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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Roberto Attanasio Endocrine Unit, IRCCS Istituto Galeazzi, Milan, Italy

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Enrico Papini Department of Endocrinology and Metabolism, Ospedale Regina Apostolorum, Rome, Italy

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Kristian H. Winther Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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53 “sometimes” (39%), 41 “frequently” (30.1%), and 34 “always” (25%). Se supplementation was recommended by 83 ETA members (61%) as an alternative to surveillance alone in patients with mild ocular involvement and by 61 (44.9%) as a supplement to the

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Ian D Hay Department of Medicine 1, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Suneetha Kaggal Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Geoffrey B Thompson Department of Surgery, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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postoperative years, only 85/1318 (6%) of the BT-alone patients were being actively followed (remaining at risk), as were 89/541 (16%) of the BT+RRA patients, probably consistent with a greater intensity of postoperative tumor surveillance in those patients who

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Zoë Y.G.J. van Lierop Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands

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Sander Jentjens Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands

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Monique H.M.E. Anten Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands
Neurofibromatosis Expert Team, Maastricht University Medical Centre, Maastricht, The Netherlands

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Roel Wierts Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands

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Connie T. Stumpel Neurofibromatosis Expert Team, Maastricht University Medical Centre, Maastricht, The Netherlands
Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands

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Bas Havekes Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands

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Marinus J.P.G. van Kroonenburgh Neurofibromatosis Expert Team, Maastricht University Medical Centre, Maastricht, The Netherlands
Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands

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primary (autoimmune) thyroid disease, and the numbers lost to follow-up make our conclusions not firm but only indicative. Conclusions In the present form our study did not show an increased risk of thyroid pathology in NF1 patients. Active

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Roberto Negro Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy

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Roberto Attanasio Endocrinology Service, Galeazzi Institute IRCCS, Milan, Italy

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Enrico Papini Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Rinaldo Guglielmi Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Franco Grimaldi Endocrinology and Metabolic Disease Unit, Azienda Ospedaliero-Universitaria “S. Maria della Misericordia”, Udine, Italy

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Vincenzo Toscano Endocrinology, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Roma, Italy

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Dan Alexandru  Niculescu Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania

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Diana Loreta  Paun Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania

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Catalina Poiana Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania

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TSH. The active surveillance of TSH during pregnancy is justified by the evidence that about 20% of euthyroid women with TAI show TSH values > 4.0 mIU/L throughout gestation [ 27 , 28 ]. Whether or not LT4 treatment (suggested by about 20% of

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Signe Buhl Gram Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Jacob Høygaard Rasmussen Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Jens Bentzen Department of Oncology, Herlev Hospital, Copenhagen University, Copenhagen, Denmark

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Giedrius Lelkaitis Department of Pathology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Christian von Buchwald Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Christoffer Holst Hahn Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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thyroid microcarcinoma: time to shift from surgery to active surveillance? Lancet Diabetes Endocrinol . 2016 Nov ; 4 ( 11 ): 933 – 42 . 10.1016/S2213-8587(16)30180-2 27550849 2213-8587 13 Tee YY , Lowe AJ , Brand CA , Judson RT

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Stéphane Bardet Department of Nuclear Medicine and Thyroid Unit, Centre François Baclesse, Caen, France

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Renaud Ciappuccini Department of Nuclear Medicine and Thyroid Unit, Centre François Baclesse, Caen, France

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Livia Lamartina Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy, Villejuif, France

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy, Villejuif, France

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low tumour burden, active surveillance was advised. In June 2017, CT and CEA levels were 1097 ng/L and 9.5 µg/L, respectively, and MRI detected new small pelvic bone lesions, so treatment with denosumab was initiated. The symptoms were slowly but

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Camille Buffet Department of Thyroid Pathologies and Endocrine Tumors, AP-HP, Pitié-Salpêtrière Hospital, Groupe de Recherche Clinique n°16 Tumeurs Thyroïdiennes, Sorbonne Université, Paris, France
UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institut, Villejuif, France

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Françoise Kraeber-Bodéré Nuclear Medicine Department, Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA, Nantes, France
CHU Nantes/ICO, Saint-Herblain, France

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Caroline Bodet-Milin Nuclear Medicine Department, Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA, Nantes, France
CHU Nantes/ICO, Saint-Herblain, France

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Laure Cabanes Department of Cardiology, APHP, Cochin Hospital, Paris, France
Université de Paris, Paris, France

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Anthony Dohan Radiology Department, Université de Paris, Paris, France
Department of Radiology, AP-HP, Hôpital Cochin, Paris, France

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Pascal Leprince Department of Thoracic and Cardiovascular Surgery, Sorbonne Université, AP-HP, Pitié-Salpêtrière Hospital, Paris, France

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Martin Schlumberger UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institute, Villejuif, France

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Olivier Huillard Université de Paris, Sorbonne Paris Cité, Paris, France
Department of Medical Oncology, AP-HP, Hôpital Cochin, Paris, France

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Lionel Groussin INSERM Unité 1016, CNRS UMR 8104, Institut Cochin, Paris, France
Université de Paris, Paris, France
Department of Endocrinology, AP-HP, Hôpital Cochin, Paris, France

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active surveillance was chosen. Unfortunately, 1 year later, new hepatic and brain metastases (right 25-mm frontal-parietal and left occipital lesions of few millimeters) were diagnosed in the workup of myoclonic seizures of the left hand. This diagnosis

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Esther J. van Zuuren Departments of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands

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Amira Y. Albusta College of Medicine, AMA International University of Bahrain, Manama

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Zbys Fedorowicz UKCC (Bahrain Branch), The Cochrane Collaboration, Awali, Bahrain

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Ben Carter Institute of Primary Care & Public Health, Cardiff University School of Medicine, Cardiff, UK

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Hanno Pijl Departments of Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands

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thyroglobulin to produce thyroid hormone. The active form of thyroid hormone, tri-iodothyronine (T3), is produced by de-iodination of the prohormone T4 by type I and type II iodothyronine de-iodinasesin, a two-substrate ‘ping-pong' mechanism of reaction, along

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Kris Poppe Endocrine Unit, Department of Internal Medicine, University Hospital UZ Brussel (VUB), Brussels, Belgium

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Alicja Hubalewska-Dydejczyk Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland

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Peter Laurberg Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce

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Francesco Vermiglio Cattedra di Endocrinologia, Policlinico Universitario, Messina, Italy

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Bijay Vaidya Department of Endocrinology, Royal Devon & Exeter Hospital, Exeter, UK

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responders would never measure TRAb during the pregnancy compared to 11% in women with actively treated GD; p = 0.026 (table 4 ). Table 4 Responders’ recommendations for the measurement of TRAb during pregnancy in a woman with GD on ATDs and in a

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Roberto Fiore Division of Endocrinology, Diabetes and Metabolism, University Hospital of Lausanne and University of Lausanne, Hôtel des Patients, Lausanne, Switzerland

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Stefano La Rosa Unit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy

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Silvia Uccella Unit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy

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Deborah Marchiori Unit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy

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Peter A Kopp Division of Endocrinology, Diabetes and Metabolism, University Hospital of Lausanne and University of Lausanne, Hôtel des Patients, Lausanne, Switzerland

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thyroxine (T4). Deiodination of the outer ring generates the active thyroid hormone triiodothyronine (T3), whereas that of the inner ring converts T4 to reverse T3 (rT3), and T3 to 3,3’-diiodo- l -thyronine (T2), which are both biologically inactive

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