDO-ERN and EURACAN, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
University Duisburg-Essen, Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Dagmar Führer Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Endocrine Tumour Center at West German Cancer Center, Member of ENDO-ERN and EURACAN, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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survival after diagnosis is comparable to anaplastic thyroid carcinoma (ATC) [ 3 , 6 , 7 ]. Before diagnosis, infiltration or metastasizing from other primary focuses of squamous cell carcinoma to the thyroid gland must be excluded [ 4 - 6 ]. Referring to

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Laura Tosatto Human Technopole, Milano, Italy

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Francesca Coscia Human Technopole, Milano, Italy

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hormone receptors (THR) ( 4 , 5 ). TH are synthesised within the thyroid gland follicles, monolayers of polarised thyrocytes enclosing a large extracellular lumen ( Fig. 1A and B ) ( 1 ). The synthesis of TH is stimulated by thyrotropin (or thyroid

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Satoshi Koyama Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan

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Naritomo Miyake Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan

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Kazunori Fujiwara Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan

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Tsuyoshi Morisaki Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan

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Takahiro Fukuhara Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan

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Hiroya Kitano Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan
Center for Head and Neck Surgery, Kusatsu General Hospital, Kusatsu, Japan

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Hiromi Takeuchi Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan

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thyroid gland integrity may have resulted from treatment-related hypothyroidism, which was induced by the mechanisms mentioned above. Hypothyroidism was observed within 4 weeks after the initiation of lenvatinib, and therefore we should frequently examine

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